Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FZD4
  • Mouse genes Fzd4
  • Rat genes Fzd4
  • Zfish genes fzd4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fzd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	FZD4	IPI	CHEBI:64646	Human	PMID:18234671
Molecular Function	GO:0001540	amyloid-beta binding	FZD4	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:18234671
Molecular Function	GO:0001540	amyloid-beta binding	FZD4	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:18234671
Molecular Function	GO:0019955	cytokine binding	FZD4	IPI	UniProtKB:Q00604	Human	PMID:17955262
Molecular Function	GO:0019955	cytokine binding	Fzd4	IPI	UniProtKB:P48744	Mouse	MGI:MGI:3621833|PMID:15035989
Molecular Function	GO:0004896	cytokine receptor activity	FZD4	IDA		Human	PMID:17955262
Molecular Function	GO:0030165	PDZ domain binding	FZD4	IPI	UniProtKB:O14640	Human	PMID:19388021
Molecular Function	GO:0030165	PDZ domain binding	FZD4	IPI	UniProtKB:O14641	Human	PMID:19388021
Molecular Function	GO:0030165	PDZ domain binding	FZD4	IPI	UniProtKB:Q92997	Human	PMID:19388021
Molecular Function	GO:0030165	PDZ domain binding	FZD4	IDA		Human	PMID:20802536
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:Q00604	Human	PMID:17955262
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:Q8N474	Human	PMID:19277043
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:Q00604	Human	PMID:19837033
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:G3GTH2	Human	PMID:20802536
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:Q60838	Human	PMID:20802536
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:P01023	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FZD4	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Fzd4	IPI	UniProtKB:P0CG48	Mouse	MGI:MGI:5508739|PMID:20495530
Molecular Function	GO:0005515	protein binding	Fzd4	IPI	UniProtKB:P31016	Mouse	MGI:MGI:6114830|PMID:25424568
Molecular Function	GO:0005515	protein binding	Fzd4	IPI	UniProtKB:O19116	Mouse	PMID:18156211
Molecular Function	GO:0005515	protein binding	Fzd4	IPI	PR:Q8CBR6	Mouse	PMID:21856951
Molecular Function	GO:0005515	protein binding	Fzd4	IPI	PR:Q9EQJ9	Mouse	PMID:15195140
Molecular Function	GO:0005515	protein binding	Fzd4	IPI	PR:P28047	Mouse	PMID:15923619
Molecular Function	GO:0005515	protein binding	Fzd4	IPI	PR:O70283	Mouse	PMID:21856951
Molecular Function	GO:0046982	protein heterodimerization activity	FZD4	IPI	UniProtKB:O00144	Human	PMID:14688793
Molecular Function	GO:0042803	protein homodimerization activity	FZD4	IPI	UniProtKB:Q9ULV1	Human	PMID:14688793
Molecular Function	GO:0044877	protein-containing complex binding	FZD4	IPI	ComplexPortal:CPX-1134	Human	PMID:18234671
Molecular Function	GO:0038023	signaling receptor activity	Fzd4	IGI	UniProtKB:Q9QZH0	Mouse	MGI:MGI:6114830|PMID:25424568
Molecular Function	GO:0038023	signaling receptor activity	Fzd4	IGI	UniProtKB:Q61088	Rat	PMID:25424568|RGD:11060597
Molecular Function	GO:0031625	ubiquitin protein ligase binding	FZD4	IPI	UniProtKB:Q9ULT6	Human	PMID:22575959
Molecular Function	GO:0042813	Wnt receptor activity	FZD4	IDA		Human	PMID:28733458
Molecular Function	GO:0042813	Wnt receptor activity	Fzd4	IPI	PR:P28047	Mouse	PMID:16163358
Molecular Function	GO:0017147	Wnt-protein binding	Fzd4	IPI	UniProtKB:Q98SN7	Mouse	MGI:MGI:4821080|PMID:12490564
Molecular Function	GO:0017147	Wnt-protein binding	Fzd4	IPI	RGD:736431	Rat	PMID:18302287|RGD:2298703
Cellular Component	GO:0009986	cell surface	FZD4	IDA		Human	PMID:19643732
Cellular Component	GO:0005911	cell-cell junction	Fzd4	IDA		Mouse	PMID:15195140
Cellular Component	GO:0030425	dendrite	Fzd4	IMP		Mouse	MGI:MGI:6114830|PMID:25424568
Cellular Component	GO:0098978	glutamatergic synapse	Fzd4	IDA		Mouse	PMID:16501258
Cellular Component	GO:0005886	plasma membrane	FZD4	IDA		Human	PMID:12172548
Cellular Component	GO:0005886	plasma membrane	FZD4	IDA		Human	PMID:14688793
Cellular Component	GO:0005886	plasma membrane	FZD4	IDA		Human	PMID:15035989
Cellular Component	GO:0005886	plasma membrane	FZD4	IDA		Human	PMID:30135577
Cellular Component	GO:0005886	plasma membrane	Fzd4	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Cellular Component	GO:0005886	plasma membrane	Fzd4	IMP		Mouse	MGI:MGI:3772546|PMID:18156211
Cellular Component	GO:0005886	plasma membrane	Fzd4	IDA		Mouse	PMID:18156211
Cellular Component	GO:0045202	synapse	Fzd4	IDA		Mouse	PMID:16501258
Biological Process	GO:0001525	angiogenesis	Fzd4	IGI	MGI:MGI:102570	Mouse	PMID:27823583
Biological Process	GO:0001525	angiogenesis	Fzd4	IMP	MGI:MGI:4412057	Mouse	PMID:27823583
Biological Process	GO:0001568	blood vessel development	Fzd4	IMP	MGI:MGI:4412057	Mouse	PMID:19837032
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD4	IDA		Human	PMID:14688793
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD4	IDA		Human	PMID:20802536
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD4	IDA		Human	PMID:28733458
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd4	IGI	UniProtKB:P27467	Mouse	MGI:MGI:5700300|PMID:19001373
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd4	IGI	MGI:MGI:98962	Mouse	PMID:16163358
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd4	IGI	MGI:MGI:98956	Mouse	PMID:16115200
Biological Process	GO:0008283	cell population proliferation	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:25414188
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Fzd4	IEP		Mouse	PMID:20439489
Biological Process	GO:0061301	cerebellum vasculature morphogenesis	Fzd4	IMP		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0045446	endothelial cell differentiation	Fzd4	IMP		Mouse	PMID:23217714
Biological Process	GO:0060856	establishment of blood-brain barrier	Fzd4	IMP		Mouse	PMID:23217714
Biological Process	GO:0060856	establishment of blood-brain barrier	Fzd4	IGI	MGI:MGI:98961	Mouse	PMID:30478038
Biological Process	GO:0035426	extracellular matrix-cell signaling	Fzd4	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0031987	locomotion involved in locomotory behavior	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:11425903
Biological Process	GO:0001553	luteinization	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:16093361
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	FZD4	IMP		Human	PMID:18156211
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	Fzd4	IMP		Mouse	MGI:MGI:3772546|PMID:18156211
Biological Process	GO:0110135	Norrin signaling pathway	FZD4	IDA		Human	PMID:15035989
Biological Process	GO:0110135	Norrin signaling pathway	FZD4	IDA		Human	PMID:17955262
Biological Process	GO:0110135	Norrin signaling pathway	Fzd4	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0030335	positive regulation of cell migration	FZD4	IMP		Human	PMID:22057916
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Fzd4	IMP		Rat	PMID:25424568|RGD:11060597
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	FZD4	IDA		Human	PMID:14688793
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Fzd4	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FZD4	IDA		Human	PMID:15035989
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FZD4	IDA		Human	PMID:17955262
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Fzd4	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Fzd4	IGI	MGI:MGI:1923484	Mouse	PMID:15195140
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Fzd4	IGI	MGI:MGI:2135272	Mouse	PMID:15195140
Biological Process	GO:0150012	positive regulation of neuron projection arborization	Fzd4	IGI	UniProtKB:Q9QZH0	Mouse	MGI:MGI:6114830|PMID:25424568
Biological Process	GO:0150012	positive regulation of neuron projection arborization	Fzd4	IGI	UniProtKB:Q61088	Rat	PMID:25424568|RGD:11060597
Biological Process	GO:0042701	progesterone secretion	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:16093361
Biological Process	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:16093361
Biological Process	GO:0001666	response to hypoxia	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:25414188
Biological Process	GO:0001895	retina homeostasis	fzd4	IMP	ZFIN:ZDB-GENO-220113-1	Zfish	PMID:31566834
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Fzd4	IMP		Mouse	PMID:23217714
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:25083995
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:25414188
Biological Process	GO:0061298	retina vasculature development in camera-type eye	fzd4	IMP	ZFIN:ZDB-GENO-220113-1	Zfish	PMID:31566834
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	FZD4	IMP		Human	PMID:12172548
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	FZD4	IMP		Human	PMID:15024691
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Fzd4	IMP	MGI:MGI:4412057	Mouse	PMID:19837032
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Fzd4	IGI	MGI:MGI:102570	Mouse	PMID:19837032
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Fzd4	IGI	MGI:MGI:1278315	Mouse	PMID:19837032
Biological Process	GO:0061304	retinal blood vessel morphogenesis	Fzd4	IMP		Mouse	MGI:MGI:3621833|PMID:15035989
Biological Process	GO:0007605	sensory perception of sound	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:11425903
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	Fzd4	IMP		Mouse	PMID:18156211
Biological Process	GO:0001570	vasculogenesis	Fzd4	IMP	MGI:MGI:2387667	Mouse	PMID:16093361
Biological Process	GO:0016055	Wnt signaling pathway	Fzd4	IGI	UniProtKB:Q9QZH0	Mouse	MGI:MGI:6114830|PMID:25424568
Biological Process	GO:0016055	Wnt signaling pathway	Fzd4	IGI	UniProtKB:Q61088	Rat	PMID:25424568|RGD:11060597
Biological Process	GO:0007223	Wnt signaling pathway, calcium modulating pathway	FZD4	IDA		Human	PMID:12172548

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern