Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Foxa2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FOXA2
- Mouse genes Foxa2
- Rat genes Foxa2
- Zfish genes foxa2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxa2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Foxa2	IDA		Mouse	PMID:22780989
Molecular Function	GO:0003677	DNA binding	FOXA2	IDA		Human	PMID:9931457
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Foxa2	IDA		Mouse	PMID:22696295
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Foxa2	IDA		Rat	PMID:10024498\|RGD:1627570
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXA2	IDA		Human	PMID:12124776
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXA2	IDA		Human	PMID:12911579
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXA2	IDA		Human	PMID:9931457
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxa2	IDA		Mouse	PMID:12488434
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxa2	IDA		Mouse	PMID:11914369
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxa2	IDA		Mouse	PMID:22921202
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxa2	IDA		Rat	PMID:11562369\|RGD:70587
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxa2	IMP		Rat	PMID:17408383\|RGD:1626707
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Foxa2	IDA		Mouse	PMID:10859308
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Foxa2	IDA		Mouse	PMID:14701942
Molecular Function	GO:0003690	double-stranded DNA binding	Foxa2	IGI	MGI:MGI:1890508	Mouse	PMID:23117660
Molecular Function	GO:0003690	double-stranded DNA binding	Foxa2	IDA		Rat	PMID:10024498\|RGD:1627570
Molecular Function	GO:0003690	double-stranded DNA binding	Foxa2	IDA		Rat	PMID:17408383\|RGD:1626707
Molecular Function	GO:0019900	kinase binding	Foxa2	IPI	RGD:1319072	Rat	PMID:19478084\|RGD:5133270
Molecular Function	GO:0003676	nucleic acid binding	FOXA2	EXP		Human	PMID:28644006
Molecular Function	GO:0005515	protein binding	Foxa2	IPI	UniProtKB:Q61221	Mouse	MGI:MGI:4461337\|PMID:20609350
Molecular Function	GO:0005515	protein binding	Foxa2	IPI	UniProtKB:Q04724	Rat	PMID:10748198\|RGD:8553421
Molecular Function	GO:0005515	protein binding	Foxa2	IPI	UniProtKB:Q9JIT3	Rat	PMID:10748198\|RGD:8553421
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXA2	IDA		Human	PMID:12642491
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Foxa2	IDA		Mouse	PMID:16912278
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Foxa2	IDA		Mouse	PMID:12488434
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Foxa2	IDA		Mouse	PMID:15485926
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Foxa2	IDA		Mouse	PMID:15987774
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Foxa2	IDA		Rat	PMID:20735474\|RGD:8553707
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxa2	IDA		Mouse	PMID:14701942
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxa2	IDA		Mouse	PMID:22737085
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxa2	IDA		Mouse	PMID:11914369
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxa2	IDA		Rat	PMID:17408383\|RGD:1626707
Molecular Function	GO:0043565	sequence-specific DNA binding	foxa2	IDA		Zfish	PMID:18455719
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	FOXA2	IDA		Human	PMID:28473536
Molecular Function	GO:0046332	SMAD binding	Foxa2	IDA		Rat	PMID:18003659\|RGD:2314176
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXA2	IMP		Human	PMID:15737987
Molecular Function	GO:0000976	transcription cis-regulatory region binding	foxa2	IDA		Zfish	PMID:27222589
Cellular Component	GO:0030054	cell junction	FOXA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FOXA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FOXA2	IDA		Human	PMID:20160041
Cellular Component	GO:0005634	nucleus	FOXA2	IDA		Human	PMID:24399192
Cellular Component	GO:0005634	nucleus	FOXA2	IDA		Human	PMID:9931457
Cellular Component	GO:0005634	nucleus	Foxa2	IDA		Mouse	PMID:8813084
Cellular Component	GO:0005634	nucleus	Foxa2	IDA		Mouse	PMID:15567715
Cellular Component	GO:0005634	nucleus	Foxa2	IDA		Mouse	PMID:23383217
Cellular Component	GO:0005634	nucleus	Foxa2	IDA		Mouse	PMID:16364283
Cellular Component	GO:0005634	nucleus	Foxa2	IDA		Mouse	PMID:12488434
Cellular Component	GO:0005634	nucleus	Foxa2	IDA		Rat	PMID:10024498\|RGD:1627570
Cellular Component	GO:0005634	nucleus	Foxa2	IDA		Rat	PMID:11875061\|RGD:8553263
Cellular Component	GO:0005634	nucleus	Foxa2	IDA		Rat	PMID:17408383\|RGD:1626707
Cellular Component	GO:0005667	transcription regulator complex	Foxa2	IDA		Mouse	PMID:26494787
Biological Process	GO:0008344	adult locomotory behavior	Foxa2	IMP	MGI:MGI:1857725	Mouse	PMID:18076286
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:23383217
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Foxa2	IGI	MGI:MGI:99783	Mouse	PMID:10498685
Biological Process	GO:0009653	anatomical structure morphogenesis	Foxa2	IGI	MGI:MGI:95841	Mouse	PMID:9226455
Biological Process	GO:0009952	anterior/posterior pattern specification	Foxa2	IGI	MGI:MGI:99783	Mouse	PMID:10498685
Biological Process	GO:0048319	axial mesoderm morphogenesis	foxa2	IGI	ZFIN:ZDB-MRPHLNO-050228-2,ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2	Zfish	PMID:21172337
Biological Process	GO:0048319	axial mesoderm morphogenesis	foxa2	IGI	ZFIN:ZDB-MRPHLNO-050228-2,ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2,ZFIN:ZDB-MRPHLNO-110304-4	Zfish	PMID:21172337
Biological Process	GO:0048319	axial mesoderm morphogenesis	foxa2	IGI	ZFIN:ZDB-MRPHLNO-050228-2,ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2,ZFIN:ZDB-MRPHLNO-110304-3	Zfish	PMID:21172337
Biological Process	GO:0048468	cell development	Foxa2	IMP	MGI:MGI:2177337,MGI:MGI:2664968	Mouse	PMID:15680365
Biological Process	GO:0021533	cell differentiation in hindbrain	Foxa2	IMP	MGI:MGI:2176222,MGI:MGI:2177337	Mouse	PMID:17922007
Biological Process	GO:0021533	cell differentiation in hindbrain	Foxa2	IGI	MGI:MGI:1347476	Mouse	PMID:17922007
Biological Process	GO:0001708	cell fate specification	Foxa2	IDA		Mouse	PMID:18076286
Biological Process	GO:0071276	cellular response to cadmium ion	Foxa2	IDA		Mouse	PMID:15219627
Biological Process	GO:0032289	central nervous system myelin formation	foxa2	IMP	ZFIN:ZDB-GENO-050228-1	Zfish	PMID:16875686
Biological Process	GO:0061448	connective tissue development	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:23383217
Biological Process	GO:0006351	DNA-templated transcription	Foxa2	IDA		Mouse	MGI:MGI:3037232\|PMID:14701942
Biological Process	GO:0071542	dopaminergic neuron differentiation	FOXA2	IGI	UniProtKB:P32243,UniProtKB:Q9JKU8	Human	PMID:19951692
Biological Process	GO:0071542	dopaminergic neuron differentiation	Foxa2	IMP	MGI:MGI:1857725	Mouse	PMID:18076286
Biological Process	GO:0071542	dopaminergic neuron differentiation	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:17596284
Biological Process	GO:0071542	dopaminergic neuron differentiation	Foxa2	IMP	MGI:MGI:2177337	Mouse	PMID:17596284
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Foxa2	IDA		Mouse	PMID:18590716
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:23383217
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Foxa2	IGI	MGI:MGI:95841	Mouse	PMID:9226455
Biological Process	GO:0009953	dorsal/ventral pattern formation	Foxa2	IGI	MGI:MGI:99783	Mouse	PMID:10498685
Biological Process	GO:0001705	ectoderm formation	Foxa2	IGI	MGI:MGI:99783	Mouse	PMID:10498685
Biological Process	GO:0031018	endocrine pancreas development	FOXA2	IDA		Human	PMID:12124776
Biological Process	GO:0031018	endocrine pancreas development	Foxa2	IMP	MGI:MGI:2177337,MGI:MGI:2664968	Mouse	PMID:15680365
Biological Process	GO:0007492	endoderm development	foxa2	IGI	ZFIN:ZDB-GENO-080819-6,ZFIN:ZDB-MRPHLNO-050228-2	Zfish	PMID:18394596
Biological Process	GO:0007492	endoderm development	foxa2	IMP	ZFIN:ZDB-MRPHLNO-050228-2	Zfish	PMID:18394596
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:15668254
Biological Process	GO:0033504	floor plate development	foxa2	IMP	ZFIN:ZDB-MRPHLNO-050228-2	Zfish	PMID:12453456
Biological Process	GO:0033504	floor plate development	foxa2	IMP	ZFIN:ZDB-MRPHLNO-050228-2	Zfish	PMID:21172337
Biological Process	GO:0010467	gene expression	Foxa2	IMP		Mouse	PMID:29659575
Biological Process	GO:0010255	glucose mediated signaling pathway	Foxa2	IDA		Mouse	MGI:MGI:5142372\|PMID:11875061
Biological Process	GO:0001701	in utero embryonic development	Foxa2	IMP		Mouse	PMID:9152011
Biological Process	GO:0030324	lung development	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:15668254
Biological Process	GO:0060487	lung epithelial cell differentiation	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:15668254
Biological Process	GO:0048382	mesendoderm development	Foxa2	IMP	MGI:MGI:5698524,MGI:MGI:2656539	Mouse	PMID:26494787
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	FOXA2	IMP		Human	PMID:12642491
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	FOXA2	IMP		Human	PMID:20160041
Biological Process	GO:0033132	negative regulation of glucokinase activity	Foxa2	IDA		Mouse	MGI:MGI:5142372\|PMID:11875061
Biological Process	GO:0045665	negative regulation of neuron differentiation	Foxa2	IGI	MGI:MGI:1347476	Mouse	PMID:17922007
Biological Process	GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	Foxa2	IDA		Mouse	MGI:MGI:5142372\|PMID:11875061
Biological Process	GO:0030182	neuron differentiation	Foxa2	IGI	MGI:MGI:1347476	Mouse	PMID:17922007
Biological Process	GO:0030182	neuron differentiation	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:17596284
Biological Process	GO:0030182	neuron differentiation	Foxa2	IMP	MGI:MGI:2176222,MGI:MGI:2177337	Mouse	PMID:17922007
Biological Process	GO:0030182	neuron differentiation	Foxa2	IMP	MGI:MGI:2177337	Mouse	PMID:17596284
Biological Process	GO:0048665	neuron fate specification	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:17596284
Biological Process	GO:0048665	neuron fate specification	Foxa2	IMP	MGI:MGI:2176222,MGI:MGI:2177337	Mouse	PMID:17922007
Biological Process	GO:0007219	Notch signaling pathway	Foxa2	IDA		Mouse	PMID:25446530
Biological Process	GO:0021779	oligodendrocyte cell fate commitment	foxa2	IMP	ZFIN:ZDB-GENO-050228-1	Zfish	PMID:16875686
Biological Process	GO:0007389	pattern specification process	Foxa2	IGI	MGI:MGI:95664	Mouse	PMID:10498685
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FOXA2	IDA		Human	PMID:9931457
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Foxa2	IMP		Mouse	MGI:MGI:2157654\|PMID:11291865
Biological Process	GO:1904340	positive regulation of dopaminergic neuron differentiation	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:17596284
Biological Process	GO:1904340	positive regulation of dopaminergic neuron differentiation	Foxa2	IMP	MGI:MGI:2177337	Mouse	PMID:17596284
Biological Process	GO:0040019	positive regulation of embryonic development	Foxa2	IMP		Mouse	MGI:MGI:2157654\|PMID:11291865
Biological Process	GO:2000543	positive regulation of gastrulation	Foxa2	IMP		Mouse	MGI:MGI:2157654\|PMID:11291865
Biological Process	GO:0045666	positive regulation of neuron differentiation	Foxa2	IGI	MGI:MGI:1347476	Mouse	PMID:17922007
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:23383217
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXA2	IDA		Human	PMID:12124776
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXA2	IDA		Human	PMID:20160041
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa2	IDA		Mouse	PMID:10859308
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa2	IMP		Mouse	PMID:9152011
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa2	IDA		Mouse	PMID:11914369
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa2	IDA		Mouse	PMID:22696295
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa2	IGI	MGI:MGI:95664	Mouse	PMID:15539431
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa2	IDA		Rat	PMID:10024498\|RGD:1627570
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa2	IMP		Rat	PMID:17408383\|RGD:1626707
Biological Process	GO:0045945	positive regulation of transcription by RNA polymerase III	Foxa2	IMP		Mouse	MGI:MGI:4456945\|PMID:15737987
Biological Process	GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	Foxa2	IDA		Mouse	MGI:MGI:5142372\|PMID:11875061
Biological Process	GO:0090009	primitive streak formation	Foxa2	IMP	MGI:MGI:1857725	Mouse	PMID:11291865
Biological Process	GO:0030193	regulation of blood coagulation	FOXA2	IDA		Human	PMID:12911579
Biological Process	GO:0006355	regulation of DNA-templated transcription	Foxa2	IDA		Mouse	PMID:12488434
Biological Process	GO:0006355	regulation of DNA-templated transcription	Foxa2	IDA		Rat	PMID:11562369\|RGD:70587
Biological Process	GO:0010468	regulation of gene expression	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:17596284
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Foxa2	IDA		Mouse	MGI:MGI:5142372\|PMID:11875061
Biological Process	GO:0019216	regulation of lipid metabolic process	Foxa2	IDA		Mouse	PMID:22737085
Biological Process	GO:0019216	regulation of lipid metabolic process	Foxa2	IMP		Mouse	PMID:22737085
Biological Process	GO:0019218	regulation of steroid metabolic process	Foxa2	IDA		Mouse	PMID:22737085
Biological Process	GO:0019218	regulation of steroid metabolic process	Foxa2	IMP		Mouse	PMID:22737085
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	FOXA2	IDA		Human	PMID:12911579
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Foxa2	IDA		Mouse	MGI:MGI:3037232\|PMID:14701942
Biological Process	GO:0032868	response to insulin	Foxa2	IEP		Rat	PMID:19433262\|RGD:2312358
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Foxa2	IDA		Mouse	PMID:18462699
Biological Process	GO:0007224	smoothened signaling pathway	Foxa2	IGI	MGI:MGI:1347472	Mouse	PMID:23383217
Biological Process	GO:0032525	somite rostral/caudal axis specification	Foxa2	IMP	MGI:MGI:1857725	Mouse	PMID:11291865
Biological Process	GO:0006366	transcription by RNA polymerase II	Foxa2	IDA		Mouse	PMID:10859308
Biological Process	GO:0007418	ventral midline development	foxa2	IMP	ZFIN:ZDB-GENO-980202-973	Zfish	PMID:15677724

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.