Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Fscn1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FSCN1
- Mouse genes Fscn1
- Rat genes Fscn1
- Zfish genes fscn1a,fscn1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fscn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	FSCN1	IDA		Human	PMID:20393565
Molecular Function	GO:0003779	actin binding	FSCN1	IDA		Human	PMID:8999969
Molecular Function	GO:0003779	actin binding	Fscn1	IDA		Rat	PMID:8769857\|RGD:2317774
Molecular Function	GO:0051015	actin filament binding	FSCN1	IDA		Human	PMID:17671164
Molecular Function	GO:0051015	actin filament binding	FSCN1	IDA		Human	PMID:21685497
Molecular Function	GO:0051015	actin filament binding	FSCN1	IDA		Human	PMID:8999969
Molecular Function	GO:0051015	actin filament binding	Fscn1	IMP		Mouse	PMID:17671164
Molecular Function	GO:0051015	actin filament binding	fscn1a	IMP		Zfish	PMID:27545838
Molecular Function	GO:0045296	cadherin binding	FSCN1	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	FSCN1	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	FSCN1	IPI	UniProtKB:P40692	Human	PMID:20603015
Molecular Function	GO:0005515	protein binding	FSCN1	IPI	UniProtKB:P63104	Human	PMID:20603015
Molecular Function	GO:0005515	protein binding	FSCN1	IPI	UniProtKB:Q9BXW9	Human	PMID:20603015
Molecular Function	GO:0005515	protein binding	FSCN1	IPI	UniProtKB:Q9ULL4	Human	PMID:21706053
Molecular Function	GO:0005515	protein binding	Fscn1	IPI	UniProtKB:P68135	Mouse	MGI:MGI:5916639\|PMID:24633326
Molecular Function	GO:0005515	protein binding	Fscn1	IPI	UniProtKB:Q9QY40	Mouse	MGI:MGI:5487516\|PMID:21706053
Molecular Function	GO:0005515	protein binding	Fscn1	IPI	PR:Q9D394	Mouse	PMID:24720729
Molecular Function	GO:0005515	protein binding	Fscn1	IPI	RGD:70487	Rat	PMID:8794867\|RGD:2317776
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	fscn1a	IMP		Zfish	PMID:27545838
Molecular Function	GO:0003723	RNA binding	FSCN1	HDA		Human	PMID:22658674
Molecular Function	GO:0005102	signaling receptor binding	fscn1a	IMP		Zfish	PMID:27545838
Cellular Component	GO:0015629	actin cytoskeleton	FSCN1	IDA		Human	PMID:3525578
Cellular Component	GO:0031253	cell projection membrane	FSCN1	IDA		Human	PMID:9571235
Cellular Component	GO:0005911	cell-cell junction	FSCN1	IDA		Human	PMID:9571235
Cellular Component	GO:0005737	cytoplasm	FSCN1	IDA		Human	PMID:9571235
Cellular Component	GO:0005737	cytoplasm	Fscn1	IDA		Rat	PMID:7933116\|RGD:2317772
Cellular Component	GO:0005856	cytoskeleton	FSCN1	IDA		Human	PMID:9571235
Cellular Component	GO:0005829	cytosol	FSCN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Fscn1	IDA		Rat	PMID:7933116\|RGD:2317772
Cellular Component	GO:0070062	extracellular exosome	FSCN1	HDA		Human	PMID:20458337
Cellular Component	GO:0030175	filopodium	FSCN1	IDA		Human	PMID:20137952
Cellular Component	GO:0030175	filopodium	FSCN1	IDA		Human	PMID:3525578
Cellular Component	GO:0030175	filopodium	Fscn1	IDA		Mouse	MGI:MGI:5603691\|PMID:24720729
Cellular Component	GO:0030175	filopodium	Fscn1	IDA		Mouse	PMID:15294161
Cellular Component	GO:0030175	filopodium	Fscn1	IDA		Mouse	PMID:17671164
Cellular Component	GO:0030175	filopodium	Fscn1	IDA		Rat	PMID:8769857\|RGD:2317774
Cellular Component	GO:0030426	growth cone	Fscn1	IDA		Mouse	MGI:MGI:5603691\|PMID:24720729
Cellular Component	GO:0030426	growth cone	Fscn1	IDA		Rat	PMID:7933116\|RGD:2317772
Cellular Component	GO:0030027	lamellipodium	Fscn1	IDA		Mouse	MGI:MGI:5603691\|PMID:24720729
Cellular Component	GO:0030027	lamellipodium	Fscn1	IDA		Rat	PMID:18855019\|RGD:2317768
Cellular Component	GO:0044393	microspike	FSCN1	IDA		Human	PMID:20137952
Cellular Component	GO:0044393	microspike	FSCN1	IDA		Human	PMID:3525578
Cellular Component	GO:0044393	microspike	FSCN1	IDA		Human	PMID:9571235
Cellular Component	GO:0005902	microvillus	FSCN1	IDA		Human	PMID:9571235
Cellular Component	GO:0005902	microvillus	Fscn1	IDA		Rat	PMID:18855019\|RGD:2317768
Cellular Component	GO:0043209	myelin sheath	Fscn1	HDA		Mouse	MGI:MGI:3834050\|PMID:17634366
Cellular Component	GO:0005886	plasma membrane	Fscn1	IDA		Rat	PMID:18855019\|RGD:2317768
Cellular Component	GO:0002102	podosome	FSCN1	IDA		Human	PMID:20137952
Cellular Component	GO:0001726	ruffle	FSCN1	IDA		Human	PMID:3525578
Cellular Component	GO:0001726	ruffle	Fscn1	IDA		Rat	PMID:7657718\|RGD:2317778
Cellular Component	GO:0001725	stress fiber	FSCN1	IDA		Human	PMID:3525578
Cellular Component	GO:0001725	stress fiber	Fscn1	IDA		Rat	PMID:7657718\|RGD:2317778
Biological Process	GO:0030036	actin cytoskeleton organization	FSCN1	IDA		Human	PMID:9571235
Biological Process	GO:0051017	actin filament bundle assembly	FSCN1	IDA		Human	PMID:20393565
Biological Process	GO:0051017	actin filament bundle assembly	Fscn1	IDA		Mouse	PMID:7738015
Biological Process	GO:0051017	actin filament bundle assembly	Fscn1	IDA		Mouse	PMID:17671164
Biological Process	GO:0051017	actin filament bundle assembly	Fscn1	IDA		Rat	PMID:8769857\|RGD:2317774
Biological Process	GO:0016477	cell migration	FSCN1	IMP		Human	PMID:20393565
Biological Process	GO:0016477	cell migration	Fscn1	IMP		Mouse	MGI:MGI:4888112\|PMID:20393565
Biological Process	GO:0048870	cell motility	FSCN1	IDA		Human	PMID:9571235
Biological Process	GO:0007043	cell-cell junction assembly	FSCN1	IDA		Human	PMID:9571235
Biological Process	GO:0071460	cellular response to cell-matrix adhesion	Fscn1	IEP		Rat	PMID:7657718\|RGD:2317778
Biological Process	GO:0048565	digestive tract development	fscn1a	IMP		Zfish	PMID:27545838
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	fscn1a	IMP	ZFIN:ZDB-GENO-150528-5	Zfish	PMID:25607881
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	fscn1a	IGI	ZFIN:ZDB-GENE-020102-1	Zfish	PMID:25607881
Biological Process	GO:0031018	endocrine pancreas development	fscn1a	IMP		Zfish	PMID:27545838
Biological Process	GO:0007492	endoderm development	fscn1a	IMP		Zfish	PMID:27545838
Biological Process	GO:0007492	endoderm development	fscn1a	IMP	ZFIN:ZDB-MRPHLNO-160929-1	Zfish	PMID:27545838
Biological Process	GO:0090504	epiboly	fscn1a	IMP	ZFIN:ZDB-MRPHLNO-160929-1	Zfish	PMID:27545838
Biological Process	GO:0035089	establishment of apical/basal cell polarity	FSCN1	IDA		Human	PMID:9571235
Biological Process	GO:0001889	liver development	Fscn1	IEP		Rat	PMID:18855019\|RGD:2317768
Biological Process	GO:0001889	liver development	fscn1a	IMP		Zfish	PMID:27545838
Biological Process	GO:0030035	microspike assembly	FSCN1	IMP		Human	PMID:20137952
Biological Process	GO:0030035	microspike assembly	FSCN1	IDA		Human	PMID:9571235
Biological Process	GO:0001755	neural crest cell migration	fscn1a	IMP	ZFIN:ZDB-MRPHLNO-160929-1	Zfish	PMID:27545838
Biological Process	GO:0001755	neural crest cell migration	fscn1a	IMP	ZFIN:ZDB-GENO-150528-5	Zfish	PMID:25607881
Biological Process	GO:0001755	neural crest cell migration	fscn1a	IMP	ZFIN:ZDB-MRPHLNO-160929-1	Zfish	PMID:28005909
Biological Process	GO:1903045	neural crest cell migration involved in sympathetic nervous system development	fscn1a	IMP	ZFIN:ZDB-GENO-150528-5	Zfish	PMID:25607881
Biological Process	GO:1903045	neural crest cell migration involved in sympathetic nervous system development	fscn1a	IGI	ZFIN:ZDB-GENE-020102-1	Zfish	PMID:25607881
Biological Process	GO:0030046	parallel actin filament bundle assembly	FSCN1	IDA		Human	PMID:21685497
Biological Process	GO:0060037	pharyngeal system development	fscn1a	IMP		Zfish	PMID:27545838
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly	FSCN1	IDA		Human	PMID:20137952
Biological Process	GO:0051491	positive regulation of filopodium assembly	FSCN1	IMP		Human	PMID:20137952
Biological Process	GO:0051491	positive regulation of filopodium assembly	FSCN1	IDA		Human	PMID:21685497
Biological Process	GO:0051491	positive regulation of filopodium assembly	FSCN1	IDA		Human	PMID:9571235
Biological Process	GO:0051491	positive regulation of filopodium assembly	Fscn1	IMP		Mouse	MGI:MGI:6316567\|PMID:21685497
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	FSCN1	IDA		Human	PMID:9571235
Biological Process	GO:0071803	positive regulation of podosome assembly	FSCN1	IDA		Human	PMID:20137952
Biological Process	GO:0031623	receptor internalization	fscn1a	IMP		Zfish	PMID:27545838
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	FSCN1	IDA		Human	PMID:20137952
Biological Process	GO:0032534	regulation of microvillus assembly	FSCN1	IDA		Human	PMID:9571235
Biological Process	GO:1900107	regulation of nodal signaling pathway	fscn1a	IMP	ZFIN:ZDB-MRPHLNO-160929-1	Zfish	PMID:27545838

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.