Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Fzd5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FZD5
- Mouse genes Fzd5
- Rat genes Fzd5
- Zfish genes fzd5
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fzd5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	FZD5	IPI	CHEBI:64646	Human	PMID:18234671
Molecular Function	GO:0001540	amyloid-beta binding	FZD5	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:18234671
Molecular Function	GO:0001540	amyloid-beta binding	FZD5	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:18234671
Molecular Function	GO:0005515	protein binding	FZD5	IPI	UniProtKB:Q13145	Human	PMID:18838381
Molecular Function	GO:0005515	protein binding	FZD5	IPI	UniProtKB:Q6P3W7	Human	PMID:19643732
Molecular Function	GO:0005515	protein binding	FZD5	IPI	UniProtKB:Q68DV7	Human	PMID:22895187
Molecular Function	GO:0005515	protein binding	FZD5	IPI	UniProtKB:M4NKV9	Human	PMID:29748286
Molecular Function	GO:0005515	protein binding	FZD5	IPI	UniProtKB:P78383	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Fzd5	IPI	UniProtKB:Q8BH60	Mouse	MGI:MGI:3688061\|PMID:11520064
Molecular Function	GO:0005515	protein binding	Fzd5	IPI	PR:Q9D1D6	Mouse	PMID:18606138
Molecular Function	GO:0019901	protein kinase binding	FZD5	IPI	UniProtKB:Q6P3W7	Human	PMID:19643732
Molecular Function	GO:0044877	protein-containing complex binding	FZD5	IPI	ComplexPortal:CPX-1134	Human	PMID:18234671
Molecular Function	GO:0031625	ubiquitin protein ligase binding	FZD5	IPI	UniProtKB:Q9ULT6	Human	PMID:22575959
Molecular Function	GO:0042813	Wnt receptor activity	FZD5	IDA		Human	PMID:15459103
Molecular Function	GO:0042813	Wnt receptor activity	FZD5	IDA		Human	PMID:28733458
Molecular Function	GO:0042813	Wnt receptor activity	fzd5	IMP		Zfish	PMID:12676325
Molecular Function	GO:0017147	Wnt-protein binding	FZD5	IPI	UniProtKB:Q98SN7	Human	PMID:12490564
Molecular Function	GO:0017147	Wnt-protein binding	FZD5	IPI	UniProtKB:O00755	Human	PMID:12857724
Molecular Function	GO:0017147	Wnt-protein binding	FZD5	IPI	UniProtKB:P41221	Human	PMID:18174455
Molecular Function	GO:0017147	Wnt-protein binding	Fzd5	IPI	PR:P27467	Mouse	PMID:18606138
Molecular Function	GO:0017147	Wnt-protein binding	Fzd5	IPI	RGD:69079	Rat	PMID:18567805\|RGD:4107045
Cellular Component	GO:0005923	bicellular tight junction	Fzd5	IDA		Mouse	PMID:23610556
Cellular Component	GO:0009986	cell surface	FZD5	IDA		Human	PMID:19643732
Cellular Component	GO:0005769	early endosome	Fzd5	IDA		Mouse	MGI:MGI:5512849\|PMID:16890161
Cellular Component	GO:0098978	glutamatergic synapse	Fzd5	EXP		Rat	PMID:20530549\|RGD:13702329
Cellular Component	GO:0098978	glutamatergic synapse	Fzd5	IDA		Rat	PMID:20530549\|RGD:13702329
Cellular Component	GO:0098978	glutamatergic synapse	Fzd5	IMP		Rat	PMID:20530549\|RGD:13702329
Cellular Component	GO:0005794	Golgi apparatus	Fzd5	IDA		Mouse	MGI:MGI:3688061\|PMID:11520064
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Fzd5	IDA		Mouse	MGI:MGI:3688061\|PMID:11520064
Cellular Component	GO:0005886	plasma membrane	FZD5	IDA		Human	PMID:15459103
Cellular Component	GO:0005886	plasma membrane	Fzd5	IDA		Mouse	MGI:MGI:3688061\|PMID:11520064
Cellular Component	GO:0005886	plasma membrane	Fzd5	IDA		Mouse	MGI:MGI:5512849\|PMID:16890161
Cellular Component	GO:0045202	synapse	Fzd5	IDA		Rat	PMID:20530549\|RGD:13702329
Biological Process	GO:0001525	angiogenesis	Fzd5	IMP	MGI:MGI:2177951	Mouse	PMID:11092808
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	FZD5	IDA		Human	PMID:9054360
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	Fzd5	IMP	MGI:MGI:3574771,MGI:MGI:3583769	Mouse	PMID:18791178
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	Fzd5	IMP	MGI:MGI:3583769	Mouse	PMID:23610556
Biological Process	GO:0043010	camera-type eye development	fzd5	IMP	ZFIN:ZDB-MRPHLNO-160504-1	Zfish	PMID:26908622
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD5	IDA		Human	PMID:11029007
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD5	IDA		Human	PMID:12121999
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD5	IDA		Human	PMID:12857724
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD5	IDA		Human	PMID:15459103
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD5	IDA		Human	PMID:24080158
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD5	IDA		Human	PMID:28733458
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD5	IMP		Human	PMID:9054360
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd5	IMP		Mouse	PMID:11265645
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd5	IMP	MGI:MGI:3583769	Mouse	PMID:23610556
Biological Process	GO:0071219	cellular response to molecule of bacterial origin	FZD5	IDA		Human	PMID:16601243
Biological Process	GO:0060718	chorionic trophoblast cell differentiation	Fzd5	IMP	MGI:MGI:3583769	Mouse	PMID:23610556
Biological Process	GO:0000578	embryonic axis specification	FZD5	IDA		Human	PMID:12121999
Biological Process	GO:0031076	embryonic camera-type eye development	Fzd5	IMP	MGI:MGI:3574771,MGI:MGI:3583769	Mouse	PMID:18791178
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Fzd5	IMP		Mouse	MGI:MGI:3826935\|PMID:18832390
Biological Process	GO:0002071	glandular epithelial cell maturation	Fzd5	IMP		Mouse	PMID:15778706
Biological Process	GO:0060574	intestinal epithelial cell maturation	Fzd5	IMP		Mouse	PMID:15778706
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Fzd5	IMP	MGI:MGI:2177951	Mouse	PMID:11092808
Biological Process	GO:0001889	liver development	fzd5	IGI	ZFIN:ZDB-MRPHLNO-060705-6,ZFIN:ZDB-MRPHLNO-110916-6	Zfish	PMID:21771809
Biological Process	GO:0001889	liver development	fzd5	IGI	ZFIN:ZDB-GENO-110916-2,ZFIN:ZDB-MRPHLNO-060705-6	Zfish	PMID:21771809
Biological Process	GO:0001889	liver development	fzd5	IGI	ZFIN:ZDB-GENO-100709-5,ZFIN:ZDB-MRPHLNO-060705-6	Zfish	PMID:21771809
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	fzd5	IMP		Zfish	PMID:15996547
Biological Process	GO:0008285	negative regulation of cell population proliferation	Fzd5	IMP	MGI:MGI:3574771,MGI:MGI:3583769	Mouse	PMID:18791178
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	fzd5	IGI	ZFIN:ZDB-GENO-980202-1037,ZFIN:ZDB-MRPHLNO-060705-6	Zfish	PMID:15996547
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Fzd5	IGI	ComplexPortal:CPX-1134,UniProtKB:P22725	Mouse	MGI:MGI:5291547\|PMID:21857966
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Fzd5	IDA		Mouse	PMID:15195140
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	FZD5	HMP		Human	PMID:24912190
Biological Process	GO:0002726	positive regulation of T cell cytokine production	FZD5	IDA		Human	PMID:16601243
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FZD5	IGI	UniProtKB:P31286	Human	PMID:10906785
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FZD5	IDA		Human	PMID:12857724
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Fzd5	IMP	MGI:MGI:3583769	Mouse	PMID:23610556
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Fzd5	IGI	ComplexPortal:CPX-1134,UniProtKB:P22725	Mouse	MGI:MGI:5291547\|PMID:21857966
Biological Process	GO:0032729	positive regulation of type II interferon production	FZD5	IMP		Human	PMID:16601243
Biological Process	GO:0031077	post-embryonic camera-type eye development	Fzd5	IMP		Mouse	MGI:MGI:3826935\|PMID:18832390
Biological Process	GO:0031077	post-embryonic camera-type eye development	Fzd5	IMP	MGI:MGI:3574771,MGI:MGI:3583769	Mouse	PMID:18791178
Biological Process	GO:0099054	presynapse assembly	Fzd5	EXP		Rat	PMID:20530549\|RGD:13702329
Biological Process	GO:0099054	presynapse assembly	Fzd5	IDA		Rat	PMID:20530549\|RGD:13702329
Biological Process	GO:0099054	presynapse assembly	Fzd5	IMP		Rat	PMID:20530549\|RGD:13702329
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	FZD5	HMP		Human	PMID:24912190
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	Fzd5	IMP	MGI:MGI:3583769	Mouse	PMID:23610556
Biological Process	GO:1901382	regulation of chorionic trophoblast cell proliferation	Fzd5	IMP	MGI:MGI:3583769	Mouse	PMID:23610556
Biological Process	GO:0060061	Spemann organizer formation	FZD5	IDA		Human	PMID:9054360
Biological Process	GO:0048794	swim bladder development	fzd5	IMP	ZFIN:ZDB-MRPHLNO-060705-6	Zfish	PMID:21771809
Biological Process	GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development	Fzd5	IMP	MGI:MGI:3583769	Mouse	PMID:23610556
Biological Process	GO:0033077	T cell differentiation in thymus	Fzd5	IMP		Mouse	PMID:11265645
Biological Process	GO:0001944	vasculature development	Fzd5	IMP	MGI:MGI:3574771,MGI:MGI:3583769	Mouse	PMID:18791178
Biological Process	GO:0016055	Wnt signaling pathway	Fzd5	IGI	MGI:MGI:108061	Mouse	PMID:11092808
Biological Process	GO:0016055	Wnt signaling pathway	Fzd5	IGI	MGI:MGI:98958	Mouse	PMID:11092808
Biological Process	GO:0016055	Wnt signaling pathway	Fzd5	IGI	MGI:MGI:98954	Mouse	PMID:11092808
Biological Process	GO:0016055	Wnt signaling pathway	fzd5	IMP		Zfish	PMID:12676325

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.