Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FOXP2
  • Mouse genes Foxp2
  • Rat genes Foxp2
  • Zfish genes foxp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	FOXP2	IDA		Human	PMID:16407075
Molecular Function	GO:0003677	DNA binding	Foxp2	IDA		Mouse	PMID:14701752
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXP2	IDA		Human	PMID:18987363
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxp2	IDA		Mouse	PMID:17428829
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Foxp2	IMP		Mouse	MGI:MGI:3606794|PMID:14701752
Molecular Function	GO:0042802	identical protein binding	FOXP2	IPI	UniProtKB:O15409	Human	PMID:16407075
Molecular Function	GO:0042802	identical protein binding	FOXP2	IPI	UniProtKB:O15409	Human	PMID:24893771
Molecular Function	GO:0042802	identical protein binding	FOXP2	IPI	UniProtKB:O15409	Human	PMID:25609649
Molecular Function	GO:0042802	identical protein binding	Foxp2	IPI	PR:P58463	Mouse	PMID:14701752
Molecular Function	GO:0050681	nuclear androgen receptor binding	Foxp2	IPI	RGD:2147	Rat	PMID:25247470|RGD:11536003
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q8IVH2	Human	PMID:19907493
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q9H334	Human	PMID:19907493
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:P56545	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q13363-2	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q9H334	Human	PMID:24893771
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q8IVH2	Human	PMID:25027557
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q9H334	Human	PMID:25027557
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:O00560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:P24863	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:P56545	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q08117	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q13363-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q13526	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q86V42	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q96A04	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q8IVH2	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q9H334	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q9H334	Human	PMID:25853299
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q9H334	Human	PMID:26647308
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q13363-2	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:P56545-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q00526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q13526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FOXP2	IPI	UniProtKB:Q96A04	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Foxp2	IPI	PR:P58462	Mouse	PMID:14701752
Molecular Function	GO:0005515	protein binding	Foxp2	IPI	PR:Q9DBY0	Mouse	PMID:14701752
Molecular Function	GO:0042803	protein homodimerization activity	FOXP2	IDA		Human	PMID:16407075
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Foxp2	IMP		Mouse	MGI:MGI:3606794|PMID:14701752
Molecular Function	GO:0043565	sequence-specific DNA binding	FOXP2	IDA		Human	PMID:18987363
Molecular Function	GO:0001221	transcription coregulator binding	Foxp2	IPI	UniProtKB:O88712	Mouse	MGI:MGI:3606794|PMID:14701752
Cellular Component	GO:0005634	nucleus	Foxp2	IDA		Mouse	PMID:22133810
Biological Process	GO:0043010	camera-type eye development	Foxp2	IMP	MGI:MGI:3723630	Mouse	PMID:17619227
Biological Process	GO:0021757	caudate nucleus development	FOXP2	IMP		Human	PMID:11872605
Biological Process	GO:0021702	cerebellar Purkinje cell differentiation	Foxp2	IMP	MGI:MGI:3778383	Mouse	PMID:22133810
Biological Process	GO:0021549	cerebellum development	Foxp2	IMP	MGI:MGI:3584266	Mouse	PMID:15983371
Biological Process	GO:0021549	cerebellum development	Foxp2	IMP	MGI:MGI:3723630	Mouse	PMID:17619227
Biological Process	GO:0021987	cerebral cortex development	FOXP2	IEP		Human	PMID:18987363
Biological Process	GO:0009790	embryo development	Foxp2	IGI	MGI:MGI:1914004	Mouse	PMID:17428829
Biological Process	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	Foxp2	IGI	MGI:MGI:1914004	Mouse	PMID:17428829
Biological Process	GO:0030900	forebrain development	Foxp2	IEP		Rat	PMID:12815709|RGD:11536004
Biological Process	GO:0010467	gene expression	Foxp2	IMP	MGI:MGI:3778383	Mouse	PMID:22133810
Biological Process	GO:0040007	growth	Foxp2	IMP	MGI:MGI:3723630	Mouse	PMID:17619227
Biological Process	GO:0098582	innate vocalization behavior	Foxp2	IMP		Rat	PMID:23426656|RGD:11536005
Biological Process	GO:0048286	lung alveolus development	Foxp2	IMP	MGI:MGI:3584266	Mouse	PMID:17428829
Biological Process	GO:0030324	lung development	Foxp2	IGI	MGI:MGI:1914004	Mouse	PMID:17428829
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	FOXP2	IDA		Human	PMID:18987363
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Foxp2	IDA		Mouse	PMID:11358962
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Foxp2	IMP		Mouse	MGI:MGI:3606794|PMID:14701752
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Foxp2	IDA		Mouse	PMID:14701752
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Foxp2	IDA		Mouse	PMID:17428829
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Foxp2	IGI	MGI:MGI:1914004	Mouse	PMID:17428829
Biological Process	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	Foxp2	IGI	MGI:MGI:1914004	Mouse	PMID:17428829
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Foxp2	IGI	MGI:MGI:1914004	Mouse	PMID:17428829
Biological Process	GO:0009791	post-embryonic development	Foxp2	IMP	MGI:MGI:3723630	Mouse	PMID:17619227
Biological Process	GO:0021758	putamen development	FOXP2	IMP		Human	PMID:11872605
Biological Process	GO:0045471	response to ethanol	foxp2	IDA		Zfish	PMID:23800254
Biological Process	GO:0033574	response to testosterone	Foxp2	IEP		Rat	PMID:25247470|RGD:11536003
Biological Process	GO:0060013	righting reflex	Foxp2	IMP	MGI:MGI:3723630	Mouse	PMID:17619227
Biological Process	GO:0007519	skeletal muscle tissue development	Foxp2	IGI	MGI:MGI:1914004	Mouse	PMID:17428829
Biological Process	GO:0048745	smooth muscle tissue development	Foxp2	IGI	MGI:MGI:1914004	Mouse	PMID:17428829
Biological Process	GO:0042297	vocal learning	Foxp2	IMP	MGI:MGI:3584266	Mouse	PMID:15983371
Biological Process	GO:0071625	vocalization behavior	Foxp2	IMP	MGI:MGI:3778383	Mouse	PMID:22133810

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern