Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FOXL2
  • Mouse genes Foxl2
  • Rat genes Foxl2
  • Zfish genes foxl2a,foxl2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	FOXL2	IMP		Human	PMID:16153597
Molecular Function	GO:0003677	DNA binding	FOXL2	IDA		Human	PMID:16720712
Molecular Function	GO:0003677	DNA binding	Foxl2	IDA		Mouse	PMID:12943993
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Foxl2	IDA		Mouse	MGI:MGI:2675699|PMID:12943993
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxl2	IDA		Mouse	PMID:12943993
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Foxl2	IPI	UniProtKB:P19785	Mouse	MGI:MGI:4430655|PMID:19797124
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Foxl2	IPI	UniProtKB:P19785	Mouse	MGI:MGI:4429740|PMID:20005806
Molecular Function	GO:0005515	protein binding	FOXL2	IPI	UniProtKB:Q9JIK3	Human	PMID:16153597
Molecular Function	GO:0005515	protein binding	FOXL2	IPI	UniProtKB:Q9JJY4	Human	PMID:16153597
Molecular Function	GO:0005515	protein binding	Foxl2	IPI	PR:Q9JJY4	Mouse	PMID:16153597
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Foxl2	IDA		Mouse	MGI:MGI:2675699|PMID:12943993
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	FOXL2	IDA		Human	PMID:28473536
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	FOXL2	IPI	UniProtKB:P63279	Human	PMID:19744555
Cellular Component	GO:0090543	Flemming body	FOXL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FOXL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FOXL2	IDA		Human	PMID:12471206
Cellular Component	GO:0005634	nucleus	Foxl2	IDA		Mouse	MGI:MGI:4430655|PMID:19797124
Cellular Component	GO:0005634	nucleus	Foxl2	IDA		Mouse	PMID:21991325
Cellular Component	GO:0005634	nucleus	Foxl2	IDA		Mouse	PMID:15056605
Biological Process	GO:0006309	apoptotic DNA fragmentation	FOXL2	IMP		Human	PMID:16153597
Biological Process	GO:0048048	embryonic eye morphogenesis	Foxl2	IMP	MGI:MGI:3044226	Mouse	PMID:15056605
Biological Process	GO:0002074	extraocular skeletal muscle development	FOXL2	IMP		Human	PMID:12630957
Biological Process	GO:0008585	female gonad development	Foxl2	IGI	MGI:MGI:894293	Mouse	PMID:24739304
Biological Process	GO:0019101	female somatic sex determination	Foxl2	IMP	MGI:MGI:2182312	Mouse	PMID:15944199
Biological Process	GO:0060014	granulosa cell differentiation	Foxl2	IMP	MGI:MGI:3029503	Mouse	PMID:14736745
Biological Process	GO:0048496	maintenance of animal organ identity	foxl2a	IGI	ZFIN:ZDB-GENO-170814-2	Zfish	PMID:28193729
Biological Process	GO:0048496	maintenance of animal organ identity	foxl2a	IMP	ZFIN:ZDB-GENO-170811-1	Zfish	PMID:28193729
Biological Process	GO:0048496	maintenance of animal organ identity	foxl2b	IMP	ZFIN:ZDB-GENO-170811-2	Zfish	PMID:28193729
Biological Process	GO:0048496	maintenance of animal organ identity	foxl2b	IGI	ZFIN:ZDB-GENO-170814-2	Zfish	PMID:28193729
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	FOXL2	IDA		Human	PMID:19744555
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Foxl2	IMP	MGI:MGI:3044226	Mouse	PMID:21757499
Biological Process	GO:0010629	negative regulation of gene expression	Foxl2	IMP		Rat	PMID:23567549|RGD:151893499
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Foxl2	IMP	MGI:MGI:3044226	Mouse	PMID:21757499
Biological Process	GO:0001541	ovarian follicle development	FOXL2	IMP		Human	PMID:12161610
Biological Process	GO:0001541	ovarian follicle development	Foxl2	IMP	MGI:MGI:3044226	Mouse	PMID:15056605
Biological Process	GO:0001541	ovarian follicle development	Foxl2	IGI	MGI:MGI:894293	Mouse	PMID:24739304
Biological Process	GO:0001541	ovarian follicle development	Foxl2	IMP	MGI:MGI:3029503	Mouse	PMID:14736745
Biological Process	GO:0043065	positive regulation of apoptotic process	FOXL2	IGI	UniProtKB:Q9UHI6	Human	PMID:16153597
Biological Process	GO:0043065	positive regulation of apoptotic process	FOXL2	IMP		Human	PMID:16153597
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	FOXL2	IMP		Human	PMID:16153597
Biological Process	GO:0046881	positive regulation of follicle-stimulating hormone secretion	Foxl2	IGI	MGI:MGI:894293	Mouse	PMID:24739304
Biological Process	GO:0033686	positive regulation of luteinizing hormone secretion	Foxl2	IGI	MGI:MGI:894293	Mouse	PMID:24739304
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxl2	IGI	MGI:MGI:894293	Mouse	PMID:24739304
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxl2	IDA		Mouse	PMID:12943993
Biological Process	GO:0044752	response to human chorionic gonadotropin	Foxl2	IEP		Rat	PMID:23239112|RGD:9831388
Biological Process	GO:0014070	response to organic cyclic compound	Foxl2	IEP		Rat	PMID:22777679|RGD:151893504
Biological Process	GO:0014070	response to organic cyclic compound	Foxl2	IEP		Rat	PMID:28208728|RGD:151893505
Biological Process	GO:0014070	response to organic cyclic compound	Foxl2	IEP		Rat	PMID:30599193|RGD:151893501
Biological Process	GO:0007338	single fertilization	Foxl2	IGI	MGI:MGI:894293	Mouse	PMID:24739304
Biological Process	GO:0060065	uterus development	Foxl2	IGI	MGI:MGI:894293	Mouse	PMID:24739304

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern