Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FZD6
  • Mouse genes Fzd6
  • Rat genes Fzd6
  • Zfish genes fzd6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fzd6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	FZD6	IPI	UniProtKB:Q8N474	Human	PMID:10347172
Molecular Function	GO:0005515	protein binding	FZD6	IPI	UniProtKB:Q8N474	Human	PMID:1927703
Molecular Function	GO:0005515	protein binding	FZD6	IPI	UniProtKB:Q9ULT6	Human	PMID:22575959
Molecular Function	GO:0005515	protein binding	FZD6	IPI	UniProtKB:P47972	Human	PMID:30833544
Molecular Function	GO:0005515	protein binding	Fzd6	IPI	PR:Q9D1D6	Mouse	PMID:18606138
Molecular Function	GO:0031625	ubiquitin protein ligase binding	FZD6	IPI	UniProtKB:Q9ULT6	Human	PMID:22575959
Molecular Function	GO:0042813	Wnt receptor activity	FZD6	IDA		Human	PMID:10347172
Molecular Function	GO:0017147	Wnt-protein binding	Fzd6	IPI	UniProtKB:P22724	Mouse	MGI:MGI:4835152|PMID:15265686
Molecular Function	GO:0017147	Wnt-protein binding	Fzd6	IPI	PR:P27467	Mouse	PMID:18606138
Cellular Component	GO:0045177	apical part of cell	Fzd6	IDA		Mouse	PMID:16495441
Cellular Component	GO:0016324	apical plasma membrane	Fzd6	IDA		Mouse	PMID:25393619
Cellular Component	GO:0016327	apicolateral plasma membrane	Fzd6	IDA		Mouse	PMID:17376975
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Fzd6	IDA		Mouse	MGI:MGI:6303730|PMID:31073040
Cellular Component	GO:0005886	plasma membrane	FZD6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Fzd6	IDA		Mouse	MGI:MGI:6303730|PMID:31073040
Biological Process	GO:0001525	angiogenesis	fzd6	IMP	ZFIN:ZDB-MRPHLNO-091216-10,ZFIN:ZDB-MRPHLNO-091216-11	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	fzd6	IMP	ZFIN:ZDB-MRPHLNO-091216-10	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	fzd6	IMP	ZFIN:ZDB-MRPHLNO-091216-11	Zfish	PMID:19389629
Biological Process	GO:0033278	cell proliferation in midbrain	Fzd6	IGI	MGI:MGI:108476	Mouse	PMID:19842188
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	fzd6	IMP	ZFIN:ZDB-MRPHLNO-091216-11	Zfish	PMID:26436110
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	fzd6	IMP	ZFIN:ZDB-MRPHLNO-160119-7	Zfish	PMID:26436110
Biological Process	GO:0035880	embryonic nail plate morphogenesis	Fzd6	IMP	MGI:MGI:3050103	Mouse	PMID:23439395
Biological Process	GO:0048105	establishment of body hair planar orientation	Fzd6	IGI	MGI:MGI:1889277	Mouse	PMID:26418459
Biological Process	GO:0001736	establishment of planar polarity	Fzd6	IGI	MGI:MGI:108476	Mouse	PMID:16495441
Biological Process	GO:0001942	hair follicle development	Fzd6	IMP	MGI:MGI:3050103	Mouse	PMID:17172440
Biological Process	GO:0001942	hair follicle development	Fzd6	IMP	MGI:MGI:3050106	Mouse	PMID:15169958
Biological Process	GO:0042472	inner ear morphogenesis	Fzd6	IGI	MGI:MGI:108476	Mouse	PMID:16495441
Biological Process	GO:0030901	midbrain development	Fzd6	IGI	MGI:MGI:108476	Mouse	PMID:19842188
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	FZD6	IMP		Human	PMID:14747478
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	FZD6	IDA		Human	PMID:14747478
Biological Process	GO:0001843	neural tube closure	Fzd6	IGI	MGI:MGI:108476	Mouse	PMID:16495441
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	FZD6	IDA		Human	PMID:14747478
Biological Process	GO:0030168	platelet activation	Fzd6	IMP	MGI:MGI:3050103	Mouse	PMID:19901330
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Fzd6	IDA		Mouse	PMID:18606138

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern