Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FOXK1
  • Mouse genes Foxk1
  • Rat genes Foxk1
  • Zfish genes foxk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	FOXK1	IPI	UniProtKB:P62259	Human	PMID:29861159
Molecular Function	GO:0003677	DNA binding	Foxk1	IDA		Mouse	MGI:MGI:3687784|PMID:10620510
Molecular Function	GO:0003677	DNA binding	Foxk1	IDA		Mouse	PMID:9271401
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXK1	IDA		Human	PMID:29861159
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXK1	IDA		Human	PMID:30700909
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Foxk1	IDA		Mouse	MGI:MGI:1096643|PMID:9271401
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	FOXK1	IDA		Human	PMID:17670796
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	FOXK1	IDA		Human	PMID:25402684
Molecular Function	GO:0005515	protein binding	FOXK1	IPI	UniProtKB:P11831	Human	PMID:17670796
Molecular Function	GO:0005515	protein binding	FOXK1	IPI	UniProtKB:P14316	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	FOXK1	IPI	UniProtKB:Q60520	Human	PMID:25402684
Molecular Function	GO:0005515	protein binding	FOXK1	IPI	UniProtKB:Q92560	Human	PMID:25451922
Molecular Function	GO:0005515	protein binding	FOXK1	IPI	UniProtKB:O43524	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	FOXK1	IPI	UniProtKB:P14316	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Foxk1	IPI	UniProtKB:Q62141-2	Mouse	MGI:MGI:3687784|PMID:10620510
Molecular Function	GO:0005515	protein binding	Foxk1	IPI	UniProtKB:Q62141-2	Mouse	MGI:MGI:5487501|PMID:22476904
Molecular Function	GO:0005515	protein binding	Foxk1	IPI	UniProtKB:Q62141-2|UniProtKB:Q62141-2	Mouse	MGI:MGI:3687784|PMID:10620510
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Foxk1	IDA		Mouse	MGI:MGI:1096643|PMID:9271401
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxk1	IDA		Mouse	MGI:MGI:67110|PMID:8007964
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxk1	IDA		Mouse	MGI:MGI:1096643|PMID:9271401
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	FOXK1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXK1	IDA		Human	PMID:17670796
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXK1	IDA		Human	PMID:25402684
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXK1	IDA		Human	PMID:29861159
Cellular Component	GO:0005737	cytoplasm	FOXK1	IDA		Human	PMID:25402684
Cellular Component	GO:0005737	cytoplasm	FOXK1	IDA		Human	PMID:29861159
Cellular Component	GO:0005634	nucleus	FOXK1	IDA		Human	PMID:25402684
Cellular Component	GO:0005634	nucleus	FOXK1	IDA		Human	PMID:29861159
Biological Process	GO:0061621	canonical glycolysis	FOXK1	IDA		Human	PMID:30700909
Biological Process	GO:0001678	intracellular glucose homeostasis	FOXK1	IDA		Human	PMID:29861159
Biological Process	GO:0001678	intracellular glucose homeostasis	FOXK1	IDA		Human	PMID:30700909
Biological Process	GO:0010507	negative regulation of autophagy	FOXK1	IDA		Human	PMID:25402684
Biological Process	GO:0030308	negative regulation of cell growth	Foxk1	IDA		Mouse	MGI:MGI:3687784|PMID:10620510
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	FOXK1	IDA		Human	PMID:17670796
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	FOXK1	IDA		Human	PMID:25402684
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Foxk1	IDA		Mouse	MGI:MGI:1096643|PMID:9271401
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Foxk1	IDA		Mouse	MGI:MGI:3687784|PMID:10620510
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FOXK1	IDA		Human	PMID:29861159
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FOXK1	IDA		Human	PMID:30700909
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Foxk1	IDA		Mouse	MGI:MGI:67110|PMID:8007964
Biological Process	GO:0010906	regulation of glucose metabolic process	FOXK1	IDA		Human	PMID:29861159
Biological Process	GO:0010906	regulation of glucose metabolic process	FOXK1	IDA		Human	PMID:30700909
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Foxk1	IDA		Mouse	PMID:9271401
Biological Process	GO:0042594	response to starvation	FOXK1	IDA		Human	PMID:25402684

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern