Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FZD2
  • Mouse genes Fzd2
  • Rat genes Fzd2
  • Zfish genes fzd2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fzd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Fzd2	IPI	UniProtKB:Q08464	Rat	PMID:14688793|RGD:8553956
Molecular Function	GO:0030165	PDZ domain binding	FZD2	IPI	UniProtKB:O14640	Human	PMID:19388021
Molecular Function	GO:0030165	PDZ domain binding	FZD2	IPI	UniProtKB:O14641	Human	PMID:19388021
Molecular Function	GO:0030165	PDZ domain binding	FZD2	IPI	UniProtKB:Q92997	Human	PMID:19388021
Molecular Function	GO:0005515	protein binding	FZD2	IPI	UniProtKB:P39688	Human	PMID:25417160
Molecular Function	GO:0005515	protein binding	FZD2	IPI	UniProtKB:P18177:PRO_0000072636	Human	PMID:27680706
Molecular Function	GO:0005515	protein binding	FZD2	IPI	UniProtKB:M4NKV9	Human	PMID:29748286
Molecular Function	GO:0005515	protein binding	FZD2	IPI	UniProtKB:P18177:PRO_0000072636	Human	PMID:29748286
Molecular Function	GO:0005515	protein binding	Fzd2	IPI	PR:Q9R0Q3	Mouse	PMID:35353806
Molecular Function	GO:0005515	protein binding	Fzd2	IPI	PR:Q9Z138	Mouse	PMID:12839624
Molecular Function	GO:0005515	protein binding	Fzd2	IPI	UniProtKB:Q08463	Rat	PMID:14688793|RGD:8553956
Molecular Function	GO:0046982	protein heterodimerization activity	Fzd2	IPI	UniProtKB:Q08463	Rat	PMID:14688793|RGD:8553956
Molecular Function	GO:0042813	Wnt receptor activity	FZD2	IDA		Human	PMID:28733458
Molecular Function	GO:0042813	Wnt receptor activity	Fzd2	IDA		Mouse	PMID:10893270
Molecular Function	GO:0042813	Wnt receptor activity	Fzd2	IDA		Rat	PMID:12471263|RGD:727481
Cellular Component	GO:0005737	cytoplasm	FZD2	IDA		Human	PMID:19038973
Cellular Component	GO:0005925	focal adhesion	FZD2	HDA		Human	PMID:21423176
Cellular Component	GO:0005886	plasma membrane	FZD2	IDA		Human	PMID:18929644
Cellular Component	GO:0005886	plasma membrane	Fzd2	IDA		Rat	PMID:14688793|RGD:8553956
Cellular Component	GO:0005886	plasma membrane	fzd2	IDA		Zfish	PMID:20660632
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD2	IDA		Human	PMID:18215320
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD2	IDA		Human	PMID:18929644
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD2	IDA		Human	PMID:20802536
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD2	IDA		Human	PMID:28733458
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd2	IDA		Rat	PMID:24080158|RGD:10448946
Biological Process	GO:0001775	cell activation	Fzd2	IEP		Rat	PMID:16780995|RGD:2317900
Biological Process	GO:0016477	cell migration	fzd2	IMP	ZFIN:ZDB-MRPHLNO-051207-2,ZFIN:ZDB-MRPHLNO-051207-3	Zfish	PMID:16246260
Biological Process	GO:0007267	cell-cell signaling	Fzd2	IDA		Mouse	PMID:15809042
Biological Process	GO:0071363	cellular response to growth factor stimulus	Fzd2	IEP		Rat	PMID:1334084|RGD:61590
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Fzd2	IEP		Rat	PMID:1334084|RGD:61590
Biological Process	GO:0071305	cellular response to vitamin D	Fzd2	IEP		Rat	PMID:1334084|RGD:61590
Biological Process	GO:0060271	cilium assembly	fzd2	IMP	ZFIN:ZDB-MRPHLNO-051207-2,ZFIN:ZDB-MRPHLNO-051207-3	Zfish	PMID:17013396
Biological Process	GO:0090103	cochlea morphogenesis	Fzd2	IGI	MGI:MGI:2135272	Mouse	PMID:20940229
Biological Process	GO:0060027	convergent extension involved in gastrulation	fzd2	IMP	ZFIN:ZDB-MRPHLNO-051207-2,ZFIN:ZDB-MRPHLNO-051207-3	Zfish	PMID:12676324
Biological Process	GO:0060027	convergent extension involved in gastrulation	fzd2	IMP	ZFIN:ZDB-MRPHLNO-051207-2,ZFIN:ZDB-MRPHLNO-051207-3	Zfish	PMID:11477686
Biological Process	GO:0007368	determination of left/right symmetry	fzd2	IGI	ZFIN:ZDB-MRPHLNO-051207-2,ZFIN:ZDB-MRPHLNO-051207-3,ZFIN:ZDB-MRPHLNO-061207-1	Zfish	PMID:17013396
Biological Process	GO:0007368	determination of left/right symmetry	fzd2	IMP	ZFIN:ZDB-MRPHLNO-051207-2,ZFIN:ZDB-MRPHLNO-051207-3	Zfish	PMID:17013396
Biological Process	GO:0031018	endocrine pancreas development	fzd2	IMP	ZFIN:ZDB-MRPHLNO-051207-2,ZFIN:ZDB-MRPHLNO-051207-3	Zfish	PMID:16246260
Biological Process	GO:0045446	endothelial cell differentiation	Fzd2	IDA		Mouse	PMID:15809042
Biological Process	GO:0045446	endothelial cell differentiation	Fzd2	IGI	MGI:MGI:103124	Mouse	PMID:15809042
Biological Process	GO:0007199	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	Fzd2	IDA		Rat	PMID:12471263|RGD:727481
Biological Process	GO:0060022	hard palate development	Fzd2	IGI	MGI:MGI:1196625	Mouse	PMID:20940229
Biological Process	GO:0060022	hard palate development	Fzd2	IMP	MGI:MGI:4442611	Mouse	PMID:20940229
Biological Process	GO:0003146	heart jogging	fzd2	IMP		Zfish	PMID:17013396
Biological Process	GO:0001947	heart looping	fzd2	IMP		Zfish	PMID:17013396
Biological Process	GO:0060119	inner ear receptor cell development	Fzd2	IGI	MGI:MGI:2135272	Mouse	PMID:20940229
Biological Process	GO:0003149	membranous septum morphogenesis	Fzd2	IGI	MGI:MGI:1196625	Mouse	PMID:20940229
Biological Process	GO:0003149	membranous septum morphogenesis	Fzd2	IGI	MGI:MGI:2135272	Mouse	PMID:20940229
Biological Process	GO:0003150	muscular septum morphogenesis	Fzd2	IGI	MGI:MGI:1196625	Mouse	PMID:20940229
Biological Process	GO:0003150	muscular septum morphogenesis	Fzd2	IGI	MGI:MGI:2135272	Mouse	PMID:20940229
Biological Process	GO:0061341	non-canonical Wnt signaling pathway involved in heart development	fzd2	IMP		Zfish	PMID:17013396
Biological Process	GO:0003151	outflow tract morphogenesis	Fzd2	IGI	MGI:MGI:1196625	Mouse	PMID:20940229
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Fzd2	IGI	MGI:MGI:1196625	Mouse	PMID:20940229
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Fzd2	IGI	MGI:MGI:2135272	Mouse	PMID:20940229
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Fzd2	IDA		Rat	PMID:12471263|RGD:727481
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	FZD2	IDA		Human	PMID:18929644
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FZD2	IDA		Human	PMID:18215320
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FZD2	IDA		Human	PMID:18929644
Biological Process	GO:0070654	sensory epithelium regeneration	fzd2	IEP		Zfish	PMID:21911394
Biological Process	GO:0007608	sensory perception of smell	Fzd2	IMP	MGI:MGI:4442611	Mouse	PMID:20940229
Biological Process	GO:0060412	ventricular septum morphogenesis	Fzd2	IGI	MGI:MGI:1196625	Mouse	PMID:20940229
Biological Process	GO:0016055	Wnt signaling pathway	FZD2	IMP		Human	PMID:29276006
Biological Process	GO:0007223	Wnt signaling pathway, calcium modulating pathway	Fzd2	IDA		Rat	PMID:12471263|RGD:727481
Biological Process	GO:0007223	Wnt signaling pathway, calcium modulating pathway	fzd2	IGI	ZFIN:ZDB-MRPHLNO-051207-1,ZFIN:ZDB-MRPHLNO-051207-2,ZFIN:ZDB-MRPHLNO-051207-3	Zfish	PMID:16246260

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern