Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FRS2
  • Mouse genes Frs2
  • Rat genes Frs2
  • Zfish genes frs2a,frs2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Frs2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	FRS2	IPI	UniProtKB:P16092	Human	PMID:9660748
Molecular Function	GO:0005168	neurotrophin TRKA receptor binding	FRS2	IPI	UniProtKB:P04629	Human	PMID:15488758
Molecular Function	GO:0005515	protein binding	FRS2	IPI	UniProtKB:P11362	Human	PMID:21765395
Molecular Function	GO:0005515	protein binding	FRS2	IPI	UniProtKB:Q06124	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	FRS2	IPI	UniProtKB:P11362	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	FRS2	IPI	UniProtKB:Q06124	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	FRS2	IPI	UniProtKB:Q06124	Human	PMID:9632781
Molecular Function	GO:0005515	protein binding	FRS2	IPI	UniProtKB:P11362	Human	PMID:9660748
Molecular Function	GO:0005515	protein binding	Frs2	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:5553227|PMID:23452850
Molecular Function	GO:0005515	protein binding	Frs2	IPI	PR:Q62245	Mouse	PMID:9182757
Molecular Function	GO:0005515	protein binding	Frs2	IPI	PR:Q60631	Mouse	PMID:16339969
Molecular Function	GO:0005515	protein binding	Frs2	IPI	PR:Q60631	Mouse	PMID:9182757
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Frs2	IDA		Mouse	PMID:9182757
Cellular Component	GO:0005912	adherens junction	FRS2	IDA		Human	PMID:25468996
Cellular Component	GO:0005911	cell-cell junction	Frs2	IDA		Mouse	PMID:23782834
Cellular Component	GO:0005737	cytoplasm	Frs2	IDA		Mouse	PMID:9182757
Cellular Component	GO:0005737	cytoplasm	Frs2	IDA		Mouse	PMID:15736129
Cellular Component	GO:0005886	plasma membrane	Frs2	IDA		Mouse	PMID:15736129
Cellular Component	GO:0005886	plasma membrane	Frs2	IDA		Mouse	PMID:9182757
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	Frs2	IMP	MGI:MGI:3580390	Mouse	PMID:15870281
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Frs2	IMP		Rat	PMID:28947594|RGD:13524616
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FRS2	IGI	UniProtKB:P16092	Human	PMID:9660748
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Frs2	IGI	MGI:MGI:95805	Mouse	PMID:11585837
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Frs2	IGI	UniProtKB:Q9UC54	Mouse	PMID:11585837
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Frs2	IMP	MGI:MGI:3045749,MGI:MGI:3768912	Mouse	PMID:23136392
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Frs2	IGI	MGI:MGI:98354	Mouse	PMID:11585837
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Frs2	IGI	MGI:MGI:95516	Mouse	PMID:17868091
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Frs2	IGI	MGI:MGI:95518	Mouse	PMID:15870281
Biological Process	GO:0030900	forebrain development	Frs2	IMP	MGI:MGI:3521833	Mouse	PMID:16239343
Biological Process	GO:0001702	gastrulation with mouth forming second	Frs2	IMP	MGI:MGI:3580390	Mouse	PMID:15870281
Biological Process	GO:0002088	lens development in camera-type eye	Frs2	IMP	MGI:MGI:3045749,MGI:MGI:3768912	Mouse	PMID:23136392
Biological Process	GO:0070307	lens fiber cell development	Frs2	IMP	MGI:MGI:3045749,MGI:MGI:3768912	Mouse	PMID:23136392
Biological Process	GO:0070307	lens fiber cell development	Frs2	IGI	MGI:MGI:97385	Mouse	PMID:23136392
Biological Process	GO:0046619	lens placode formation involved in camera-type eye formation	Frs2	IMP	MGI:MGI:3521833	Mouse	PMID:15569927
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	FRS2	IGI	UniProtKB:O75084	Human	PMID:23939491
Biological Process	GO:0007405	neuroblast proliferation	Frs2	IGI	MGI:MGI:95516	Mouse	PMID:16239343
Biological Process	GO:0007405	neuroblast proliferation	Frs2	IMP	MGI:MGI:3521833	Mouse	PMID:16239343
Biological Process	GO:0001759	organ induction	Frs2	IMP	MGI:MGI:3521833	Mouse	PMID:15569927
Biological Process	GO:0043410	positive regulation of MAPK cascade	Frs2	IMP	MGI:MGI:3689997,MGI:MGI:3768912	Mouse	PMID:18184727
Biological Process	GO:0043410	positive regulation of MAPK cascade	Frs2	IMP	MGI:MGI:3521833	Mouse	PMID:15569927
Biological Process	GO:0043410	positive regulation of MAPK cascade	Frs2	IMP	MGI:MGI:3580390	Mouse	PMID:15870281
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Frs2	IMP		Rat	PMID:28947594|RGD:13524616
Biological Process	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	Frs2	IMP	MGI:MGI:3689997,MGI:MGI:3768912	Mouse	PMID:18184727
Biological Process	GO:0042981	regulation of apoptotic process	Frs2	IMP	MGI:MGI:3768913	Mouse	PMID:23782834
Biological Process	GO:0042981	regulation of apoptotic process	Frs2	IMP	MGI:MGI:3768912	Mouse	PMID:23782834
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Frs2	IMP	MGI:MGI:3689997,MGI:MGI:3768912	Mouse	PMID:18184727
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Frs2	IMP	MGI:MGI:3768913	Mouse	PMID:23782834
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Frs2	IDA		Mouse	PMID:9182757
Biological Process	GO:0003281	ventricular septum development	Frs2	IMP	MGI:MGI:2654594,MGI:MGI:3768912	Mouse	PMID:17868091

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern