Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FURIN
  • Mouse genes Furin
  • Rat genes Furin
  • Zfish genes furina,furinb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Furin

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	FURIN	IDA		Human	PMID:17010968
Molecular Function	GO:0004175	endopeptidase activity	FURIN	IMP		Human	PMID:20489134
Molecular Function	GO:0004175	endopeptidase activity	FURIN	IDA		Human	PMID:31091448
Molecular Function	GO:0004175	endopeptidase activity	FURIN	IDA		Human	PMID:9242664
Molecular Function	GO:1904399	heparan sulfate binding	FURIN	IDA		Human	PMID:34699015
Molecular Function	GO:0008201	heparin binding	FURIN	IDA		Human	PMID:34699015
Molecular Function	GO:0140677	molecular function activator activity	FURIN	IDA		Human	PMID:9325052
Molecular Function	GO:0048406	nerve growth factor binding	FURIN	IDA		Human	PMID:8615794
Molecular Function	GO:0008233	peptidase activity	FURIN	IDA		Human	PMID:10526337
Molecular Function	GO:0008233	peptidase activity	FURIN	IDA		Human	PMID:15082773
Molecular Function	GO:0008233	peptidase activity	FURIN	IDA		Human	PMID:15606899
Molecular Function	GO:0008233	peptidase activity	FURIN	IDA		Human	PMID:17938254
Molecular Function	GO:0042277	peptide binding	FURIN	IDA		Human	PMID:8940009
Molecular Function	GO:0002020	protease binding	FURIN	IPI	UniProtKB:O75173	Human	PMID:14744861
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:P50281	Human	PMID:20608975
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:P50281	Human	PMID:21152186
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:Q9H239	Human	PMID:21152186
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:O14793	Human	PMID:23829672
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:O14793	Human	PMID:25543063
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:P0DTC2	Human	PMID:32512386
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:K9N5Q8	Human	PMID:32703818
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:P0DTC2	Human	PMID:32703818
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:Q91QT1	Human	PMID:32703818
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:K9N5Q8	Human	PMID:33037310
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:P0DTC2	Human	PMID:33037310
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:P0DTC2	Human	PMID:33043282
Molecular Function	GO:0005515	protein binding	FURIN	IPI	UniProtKB:P0DTC2	Human	PMID:33417835
Molecular Function	GO:0005515	protein binding	Furin	IPI	PR:Q8BTM8	Mouse	PMID:9412467
Molecular Function	GO:0004252	serine-type endopeptidase activity	FURIN	IDA		Human	PMID:10567353
Molecular Function	GO:0004252	serine-type endopeptidase activity	FURIN	IMP		Human	PMID:11799113
Molecular Function	GO:0004252	serine-type endopeptidase activity	FURIN	IDA		Human	PMID:1438214
Molecular Function	GO:0004252	serine-type endopeptidase activity	FURIN	IDA		Human	PMID:1644824
Molecular Function	GO:0004252	serine-type endopeptidase activity	FURIN	IDA		Human	PMID:21763278
Molecular Function	GO:0004252	serine-type endopeptidase activity	FURIN	IDA		Human	PMID:7737999
Molecular Function	GO:0004252	serine-type endopeptidase activity	FURIN	IDA		Human	PMID:8615794
Molecular Function	GO:0004252	serine-type endopeptidase activity	FURIN	IMP		Human	PMID:9130696
Molecular Function	GO:0004252	serine-type endopeptidase activity	Furin	EXP		Mouse	MGI:MGI:2448438|PMID:12447384
Molecular Function	GO:0004252	serine-type endopeptidase activity	Furin	IMP		Rat	PMID:15194465|RGD:1582619
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	FURIN	IDA		Human	PMID:10567353
Molecular Function	GO:0008236	serine-type peptidase activity	FURIN	IDA		Human	PMID:9325052
Cellular Component	GO:0009986	cell surface	FURIN	IDA		Human	PMID:16537537
Cellular Component	GO:0005783	endoplasmic reticulum	FURIN	IGI	UniProtKB:Q6ZVN8	Human	PMID:17938254
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Furin	IDA		Rat	PMID:16541018|RGD:1582625
Cellular Component	GO:0070062	extracellular exosome	FURIN	HDA		Human	PMID:19199708
Cellular Component	GO:0031985	Golgi cisterna	Furin	IDA		Rat	PMID:16541018|RGD:1582625
Cellular Component	GO:0000139	Golgi membrane	FURIN	IMP		Human	PMID:11799113
Cellular Component	GO:0000139	Golgi membrane	FURIN	IMP		Human	PMID:9130696
Cellular Component	GO:0016020	membrane	FURIN	HDA		Human	PMID:19946888
Cellular Component	GO:0045121	membrane raft	FURIN	IDA		Human	PMID:17010968
Cellular Component	GO:0005886	plasma membrane	Furin	IDA		Rat	PMID:16541018|RGD:1582625
Cellular Component	GO:0005802	trans-Golgi network	FURIN	IDA		Human	PMID:14744861
Cellular Component	GO:0030140	trans-Golgi network transport vesicle	FURIN	IDA		Human	PMID:15078902
Biological Process	GO:0007568	aging	Furin	IEP		Rat	PMID:16541018|RGD:1582625
Biological Process	GO:0001825	blastocyst formation	Furin	IGI	UniProtKB:Q61139	Mouse	MGI:MGI:5702364|PMID:26416966
Biological Process	GO:0051216	cartilage development	furina	IMP	ZFIN:ZDB-GENO-980202-1065	Zfish	PMID:16678149
Biological Process	GO:0051216	cartilage development	furina	IGI	ZFIN:ZDB-GENO-980202-1065,ZFIN:ZDB-MRPHLNO-060822-3	Zfish	PMID:16678149
Biological Process	GO:0051216	cartilage development	furina	IMP	ZFIN:ZDB-MRPHLNO-060822-5	Zfish	PMID:16678149
Biological Process	GO:0051216	cartilage development	furina	IGI	ZFIN:ZDB-GENO-980202-1065,ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:16678149
Biological Process	GO:0051216	cartilage development	furinb	IMP	ZFIN:ZDB-MRPHLNO-060822-3	Zfish	PMID:16678149
Biological Process	GO:0051216	cartilage development	furinb	IGI	ZFIN:ZDB-GENO-980202-1065,ZFIN:ZDB-MRPHLNO-060822-3	Zfish	PMID:16678149
Biological Process	GO:0060536	cartilage morphogenesis	furina	IMP	ZFIN:ZDB-GENO-980202-1487	Zfish	PMID:9007254
Biological Process	GO:0060536	cartilage morphogenesis	furina	IMP	ZFIN:ZDB-GENO-980202-1065	Zfish	PMID:9007254
Biological Process	GO:0071907	determination of digestive tract left/right asymmetry	furina	IMP	ZFIN:ZDB-GENO-150626-2	Zfish	PMID:25684355
Biological Process	GO:0061371	determination of heart left/right asymmetry	furina	IMP	ZFIN:ZDB-GENO-150626-2	Zfish	PMID:25684355
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	furina	IMP	ZFIN:ZDB-GENO-150626-2	Zfish	PMID:25684355
Biological Process	GO:0090472	dibasic protein processing	FURIN	IMP		Human	PMID:11799113
Biological Process	GO:0060971	embryonic heart tube left/right pattern formation	furina	IMP	ZFIN:ZDB-GENO-100813-3	Zfish	ZFIN:ZDB-PUB-100730-1
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	furina	IMP	ZFIN:ZDB-GENO-980202-1487	Zfish	PMID:21073867
Biological Process	GO:0033334	fin morphogenesis	furina	IMP	ZFIN:ZDB-GENO-980202-1487	Zfish	PMID:20419147
Biological Process	GO:0003146	heart jogging	furina	IMP	ZFIN:ZDB-GENO-150626-2	Zfish	PMID:25684355
Biological Process	GO:0001947	heart looping	furina	IMP	ZFIN:ZDB-GENO-150626-2	Zfish	PMID:25684355
Biological Process	GO:0001947	heart looping	furina	IMP	ZFIN:ZDB-GENO-100813-3	Zfish	ZFIN:ZDB-PUB-100730-1
Biological Process	GO:0001947	heart looping	furina	IMP	ZFIN:ZDB-GENO-100813-3	Zfish	PMID:19506109
Biological Process	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	FURIN	IDA		Human	PMID:16912035
Biological Process	GO:0032911	negative regulation of transforming growth factor beta1 production	FURIN	IMP		Human	PMID:15899807
Biological Process	GO:0032902	nerve growth factor production	FURIN	IDA		Human	PMID:8615794
Biological Process	GO:0043043	peptide biosynthetic process	FURIN	IDA		Human	PMID:8262946
Biological Process	GO:0016486	peptide hormone processing	FURIN	IDA		Human	PMID:9242664
Biological Process	GO:0030335	positive regulation of cell migration	Furin	IMP		Rat	PMID:15194465|RGD:1582619
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Furin	IMP		Rat	PMID:15194465|RGD:1582619
Biological Process	GO:1901394	positive regulation of transforming growth factor beta1 activation	FURIN	IDA		Human	PMID:7737999
Biological Process	GO:0046598	positive regulation of viral entry into host cell	FURIN	IDA		Human	PMID:32362314
Biological Process	GO:0051604	protein maturation	FURIN	IDA		Human	PMID:31091448
Biological Process	GO:0016485	protein processing	FURIN	IDA		Human	PMID:15606899
Biological Process	GO:0016485	protein processing	FURIN	IDA		Human	PMID:10526337
Biological Process	GO:0016485	protein processing	FURIN	IDA		Human	PMID:10567353
Biological Process	GO:0016485	protein processing	FURIN	IDA		Human	PMID:14744861
Biological Process	GO:0016485	protein processing	FURIN	IMP		Human	PMID:15899807
Biological Process	GO:0016485	protein processing	FURIN	IDA		Human	PMID:17938254
Biological Process	GO:0016485	protein processing	FURIN	IDA		Human	PMID:9242664
Biological Process	GO:0016485	protein processing	Furin	IMP	MGI:MGI:3700008	Mouse	PMID:23918928
Biological Process	GO:0016485	protein processing	Furin	IMP	MGI:MGI:3700008	Mouse	PMID:21147780
Biological Process	GO:0016485	protein processing	Furin	IDA		Mouse	PMID:20530870
Biological Process	GO:0016485	protein processing	Furin	IDA		Rat	PMID:11861638|RGD:633598
Biological Process	GO:0016485	protein processing	Furin	IMP		Rat	PMID:15194465|RGD:1582619
Biological Process	GO:0032374	regulation of cholesterol transport	Furin	IMP	MGI:MGI:3700008	Mouse	PMID:21147780
Biological Process	GO:0052548	regulation of endopeptidase activity	FURIN	IDA		Human	PMID:14744861
Biological Process	GO:0042176	regulation of protein catabolic process	FURIN	IMP		Human	PMID:15899807
Biological Process	GO:0009966	regulation of signal transduction	Furin	IDA		Mouse	PMID:17936261
Biological Process	GO:0009617	response to bacterium	furina	IMP	ZFIN:ZDB-MRPHLNO-140403-1	Zfish	PMID:25624351
Biological Process	GO:0032940	secretion by cell	FURIN	IDA		Human	PMID:8615794
Biological Process	GO:0006465	signal peptide processing	FURIN	IDA		Human	PMID:16912035
Biological Process	GO:0019058	viral life cycle	FURIN	IEP		Human	PMID:8940009
Biological Process	GO:0031638	zymogen activation	FURIN	IMP		Human	PMID:11799113
Biological Process	GO:0031638	zymogen activation	FURIN	IMP		Human	PMID:9130696

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern