Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FOXA3
  • Mouse genes Foxa3
  • Rat genes Foxa3
  • Zfish genes foxa3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxa3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Foxa3	IDA		Mouse	PMID:7683413
Molecular Function	GO:0003677	DNA binding	Foxa3	IDA		Rat	PMID:12000309|RGD:625455
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXA3	IDA		Human	PMID:12695546
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxa3	IDA		Rat	PMID:12000309|RGD:625455
Molecular Function	GO:0005515	protein binding	FOXA3	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FOXA3	IPI	UniProtKB:P28329-3	Human	PMID:32814053
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxa3	IDA		Mouse	PMID:8306889
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	FOXA3	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXA3	IMP		Human	PMID:12695546
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXA3	IMP		Human	PMID:18239190
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXA3	IMP		Human	PMID:9369482
Cellular Component	GO:0015629	actin cytoskeleton	FOXA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FOXA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Foxa3	IDA		Mouse	PMID:8306889
Cellular Component	GO:0005634	nucleus	Foxa3	IDA		Rat	PMID:12000309|RGD:625455
Cellular Component	GO:0005634	nucleus	foxa3	IDA		Zfish	PMID:9895329
Biological Process	GO:0048319	axial mesoderm morphogenesis	foxa3	IGI	ZFIN:ZDB-MRPHLNO-050228-2,ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2,ZFIN:ZDB-MRPHLNO-110304-4	Zfish	PMID:21172337
Biological Process	GO:0048319	axial mesoderm morphogenesis	foxa3	IMP	ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2	Zfish	PMID:21172337
Biological Process	GO:0048319	axial mesoderm morphogenesis	foxa3	IGI	ZFIN:ZDB-MRPHLNO-050228-2,ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2,ZFIN:ZDB-MRPHLNO-110304-3	Zfish	PMID:21172337
Biological Process	GO:0048319	axial mesoderm morphogenesis	foxa3	IGI	ZFIN:ZDB-MRPHLNO-050228-2,ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2	Zfish	PMID:21172337
Biological Process	GO:0007420	brain development	foxa3	IGI	ZFIN:ZDB-MRPHLNO-060321-1,ZFIN:ZDB-MRPHLNO-060321-4	Zfish	PMID:16364286
Biological Process	GO:0009267	cellular response to starvation	Foxa3	IMP	MGI:MGI:2178218	Mouse	PMID:11546810
Biological Process	GO:0033504	floor plate development	foxa3	IMP	ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2	Zfish	PMID:21172337
Biological Process	GO:0048785	hatching gland development	foxa3	IMP	ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2	Zfish	PMID:21172337
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Foxa3	IMP		Mouse	PMID:26880577
Biological Process	GO:0001678	intracellular glucose homeostasis	Foxa3	IMP	MGI:MGI:2178218	Mouse	PMID:11546810
Biological Process	GO:0008285	negative regulation of cell population proliferation	Foxa3	IMP		Rat	PMID:9878541|RGD:2315086
Biological Process	GO:0021999	neural plate anterior/posterior regionalization	foxa3	IGI	ZFIN:ZDB-MRPHLNO-060321-1,ZFIN:ZDB-MRPHLNO-060321-4	Zfish	PMID:16364286
Biological Process	GO:0070368	positive regulation of hepatocyte differentiation	Foxa3	IMP		Rat	PMID:9878541|RGD:2315086
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXA3	IDA		Human	PMID:12695546
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa3	IGI	MGI:MGI:1353422	Mouse	PMID:19759516
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa3	IDA		Rat	PMID:9369482|RGD:8553889
Biological Process	GO:0006355	regulation of DNA-templated transcription	Foxa3	IMP	MGI:MGI:2178218	Mouse	PMID:11546810
Biological Process	GO:0006355	regulation of DNA-templated transcription	Foxa3	IDA		Rat	PMID:12000309|RGD:625455
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Foxa3	IMP		Mouse	MGI:MGI:3785678|PMID:17488644
Biological Process	GO:0031667	response to nutrient levels	Foxa3	IEP		Rat	PMID:11018767|RGD:2315085
Biological Process	GO:0007283	spermatogenesis	Foxa3	IMP		Mouse	MGI:MGI:3785678|PMID:17488644
Biological Process	GO:0006366	transcription by RNA polymerase II	Foxa3	IGI	MGI:MGI:1353422	Mouse	PMID:19759516

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern