Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FRZB
  • Mouse genes Frzb
  • Rat genes Frzb
  • Zfish genes frzb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Frzb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	FRZB	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Frzb	IPI	UniProtKB:O70624	Mouse	MGI:MGI:3842073|PMID:19188438
Molecular Function	GO:0005515	protein binding	Frzb	IPI	UniProtKB:P09615	Mouse	PMID:9096311
Molecular Function	GO:0017147	Wnt-protein binding	Frzb	IDA		Mouse	MGI:MGI:707948|PMID:9178261
Molecular Function	GO:0017147	Wnt-protein binding	Frzb	IPI	PR:P27467	Mouse	PMID:17462603
Cellular Component	GO:0005615	extracellular space	FRZB	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	Frzb	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Biological Process	GO:0035988	chondrocyte proliferation	frzb	IMP	ZFIN:ZDB-MRPHLNO-131025-1	Zfish	PMID:23806211
Biological Process	GO:0090103	cochlea morphogenesis	Frzb	IGI	MGI:MGI:98958	Mouse	PMID:17433286
Biological Process	GO:0060029	convergent extension involved in organogenesis	Frzb	IGI	MGI:MGI:98958	Mouse	PMID:17433286
Biological Process	GO:0002064	epithelial cell development	Frzb	IDA		Mouse	PMID:19562671
Biological Process	GO:0070365	hepatocyte differentiation	Frzb	IDA		Mouse	PMID:19562671
Biological Process	GO:0042472	inner ear morphogenesis	Frzb	IDA		Mouse	PMID:18991062
Biological Process	GO:0042472	inner ear morphogenesis	Frzb	IGI	MGI:MGI:98958	Mouse	PMID:18991062
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	FRZB	IDA		Human	PMID:17471511
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Frzb	IGI	MGI:MGI:98956	Mouse	PMID:19961844
Biological Process	GO:0061037	negative regulation of cartilage development	Frzb	IGI	MGI:MGI:98958	Mouse	PMID:18991062
Biological Process	GO:0010721	negative regulation of cell development	Frzb	IDA		Mouse	PMID:19562671
Biological Process	GO:0030308	negative regulation of cell growth	FRZB	IDA		Human	PMID:20208569
Biological Process	GO:0008285	negative regulation of cell population proliferation	FRZB	IDA		Human	PMID:20208569
Biological Process	GO:0070367	negative regulation of hepatocyte differentiation	Frzb	IDA		Mouse	PMID:19562671
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	FRZB	IDA		Human	PMID:20208569
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Frzb	IDA		Mouse	MGI:MGI:707948|PMID:9178261
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Frzb	IGI	MGI:MGI:98958	Mouse	PMID:17433286
Biological Process	GO:0014033	neural crest cell differentiation	Frzb	IEP		Mouse	MGI:MGI:1349347|PMID:10654605
Biological Process	GO:0043065	positive regulation of apoptotic process	FRZB	IGI	UniProtKB:P27467	Human	PMID:18166153
Biological Process	GO:0045600	positive regulation of fat cell differentiation	FRZB	IDA		Human	PMID:12055200
Biological Process	GO:0061053	somite development	Frzb	IEP		Mouse	MGI:MGI:1349347|PMID:10654605
Biological Process	GO:0001944	vasculature development	frzb	IMP	ZFIN:ZDB-MRPHLNO-210921-4	Zfish	PMID:33245093

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern