Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FXR1
  • Mouse genes Fxr1
  • Rat genes Fxr1
  • Zfish genes fxr1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fxr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140693	molecular condensate scaffold activity	Fxr1	IDA		Mouse	MGI:MGI:6446543|PMID:32328638
Molecular Function	GO:0140693	molecular condensate scaffold activity	Fxr1	IDA		Mouse	PMID:35951695
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	FXR1	IDA		Human	PMID:17382880
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	FXR1	IDA		Human	PMID:30067974
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	FXR1	IDA		Human	PMID:34731628
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	Fxr1	IDA		Mouse	MGI:MGI:5618352|PMID:25456134
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	Fxr1	IDA		Mouse	MGI:MGI:3573966|PMID:15548538
Molecular Function	GO:0003730	mRNA 3'-UTR binding	FXR1	IDA		Human	PMID:34731628
Molecular Function	GO:0003729	mRNA binding	Fxr1	IDA		Mouse	MGI:MGI:6446543|PMID:32328638
Molecular Function	GO:0003729	mRNA binding	Fxr1	IDA		Mouse	MGI:MGI:5904238|PMID:28204491
Molecular Function	GO:0003729	mRNA binding	Fxr1	IDA		Mouse	PMID:35951695
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q06787	Human	PMID:11157796
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q06787	Human	PMID:15380484
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q86X55	Human	PMID:15471871
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q96EZ8	Human	PMID:16571602
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:O00423	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:P04637	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:P07437	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:P21333	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:P51116	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q06787	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q15233	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q674X7	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q6AI12	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q86UU1	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q8WZ19	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q96CW1	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q9P209	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q9UI14	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q9Y232	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:P51116	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q06787	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q06787	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:P51116	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q06787	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:P0DTD1:PRO_0000449621	Human	PMID:32838362
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:P0DTD1:PRO_0000449621	Human	PMID:34270554
Molecular Function	GO:0005515	protein binding	FXR1	IPI	UniProtKB:Q06787	Human	PMID:7489725
Molecular Function	GO:0005515	protein binding	Fxr1	IPI	UniProtKB:Q5SQX6	Mouse	MGI:MGI:3036554|PMID:11438699
Molecular Function	GO:0005515	protein binding	Fxr1	IPI	UniProtKB:P35922	Mouse	MGI:MGI:5767076|PMID:10567518
Molecular Function	GO:0046982	protein heterodimerization activity	FXR1	IDA		Human	PMID:7489725
Molecular Function	GO:0042803	protein homodimerization activity	FXR1	IDA		Human	PMID:7489725
Molecular Function	GO:0003723	RNA binding	FXR1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	FXR1	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	FXR1	IDA		Human	PMID:35989368
Molecular Function	GO:0033592	RNA strand annealing activity	FXR1	IDA		Human	PMID:17057366
Molecular Function	GO:0045182	translation regulator activity	FXR1	IDA		Human	PMID:34731628
Molecular Function	GO:0045182	translation regulator activity	Fxr1	IDA		Mouse	PMID:35951695
Cellular Component	GO:0030424	axon	Fxr1	IDA		Mouse	PMID:22022532
Cellular Component	GO:0043034	costamere	Fxr1	IDA		Mouse	PMID:15128702
Cellular Component	GO:0005737	cytoplasm	FXR1	IDA		Human	PMID:9259278
Cellular Component	GO:0005737	cytoplasm	FXR1	IMP		Human	PMID:30770808
Cellular Component	GO:0005737	cytoplasm	Fxr1	IDA		Mouse	PMID:35951695
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	FXR1	IDA		Human	PMID:32706158
Cellular Component	GO:0010494	cytoplasmic stress granule	FXR1	IDA		Human	PMID:12417522
Cellular Component	GO:0010494	cytoplasmic stress granule	FXR1	IDA		Human	PMID:20417602
Cellular Component	GO:0005829	cytosol	FXR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	FXR1	IDA		Human	PMID:30770808
Cellular Component	GO:0005829	cytosol	Fxr1	IDA		Mouse	MGI:MGI:6287080|PMID:30770808
Cellular Component	GO:0030425	dendrite	Fxr1	IDA		Mouse	PMID:22022532
Cellular Component	GO:0043197	dendritic spine	Fxr1	IDA		Mouse	PMID:22022532
Cellular Component	GO:0098978	glutamatergic synapse	Fxr1	IDA		Mouse	PMID:27770568
Cellular Component	GO:0043232	intracellular non-membrane-bounded organelle	Fxr1	IDA		Mouse	PMID:35951695
Cellular Component	GO:0016020	membrane	FXR1	HDA		Human	PMID:19946888
Cellular Component	GO:0005635	nuclear envelope	FXR1	IDA		Human	PMID:32706158
Cellular Component	GO:0005634	nucleus	Fxr1	IDA		Mouse	PMID:11178106
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Fxr1	IDA		Mouse	PMID:22022532
Cellular Component	GO:0005844	polysome	Fxr1	IDA		Mouse	PMID:22022532
Cellular Component	GO:0098794	postsynapse	Fxr1	IDA		Mouse	PMID:27770568
Cellular Component	GO:0035770	ribonucleoprotein granule	Fxr1	IDA		Mouse	PMID:22022532
Biological Process	GO:0021542	dentate gyrus development	Fxr1	IMP		Mouse	MGI:MGI:5904238|PMID:28204491
Biological Process	GO:0007507	heart development	fxr1	IMP	ZFIN:ZDB-MRPHLNO-100105-1	Zfish	PMID:19648401
Biological Process	GO:0007507	heart development	fxr1	IMP	ZFIN:ZDB-MRPHLNO-100105-2	Zfish	PMID:19648401
Biological Process	GO:0061157	mRNA destabilization	FXR1	IDA		Human	PMID:30067974
Biological Process	GO:0055001	muscle cell development	fxr1	IMP	ZFIN:ZDB-MRPHLNO-100722-1	Zfish	PMID:20417602
Biological Process	GO:0007517	muscle organ development	FXR1	IMP		Human	PMID:30770808
Biological Process	GO:0007517	muscle organ development	Fxr1	IDA		Mouse	MGI:MGI:6446543|PMID:32328638
Biological Process	GO:0007517	muscle organ development	Fxr1	IMP		Mouse	MGI:MGI:6287080|PMID:30770808
Biological Process	GO:0007517	muscle organ development	Fxr1	IMP	MGI:MGI:3046846	Mouse	PMID:15128702
Biological Process	GO:0050728	negative regulation of inflammatory response	FXR1	IDA		Human	PMID:30067974
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	Fxr1	IMP		Mouse	MGI:MGI:5618352|PMID:25456134
Biological Process	GO:0017148	negative regulation of translation	Fxr1	IDA		Mouse	MGI:MGI:5618352|PMID:25456134
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Fxr1	IDA		Mouse	MGI:MGI:3573966|PMID:15548538
Biological Process	GO:0140694	non-membrane-bounded organelle assembly	Fxr1	IDA		Mouse	PMID:35951695
Biological Process	GO:0051292	nuclear pore complex assembly	FXR1	IDA		Human	PMID:32706158
Biological Process	GO:0051664	nuclear pore localization	FXR1	IDA		Human	PMID:32706158
Biological Process	GO:2000637	positive regulation of miRNA-mediated gene silencing	FXR1	IDA		Human	PMID:17057366
Biological Process	GO:0045727	positive regulation of translation	FXR1	IDA		Human	PMID:17382880
Biological Process	GO:0045727	positive regulation of translation	FXR1	IDA		Human	PMID:34731628
Biological Process	GO:0045727	positive regulation of translation	FXR1	IDA		Human	PMID:36306353
Biological Process	GO:0045727	positive regulation of translation	Fxr1	IDA		Mouse	PMID:35951695
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	Fxr1	IMP		Mouse	MGI:MGI:6706222|PMID:32893934
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	Fxr1	IDA		Mouse	MGI:MGI:3573966|PMID:15548538
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	Fxr1	IMP		Mouse	MGI:MGI:6706222|PMID:32893934
Biological Process	GO:0050767	regulation of neurogenesis	Fxr1	IDA		Mouse	MGI:MGI:5904238|PMID:28204491
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Fxr1	IMP		Mouse	MGI:MGI:5618352|PMID:25456134
Biological Process	GO:0060538	skeletal muscle organ development	FXR1	IMP		Human	PMID:30770808
Biological Process	GO:0060538	skeletal muscle organ development	Fxr1	IDA		Mouse	MGI:MGI:6287080|PMID:30770808
Biological Process	GO:0007519	skeletal muscle tissue development	fxr1	IMP	ZFIN:ZDB-MRPHLNO-100105-2	Zfish	PMID:19648401
Biological Process	GO:0007519	skeletal muscle tissue development	fxr1	IMP	ZFIN:ZDB-MRPHLNO-100105-1	Zfish	PMID:19648401
Biological Process	GO:0001756	somitogenesis	fxr1	IMP	ZFIN:ZDB-MRPHLNO-100722-1	Zfish	PMID:20417602
Biological Process	GO:0007286	spermatid development	Fxr1	IDA		Mouse	PMID:35951695

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern