Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Fzd1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FZD1
- Mouse genes Fzd1
- Rat genes Fzd1
- Zfish genes fzd1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fzd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	FZD1	IPI	UniProtKB:Q99972	Human	PMID:19188438
Molecular Function	GO:0042802	identical protein binding	Fzd1	IPI	UniProtKB:Q08463	Rat	PMID:14688793\|RGD:8553956
Molecular Function	GO:0030165	PDZ domain binding	FZD1	IPI	UniProtKB:O14640	Human	PMID:19388021
Molecular Function	GO:0030165	PDZ domain binding	FZD1	IPI	UniProtKB:O14641	Human	PMID:19388021
Molecular Function	GO:0030165	PDZ domain binding	FZD1	IPI	UniProtKB:Q92997	Human	PMID:19388021
Molecular Function	GO:0005515	protein binding	FZD1	IPI	UniProtKB:Q8N474	Human	PMID:19277043
Molecular Function	GO:0005515	protein binding	FZD1	IPI	UniProtKB:P18177:PRO_0000072636	Human	PMID:27680706
Molecular Function	GO:0005515	protein binding	Fzd1	IPI	UniProtKB:Q08464	Rat	PMID:14688793\|RGD:8553956
Molecular Function	GO:0046982	protein heterodimerization activity	Fzd1	IPI	UniProtKB:Q08464	Rat	PMID:14688793\|RGD:8553956
Molecular Function	GO:0042803	protein homodimerization activity	Fzd1	IPI	UniProtKB:Q08463	Rat	PMID:14688793\|RGD:8553956
Molecular Function	GO:0005102	signaling receptor binding	FZD1	IPI	UniProtKB:O75581	Human	PMID:14739301
Molecular Function	GO:0042813	Wnt receptor activity	FZD1	IDA		Human	PMID:10557084
Molecular Function	GO:0042813	Wnt receptor activity	FZD1	IDA		Human	PMID:28733458
Molecular Function	GO:0017147	Wnt-protein binding	FZD1	IPI	UniProtKB:P09544	Human	PMID:10557084
Molecular Function	GO:0017147	Wnt-protein binding	FZD1	IPI	UniProtKB:P22725	Human	PMID:10557084
Molecular Function	GO:0017147	Wnt-protein binding	FZD1	IPI	UniProtKB:P56703	Human	PMID:10557084
Molecular Function	GO:0017147	Wnt-protein binding	Fzd1	IPI	PR:P28047	Mouse	PMID:15923619
Cellular Component	GO:0009986	cell surface	FZD1	IDA		Human	PMID:19643732
Cellular Component	GO:0005925	focal adhesion	FZD1	HDA		Human	PMID:21423176
Cellular Component	GO:0043005	neuron projection	Fzd1	IDA		Rat	PMID:19883499\|RGD:4107041
Cellular Component	GO:0005886	plasma membrane	Fzd1	IDA		Rat	PMID:14688793\|RGD:8553956
Biological Process	GO:0036520	astrocyte-dopaminergic neuron signaling	Fzd1	IMP		Mouse	MGI:MGI:5770063\|PMID:21752258
Biological Process	GO:0035425	autocrine signaling	FZD1	IDA		Human	PMID:10557084
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD1	IDA		Human	PMID:10557084
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD1	IGI	UniProtKB:P27467	Human	PMID:11433302
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD1	IDA		Human	PMID:14739301
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD1	IDA		Human	PMID:28733458
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd1	IMP		Mouse	MGI:MGI:5770063\|PMID:21752258
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd1	IGI	MGI:MGI:2136761	Mouse	PMID:15923619
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd1	IMP		Mouse	PMID:15143170
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd1	IGI	MGI:MGI:98961	Mouse	PMID:15923619
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd1	IGI	MGI:MGI:1278315	Mouse	PMID:15923619
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd1	IDA		Rat	PMID:14688793\|RGD:8553956
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd1	IDA		Rat	PMID:18945944\|RGD:8554426
Biological Process	GO:0044338	canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	FZD1	IMP		Human	PMID:20039315
Biological Process	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation	FZD1	IMP		Human	PMID:20039315
Biological Process	GO:0007267	cell-cell signaling	FZD1	IDA		Human	PMID:10557084
Biological Process	GO:0007267	cell-cell signaling	Fzd1	IDA		Mouse	PMID:15809042
Biological Process	GO:0071363	cellular response to growth factor stimulus	Fzd1	IEP		Rat	PMID:1334084\|RGD:61590
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Fzd1	IEP		Rat	PMID:1334084\|RGD:61590
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Fzd1	IEP		Rat	PMID:15962290\|RGD:2298726
Biological Process	GO:0071305	cellular response to vitamin D	Fzd1	IEP		Rat	PMID:1334084\|RGD:61590
Biological Process	GO:0045446	endothelial cell differentiation	Fzd1	IGI	MGI:MGI:103124	Mouse	PMID:15809042
Biological Process	GO:0045446	endothelial cell differentiation	Fzd1	IDA		Mouse	PMID:15809042
Biological Process	GO:0060022	hard palate development	Fzd1	IGI	MGI:MGI:1888513	Mouse	PMID:20940229
Biological Process	GO:0048286	lung alveolus development	Fzd1	IEP		Rat	PMID:17911382\|RGD:2304247
Biological Process	GO:0003149	membranous septum morphogenesis	Fzd1	IGI	MGI:MGI:1888513	Mouse	PMID:20940229
Biological Process	GO:0003149	membranous septum morphogenesis	Fzd1	IGI	MGI:MGI:2135272	Mouse	PMID:20940229
Biological Process	GO:0003150	muscular septum morphogenesis	Fzd1	IGI	MGI:MGI:2135272	Mouse	PMID:20940229
Biological Process	GO:0003150	muscular septum morphogenesis	Fzd1	IGI	MGI:MGI:1888513	Mouse	PMID:20940229
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Fzd1	IDA		Mouse	PMID:14627707
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Fzd1	IDA		Mouse	PMID:14627707
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Fzd1	IMP		Mouse	PMID:16936075
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	Fzd1	IMP		Mouse	MGI:MGI:5770063\|PMID:21752258
Biological Process	GO:0003151	outflow tract morphogenesis	Fzd1	IGI	MGI:MGI:1888513	Mouse	PMID:20940229
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Fzd1	IGI	MGI:MGI:1888513	Mouse	PMID:20940229
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Fzd1	IGI	MGI:MGI:2135272	Mouse	PMID:20940229
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	FZD1	IDA		Human	PMID:10557084
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	FZD1	IDA		Human	PMID:14739301
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Fzd1	IDA		Rat	PMID:14688793\|RGD:8553956
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Fzd1	IDA		Rat	PMID:18945944\|RGD:8554426
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FZD1	IDA		Human	PMID:18929644
Biological Process	GO:0010976	positive regulation of neuron projection development	Fzd1	IDA		Rat	PMID:23825416\|RGD:8655547
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Fzd1	IMP		Mouse	PMID:15143170
Biological Process	GO:0045667	regulation of osteoblast differentiation	Fzd1	IEP		Rat	PMID:1334084\|RGD:61590
Biological Process	GO:1905606	regulation of presynapse assembly	Fzd1	IDA		Mouse	PMID:19883499
Biological Process	GO:1905606	regulation of presynapse assembly	Fzd1	IMP		Mouse	PMID:19883499
Biological Process	GO:0009410	response to xenobiotic stimulus	FZD1	IMP		Human	PMID:19421142
Biological Process	GO:0060412	ventricular septum morphogenesis	Fzd1	IGI	MGI:MGI:1888513	Mouse	PMID:20940229
Biological Process	GO:0016055	Wnt signaling pathway	Fzd1	IDA		Rat	PMID:10559239\|RGD:4107043

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.