Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FXN
  • Mouse genes Fxn
  • Rat genes Fxn
  • Zfish genes fxn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fxn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	FXN	IDA		Human	PMID:12785837
Molecular Function	GO:0019899	enzyme binding	Fxn	IPI	RGD:621360	Rat	PMID:15247478|RGD:1304347
Molecular Function	GO:0008199	ferric iron binding	FXN	IDA		Human	PMID:12785837
Molecular Function	GO:0008199	ferric iron binding	FXN	IDA		Human	PMID:18537827
Molecular Function	GO:0008198	ferrous iron binding	FXN	IDA		Human	PMID:12785837
Molecular Function	GO:0008198	ferrous iron binding	FXN	IDA		Human	PMID:15123683
Molecular Function	GO:0008198	ferrous iron binding	FXN	IDA		Human	PMID:17285345
Molecular Function	GO:0008198	ferrous iron binding	FXN	IDA		Human	PMID:29576242
Molecular Function	GO:0004322	ferroxidase activity	FXN	IDA		Human	PMID:15641778
Molecular Function	GO:0034986	iron chaperone activity	FXN	IDA		Human	PMID:15123683
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:P22830	Human	PMID:15123683
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:P21912	Human	PMID:15961414
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:P31040	Human	PMID:15961414
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:P38646	Human	PMID:26702583
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q9H1K1|UniProtKB:Q9Y697	Human	PMID:31101807
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q9UN19	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:O75925	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q8N6K7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q8WVD3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q92828	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q96D59	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q9BVU5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q9GZS3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q9HC96	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q9NS23-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FXN	IPI	UniProtKB:Q9UN19	Human	PMID:32814053
Cellular Component	GO:0005829	cytosol	FXN	IDA		Human	PMID:17468497
Cellular Component	GO:1990221	L-cysteine desulfurase complex	FXN	IDA		Human	PMID:29491838
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	FXN	IDA		Human	PMID:21298097
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	FXN	IDA		Human	PMID:31101807
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	Fxn	IDA		Mouse	MGI:MGI:6228237|PMID:21298097
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	Fxn	IDA		Mouse	MGI:MGI:7327226|PMID:25597503
Cellular Component	GO:0005739	mitochondrion	FXN	IDA		Human	PMID:17468497
Cellular Component	GO:0005739	mitochondrion	FXN	IDA		Human	PMID:21298097
Cellular Component	GO:0005739	mitochondrion	Fxn	IDA		Mouse	PMID:17597094
Cellular Component	GO:0005739	mitochondrion	Fxn	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Fxn	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Fxn	IDA		Rat	PMID:15247478|RGD:1304347
Biological Process	GO:0044571	[2Fe-2S] cluster assembly	FXN	IDA		Human	PMID:24971490
Biological Process	GO:0044571	[2Fe-2S] cluster assembly	FXN	IDA		Human	PMID:29576242
Biological Process	GO:0044572	[4Fe-4S] cluster assembly	FXN	IDA		Human	PMID:29576242
Biological Process	GO:0044572	[4Fe-4S] cluster assembly	Fxn	IDA		Mouse	MGI:MGI:7327226|PMID:25597503
Biological Process	GO:0007628	adult walking behavior	Fxn	IMP	MGI:MGI:2177175,MGI:MGI:2177176	Mouse	PMID:9405681
Biological Process	GO:0007628	adult walking behavior	Fxn	IMP	MGI:MGI:2177177	Mouse	PMID:14985441
Biological Process	GO:0009060	aerobic respiration	Fxn	IMP	MGI:MGI:2177175,MGI:MGI:2177176	Mouse	PMID:9405681
Biological Process	GO:0009060	aerobic respiration	Fxn	IMP	MGI:MGI:2176228,MGI:MGI:2177176	Mouse	PMID:16278235
Biological Process	GO:0070301	cellular response to hydrogen peroxide	FXN	IDA		Human	PMID:15641778
Biological Process	GO:0009792	embryo development ending in birth or egg hatching	Fxn	IMP	MGI:MGI:2177162	Mouse	PMID:10767347
Biological Process	GO:0006879	intracellular iron ion homeostasis	FXN	IMP		Human	PMID:18160053
Biological Process	GO:0006879	intracellular iron ion homeostasis	Fxn	IMP	MGI:MGI:2177175,MGI:MGI:2177176	Mouse	PMID:9405681
Biological Process	GO:0018283	iron incorporation into metallo-sulfur cluster	FXN	IDA		Human	PMID:12785837
Biological Process	GO:0016226	iron-sulfur cluster assembly	FXN	IDA		Human	PMID:29491838
Biological Process	GO:0016226	iron-sulfur cluster assembly	Fxn	IMP	MGI:MGI:2176228,MGI:MGI:2177176	Mouse	PMID:17597094
Biological Process	GO:0016226	iron-sulfur cluster assembly	Fxn	IMP	MGI:MGI:2176228,MGI:MGI:2177176	Mouse	PMID:16278235
Biological Process	GO:0007005	mitochondrion organization	Fxn	IMP	MGI:MGI:2177177	Mouse	PMID:14985441
Biological Process	GO:0007005	mitochondrion organization	Fxn	IMP	MGI:MGI:2177175,MGI:MGI:2177176	Mouse	PMID:9405681
Biological Process	GO:0046716	muscle cell cellular homeostasis	Fxn	IMP	MGI:MGI:2177175,MGI:MGI:2177176	Mouse	PMID:9405681
Biological Process	GO:0043066	negative regulation of apoptotic process	FXN	IMP		Human	PMID:16608849
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Fxn	IMP	MGI:MGI:2177176,MGI:MGI:2182103	Mouse	PMID:17404227
Biological Process	GO:0046621	negative regulation of organ growth	Fxn	IMP	MGI:MGI:2177175,MGI:MGI:2177176	Mouse	PMID:9405681
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	FXN	IMP		Human	PMID:16608849
Biological Process	GO:0035265	organ growth	Fxn	IMP	MGI:MGI:2177175,MGI:MGI:2177176	Mouse	PMID:9405681
Biological Process	GO:0006119	oxidative phosphorylation	Fxn	IMP	MGI:MGI:2177176,MGI:MGI:2182103	Mouse	PMID:17404227
Biological Process	GO:0006119	oxidative phosphorylation	Fxn	IMP	MGI:MGI:2176228,MGI:MGI:2177176	Mouse	PMID:16278235
Biological Process	GO:1904234	positive regulation of aconitate hydratase activity	FXN	IMP		Human	PMID:18160053
Biological Process	GO:0045773	positive regulation of axon extension	Fxn	IMP		Rat	PMID:18809400|RGD:2306797
Biological Process	GO:0043085	positive regulation of catalytic activity	FXN	IMP		Human	PMID:15509595
Biological Process	GO:0030307	positive regulation of cell growth	FXN	IMP		Human	PMID:15509595
Biological Process	GO:0008284	positive regulation of cell population proliferation	FXN	IMP		Human	PMID:18160053
Biological Process	GO:0051349	positive regulation of lyase activity	FXN	IMP		Human	PMID:18160053
Biological Process	GO:0051349	positive regulation of lyase activity	FXN	IDA		Human	PMID:20053667
Biological Process	GO:1904231	positive regulation of succinate dehydrogenase activity	FXN	IMP		Human	PMID:18160053
Biological Process	GO:0019230	proprioception	Fxn	IMP	MGI:MGI:2177177	Mouse	PMID:14985441
Biological Process	GO:0019230	proprioception	Fxn	IMP	MGI:MGI:2177175,MGI:MGI:2177176	Mouse	PMID:11175786
Biological Process	GO:0016540	protein autoprocessing	FXN	IDA		Human	PMID:12785837
Biological Process	GO:0010722	regulation of ferrochelatase activity	FXN	IDA		Human	PMID:15123683
Biological Process	GO:0010039	response to iron ion	FXN	IMP		Human	PMID:18424449
Biological Process	GO:0014070	response to organic cyclic compound	Fxn	IEP		Rat	PMID:18809400|RGD:2306797
Biological Process	GO:0009410	response to xenobiotic stimulus	Fxn	IEP		Rat	PMID:18809400|RGD:2306797

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern