Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FOXC2
  • Mouse genes Foxc2
  • Rat genes Foxc2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	FOXC2	IDA		Human	PMID:16456100
Molecular Function	GO:0003677	DNA binding	Foxc2	IDA		Mouse	PMID:8325367
Molecular Function	GO:0003677	DNA binding	Foxc2	IDA		Rat	PMID:7683413|RGD:632667
Molecular Function	GO:0001216	DNA-binding transcription activator activity	FOXC2	IDA		Human	PMID:9169153
Molecular Function	GO:0001216	DNA-binding transcription activator activity	Foxc2	IDA		Mouse	MGI:MGI:87500|PMID:9169153
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXC2	IDA		Human	PMID:20956529
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxc2	IMP		Mouse	MGI:MGI:3773495|PMID:18187037
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxc2	IDA		Mouse	MGI:MGI:3813419|PMID:18579532
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16678147
Molecular Function	GO:0042802	identical protein binding	FOXC2	IPI	UniProtKB:Q99958	Human	PMID:25609649
Molecular Function	GO:1990841	promoter-specific chromatin binding	Foxc2	IDA		Mouse	MGI:MGI:3773495|PMID:18187037
Molecular Function	GO:0005515	protein binding	FOXC2	IPI	UniProtKB:P14373	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXC2	IPI	UniProtKB:Q86VP1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXC2	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXC2	IPI	UniProtKB:Q96IQ6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXC2	IPI	UniProtKB:Q08379	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FOXC2	IPI	UniProtKB:Q8N6F8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FOXC2	IPI	UniProtKB:Q9BYR6	Human	PMID:32296183
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXC2	IDA		Human	PMID:20956529
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXC2	IDA		Human	PMID:20956529
Molecular Function	GO:0043565	sequence-specific DNA binding	FOXC2	IDA		Human	PMID:16081467
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	FOXC2	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Foxc2	IDA		Mouse	MGI:MGI:3813419|PMID:18579532
Cellular Component	GO:0016604	nuclear body	FOXC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FOXC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FOXC2	IDA		Human	PMID:11562355
Cellular Component	GO:0005634	nucleus	FOXC2	IDA		Human	PMID:16081467
Biological Process	GO:0003275	apoptotic process involved in outflow tract morphogenesis	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16839542
Biological Process	GO:0048844	artery morphogenesis	Foxc2	IMP	MGI:MGI:1857740	Mouse	PMID:9409679
Biological Process	GO:0048844	artery morphogenesis	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:10479458
Biological Process	GO:0001568	blood vessel development	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16678147
Biological Process	GO:0097746	blood vessel diameter maintenance	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16678147
Biological Process	GO:0001974	blood vessel remodeling	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16678147
Biological Process	GO:0001974	blood vessel remodeling	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:11562355
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Foxc2	IGI	MGI:MGI:105923	Mouse	PMID:15664398
Biological Process	GO:0043010	camera-type eye development	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:10767326
Biological Process	GO:0060038	cardiac muscle cell proliferation	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16839542
Biological Process	GO:0008283	cell population proliferation	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:9106663
Biological Process	GO:0008283	cell population proliferation	Foxc2	IMP	MGI:MGI:1857740	Mouse	PMID:10364424
Biological Process	GO:0030199	collagen fibril organization	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:10767326
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:9106663
Biological Process	GO:0035050	embryonic heart tube development	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16678147
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Foxc2	IMP	MGI:MGI:1857740	Mouse	PMID:9409679
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	Foxc2	IMP	MGI:MGI:1857740	Mouse	PMID:9409679
Biological Process	GO:0072011	glomerular endothelium development	Foxc2	IMP	MGI:MGI:1857740	Mouse	PMID:16498405
Biological Process	GO:0072144	glomerular mesangial cell development	Foxc2	IMP	MGI:MGI:1857740	Mouse	PMID:16498405
Biological Process	GO:0007507	heart development	FOXC2	IMP		Human	PMID:21457232
Biological Process	GO:0007507	heart development	Foxc2	IGI	MGI:MGI:105923	Mouse	PMID:15664398
Biological Process	GO:0007507	heart development	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16839542
Biological Process	GO:0007507	heart development	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:10479458
Biological Process	GO:0003007	heart morphogenesis	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16839542
Biological Process	GO:0008286	insulin receptor signaling pathway	FOXC2	IDA		Human	PMID:16456100
Biological Process	GO:0001822	kidney development	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:10704385
Biological Process	GO:0001945	lymph vessel development	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16678147
Biological Process	GO:0001946	lymphangiogenesis	FOXC2	IMP		Human	PMID:12114478
Biological Process	GO:0001656	metanephros development	Foxc2	IMP	MGI:MGI:1857740	Mouse	PMID:16498405
Biological Process	GO:1902257	negative regulation of apoptotic process involved in outflow tract morphogenesis	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16839542
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	FOXC2	IMP		Human	PMID:11551504
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Foxc2	IDA		Mouse	MGI:MGI:3813419|PMID:18579532
Biological Process	GO:0014032	neural crest cell development	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16839542
Biological Process	GO:0007219	Notch signaling pathway	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:11562355
Biological Process	GO:0001503	ossification	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:9106663
Biological Process	GO:0048341	paraxial mesoderm formation	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:11562355
Biological Process	GO:0048343	paraxial mesodermal cell fate commitment	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:9106663
Biological Process	GO:0072112	podocyte differentiation	Foxc2	IMP	MGI:MGI:1857740	Mouse	PMID:16498405
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	Foxc2	IDA		Mouse	MGI:MGI:3813419|PMID:18579532
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	Foxc2	IDA		Mouse	MGI:MGI:3813419|PMID:18579532
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FOXC2	IDA		Human	PMID:16081467
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FOXC2	IDA		Human	PMID:9169153
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Foxc2	IDA		Mouse	MGI:MGI:87500|PMID:9169153
Biological Process	GO:0010595	positive regulation of endothelial cell migration	Foxc2	IDA		Mouse	MGI:MGI:3813419|PMID:18579532
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXC2	IDA		Human	PMID:20956529
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxc2	IDA		Mouse	MGI:MGI:3813419|PMID:18579532
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxc2	IMP		Mouse	MGI:MGI:3773495|PMID:18187037
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxc2	IDA		Mouse	PMID:16678147
Biological Process	GO:0035470	positive regulation of vascular wound healing	Foxc2	IDA		Mouse	MGI:MGI:3813419|PMID:18579532
Biological Process	GO:0046620	regulation of organ growth	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16839542
Biological Process	GO:0009725	response to hormone	FOXC2	IDA		Human	PMID:16456100
Biological Process	GO:0001501	skeletal system development	Foxc2	IMP	MGI:MGI:1857740	Mouse	PMID:10364424
Biological Process	GO:0001501	skeletal system development	Foxc2	IGI	MGI:MGI:97485	Mouse	PMID:10364424
Biological Process	GO:0001756	somitogenesis	Foxc2	IGI	UniProtKB:Q61572	Mouse	MGI:MGI:2150572|PMID:11562355
Biological Process	GO:0001657	ureteric bud development	Foxc2	IMP	MGI:MGI:1857865	Mouse	PMID:10704385
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16678147
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	Foxc2	IGI	MGI:MGI:1347466	Mouse	PMID:16839542

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern