Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FOXO4
  • Mouse genes Foxo4
  • Rat genes Foxo4
  • Zfish genes foxo4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxo4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	FOXO4	IDA		Human	PMID:15905404
Molecular Function	GO:0003677	DNA binding	FOXO4	IDA		Human	PMID:10783894
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXO4	IDA		Human	PMID:11689711
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXO4	IDA		Human	PMID:10783894
Molecular Function	GO:0140297	DNA-binding transcription factor binding	FOXO4	IPI	UniProtKB:P11831	Human	PMID:16054032
Molecular Function	GO:0140297	DNA-binding transcription factor binding	FOXO4	IPI	UniProtKB:Q8IZQ8	Human	PMID:16054032
Molecular Function	GO:0019899	enzyme binding	FOXO4	IPI	UniProtKB:Q8IXJ6	Human	PMID:15126506
Molecular Function	GO:0019899	enzyme binding	FOXO4	IPI	UniProtKB:Q93009	Human	PMID:16964248
Molecular Function	GO:0042802	identical protein binding	FOXO4	IPI	UniProtKB:P98177	Human	PMID:25609649
Molecular Function	GO:0003676	nucleic acid binding	FOXO4	EXP		Human	PMID:11352721
Molecular Function	GO:1990841	promoter-specific chromatin binding	Foxo4	IDA		Rat	PMID:16054032|RGD:10402362
Molecular Function	GO:0005515	protein binding	FOXO4	IPI	UniProtKB:Q13485	Human	PMID:15084259
Molecular Function	GO:0005515	protein binding	FOXO4	IPI	UniProtKB:Q96EB6	Human	PMID:15126506
Molecular Function	GO:0005515	protein binding	FOXO4	IPI	UniProtKB:P63104	Human	PMID:16114898
Molecular Function	GO:0005515	protein binding	FOXO4	IPI	UniProtKB:P31947	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXO4	IPI	UniProtKB:Q04864	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Foxo4	IPI	UniProtKB:P56558	Mouse	MGI:MGI:5508575|PMID:19932102
Molecular Function	GO:0005515	protein binding	Foxo4	IPI	RGD:631347	Rat	PMID:16054032|RGD:10402362
Molecular Function	GO:0043565	sequence-specific DNA binding	FOXO4	IMP		Human	PMID:22972301
Molecular Function	GO:0043565	sequence-specific DNA binding	FOXO4	IDA		Human	PMID:23332764
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxo4	IDA		Mouse	PMID:11353388
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	FOXO4	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	FOXO4	IDA		Human	PMID:16964248
Cellular Component	GO:0005737	cytoplasm	Foxo4	IDA		Rat	PMID:23079979|RGD:10402359
Cellular Component	GO:0005829	cytosol	FOXO4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	FOXO4	IDA		Human	PMID:16272144
Cellular Component	GO:0005829	cytosol	Foxo4	IDA		Rat	PMID:17916612|RGD:2302520
Cellular Component	GO:0016607	nuclear speck	FOXO4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FOXO4	IDA		Human	PMID:16272144
Cellular Component	GO:0005634	nucleus	FOXO4	IDA		Human	PMID:16964248
Cellular Component	GO:0005634	nucleus	Foxo4	IDA		Rat	PMID:17916612|RGD:2302520
Cellular Component	GO:0005634	nucleus	Foxo4	IDA		Rat	PMID:21887848|RGD:10402358
Biological Process	GO:0007568	aging	Foxo4	IEP		Rat	PMID:12424797|RGD:10402357
Biological Process	GO:0008286	insulin receptor signaling pathway	FOXO4	IDA		Human	PMID:10217147
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	Foxo4	IDA		Mouse	PMID:12048180
Biological Process	GO:0016525	negative regulation of angiogenesis	FOXO4	IDA		Human	PMID:12761217
Biological Process	GO:0008285	negative regulation of cell population proliferation	FOXO4	IDA		Human	PMID:10783894
Biological Process	GO:0008285	negative regulation of cell population proliferation	Foxo4	IDA		Mouse	PMID:12048180
Biological Process	GO:0070317	negative regulation of G0 to G1 transition	FOXO4	IDA		Human	PMID:10783894
Biological Process	GO:0051151	negative regulation of smooth muscle cell differentiation	FOXO4	IDA		Human	PMID:16054032
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Foxo4	IDA		Mouse	PMID:14966295
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Foxo4	IDA		Mouse	PMID:12048180
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Foxo4	IMP		Rat	PMID:17242183|RGD:10402361
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXO4	IDA		Human	PMID:11689711
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXO4	IDA		Human	PMID:15905404
Biological Process	GO:0006355	regulation of DNA-templated transcription	FOXO4	IDA		Human	PMID:15126506
Biological Process	GO:0031667	response to nutrient levels	Foxo4	IEP		Rat	PMID:12424797|RGD:10402357
Biological Process	GO:1990785	response to water-immersion restraint stress	Foxo4	IEP		Rat	PMID:23079979|RGD:10402359
Biological Process	GO:0048863	stem cell differentiation	FOXO4	IMP		Human	PMID:22972301

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern