Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Fus

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FUS
- Mouse genes Fus
- Rat genes Fus
- Zfish genes fus
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fus

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	FUS	IDA		Human	PMID:25453086
Molecular Function	GO:0003682	chromatin binding	FUS	IDA		Human	PMID:27731383
Molecular Function	GO:0042802	identical protein binding	FUS	IPI	UniProtKB:P35637	Human	PMID:18509338
Molecular Function	GO:0042802	identical protein binding	FUS	IPI	UniProtKB:P35637	Human	PMID:23975937
Molecular Function	GO:0042802	identical protein binding	FUS	IPI	UniProtKB:P35637	Human	PMID:29439243
Molecular Function	GO:0042802	identical protein binding	FUS	IPI	UniProtKB:P35637	Human	PMID:29610493
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Fus	IPI	RGD:2736	Rat	PMID:19103256\|RGD:9685716
Molecular Function	GO:0140693	molecular condensate scaffold activity	FUS	IDA		Human	PMID:26317470
Molecular Function	GO:0140693	molecular condensate scaffold activity	FUS	IDA		Human	PMID:26455390
Molecular Function	GO:0140693	molecular condensate scaffold activity	FUS	IDA		Human	PMID:29677513
Molecular Function	GO:0003730	mRNA 3'-UTR binding	Fus	IDA		Mouse	PMID:27378374
Molecular Function	GO:0031489	myosin V binding	Fus	IPI	RGD:3143	Rat	PMID:19103256\|RGD:9685716
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Fus	IDA		Rat	PMID:9440806\|RGD:9685715
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	Fus	IPI	RGD:11250	Rat	PMID:9440806\|RGD:9685715
Molecular Function	GO:0046966	nuclear thyroid hormone receptor binding	Fus	IDA		Rat	PMID:9440806\|RGD:9685715
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q99873	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P45481	Human	PMID:18509338
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q09472	Human	PMID:18509338
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q92993	Human	PMID:18509338
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q96FW1	Human	PMID:18954305
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q9H3D4	Human	PMID:20085233
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P38159	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q01844	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q92804	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q15149	Human	PMID:22240165
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q92973-2	Human	PMID:22778397
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q99873	Human	PMID:23152885
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q99873-3	Human	PMID:23152885
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q9NRR4	Human	PMID:23232809
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P97801	Human	PMID:23681068
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q01844	Human	PMID:23975937
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q92804	Human	PMID:23975937
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P08621	Human	PMID:26124092
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P24928	Human	PMID:26124092
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P38159	Human	PMID:27460707
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q92804	Human	PMID:27460707
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q13148	Human	PMID:27615052
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P43243	Human	PMID:27731383
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q15424	Human	PMID:27731383
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q9UKM9	Human	PMID:30354839
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:O15479	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:O60739	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:O75815	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P18206-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P19793	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P48730-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P49841-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:P60896	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q04206-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q05586	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q13191	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q8N488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q8NHS9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q96FW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q9BUL9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q9BYU1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q9UKA9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:Q8N488	Human	PMID:34316702
Molecular Function	GO:0005515	protein binding	FUS	IPI	UniProtKB:O75494	Human	PMID:9774382
Molecular Function	GO:0005515	protein binding	Fus	IPI	UniProtKB:Q6UWE0	Mouse	MGI:MGI:6368049\|PMID:27615052
Molecular Function	GO:0005515	protein binding	Fus	IPI	UniProtKB:P97801	Mouse	MGI:MGI:5503253\|PMID:23681068
Molecular Function	GO:0003723	RNA binding	FUS	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	FUS	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	FUS	IDA		Human	PMID:27378374
Molecular Function	GO:0003723	RNA binding	FUS	EXP		Human	PMID:29677513
Molecular Function	GO:0003723	RNA binding	Fus	IDA		Mouse	PMID:27378374
Molecular Function	GO:0003713	transcription coactivator activity	FUS	IDA		Human	PMID:21909421
Cellular Component	GO:0005737	cytoplasm	Fus	IDA		Mouse	PMID:12950080
Cellular Component	GO:0005737	cytoplasm	Fus	IDA		Rat	PMID:15843054\|RGD:9685711
Cellular Component	GO:0030425	dendrite	Fus	IDA		Rat	PMID:15843054\|RGD:9685711
Cellular Component	GO:0043197	dendritic spine	Fus	IDA		Rat	PMID:15843054\|RGD:9685711
Cellular Component	GO:0044327	dendritic spine head	Fus	IDA		Rat	PMID:15843054\|RGD:9685711
Cellular Component	GO:0043232	intracellular non-membrane-bounded organelle	FUS	IDA		Human	PMID:21541367
Cellular Component	GO:0043232	intracellular non-membrane-bounded organelle	FUS	IDA		Human	PMID:22579281
Cellular Component	GO:0043232	intracellular non-membrane-bounded organelle	FUS	IDA		Human	PMID:26317470
Cellular Component	GO:0043025	neuronal cell body	Fus	IDA		Rat	PMID:15843054\|RGD:9685711
Cellular Component	GO:0005654	nucleoplasm	FUS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FUS	IDA		Human	PMID:16365397
Cellular Component	GO:0005634	nucleus	FUS	IDA		Human	PMID:27731383
Cellular Component	GO:0005634	nucleus	FUS	IDA		Human	PMID:21909421
Cellular Component	GO:0005634	nucleus	Fus	IDA		Mouse	PMID:12950080
Cellular Component	GO:0043204	perikaryon	Fus	IDA		Rat	PMID:15843054\|RGD:9685711
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Fus	IDA		Rat	PMID:15843054\|RGD:9685711
Cellular Component	GO:0005844	polysome	Fus	IDA		Rat	PMID:15843054\|RGD:9685711
Biological Process	GO:1990000	amyloid fibril formation	FUS	IDA		Human	PMID:22579281
Biological Process	GO:1990000	amyloid fibril formation	FUS	EXP		Human	PMID:28942918
Biological Process	GO:0048675	axon extension	fus	IMP	ZFIN:ZDB-MRPHLNO-110823-4	Zfish	PMID:28358904
Biological Process	GO:0071277	cellular response to calcium ion	Fus	IDA		Rat	PMID:19103256\|RGD:9685716
Biological Process	GO:0010467	gene expression	Fus	IMP		Mouse	PMID:27378374
Biological Process	GO:0010467	gene expression	Fus	IGI	MGI:MGI:1917689	Mouse	PMID:27378374
Biological Process	GO:0048255	mRNA stabilization	FUS	IDA		Human	PMID:27378374
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	FUS	IDA		Human	PMID:10567410
Biological Process	GO:0051260	protein homooligomerization	FUS	IDA		Human	PMID:25453086
Biological Process	GO:0006355	regulation of DNA-templated transcription	FUS	IDA		Human	PMID:26124092
Biological Process	GO:0043484	regulation of RNA splicing	FUS	IDA		Human	PMID:25453086
Biological Process	GO:0043484	regulation of RNA splicing	FUS	IDA		Human	PMID:27731383
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	FUS	IDA		Human	PMID:25453086
Biological Process	GO:0008380	RNA splicing	FUS	IDA		Human	PMID:26124092
Biological Process	GO:0008380	RNA splicing	Fus	IMP		Mouse	PMID:27378374

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.