Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FOXN4
  • Mouse genes Foxn4
  • Rat genes Foxn4
  • Zfish genes foxn4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxn4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Foxn4	IDA		Mouse	MGI:MGI:5314555|PMID:22323600
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	FOXN4	IDA		Human	PMID:22323600
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Foxn4	IDA		Mouse	MGI:MGI:5314555|PMID:22323600
Molecular Function	GO:0003700	DNA-binding transcription factor activity	foxn4	IDA		Zfish	PMID:18347092
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Foxn4	IDA		Mouse	MGI:MGI:5546314|PMID:23652001
Molecular Function	GO:0005515	protein binding	FOXN4	IPI	UniProtKB:Q13643	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	FOXN4	IPI	UniProtKB:Q5VTB9	Human	PMID:30177510
Molecular Function	GO:0005515	protein binding	FOXN4	IPI	UniProtKB:P48378	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FOXN4	IPI	UniProtKB:P54253	Human	PMID:32296183
Molecular Function	GO:0043565	sequence-specific DNA binding	foxn4	IDA		Zfish	PMID:18347092
Cellular Component	GO:0005634	nucleus	Foxn4	IDA		Mouse	MGI:MGI:5314555|PMID:22323600
Biological Process	GO:0035881	amacrine cell differentiation	Foxn4	IMP	MGI:MGI:3054789	Mouse	PMID:15363391
Biological Process	GO:0036302	atrioventricular canal development	foxn4	IMP		Zfish	PMID:18347092|ZFIN:ZDB-PUB-080326-29
Biological Process	GO:0036302	atrioventricular canal development	foxn4	IGI	ZFIN:ZDB-GENO-161014-11,ZFIN:ZDB-MRPHLNO-161005-3	Zfish	PMID:27343557
Biological Process	GO:0001947	heart looping	foxn4	IMP		Zfish	PMID:18347092|ZFIN:ZDB-PUB-080326-29
Biological Process	GO:0003170	heart valve development	foxn4	IMP	ZFIN:ZDB-MRPHLNO-161005-3	Zfish	PMID:27343557
Biological Process	GO:0048663	neuron fate commitment	Foxn4	IGI	MGI:MGI:96919	Mouse	PMID:16020526
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	foxn4	IDA		Zfish	PMID:18347092
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxn4	IDA		Mouse	MGI:MGI:5546314|PMID:23652001
Biological Process	GO:0006355	regulation of DNA-templated transcription	Foxn4	IDA		Mouse	MGI:MGI:5314555|PMID:22323600
Biological Process	GO:0008016	regulation of heart contraction	foxn4	IMP		Zfish	PMID:18347092|ZFIN:ZDB-PUB-080326-29
Biological Process	GO:0008016	regulation of heart contraction	foxn4	IMP	ZFIN:ZDB-GENO-980202-1553	Zfish	PMID:9007249
Biological Process	GO:0010842	retina layer formation	Foxn4	IMP		Mouse	MGI:MGI:3054139|PMID:15363391
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	Foxn4	IMP		Mouse	MGI:MGI:4834949|PMID:20844123
Biological Process	GO:0060579	ventral spinal cord interneuron fate commitment	Foxn4	IMP		Mouse	MGI:MGI:3765356|PMID:17728344
Biological Process	GO:0060579	ventral spinal cord interneuron fate commitment	Foxn4	IMP		Mouse	MGI:MGI:3587461|PMID:16020526

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern