Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FZD7
  • Mouse genes Fzd7
  • Rat genes Fzd7
  • Zfish genes fzd7a,fzd7b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fzd7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	FZD7	IPI	UniProtKB:Q99972	Human	PMID:19188438
Molecular Function	GO:0030165	PDZ domain binding	FZD7	IPI	UniProtKB:O00560	Human	PMID:18256285
Molecular Function	GO:0030165	PDZ domain binding	FZD7	IPI	UniProtKB:O14640	Human	PMID:19388021
Molecular Function	GO:0030165	PDZ domain binding	FZD7	IPI	UniProtKB:O14641	Human	PMID:19388021
Molecular Function	GO:0030165	PDZ domain binding	FZD7	IPI	UniProtKB:Q92997	Human	PMID:19388021
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	FZD7	IDA		Human	PMID:27386966
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q9UMX0	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:O00560	Human	PMID:18256285
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:P56703	Human	PMID:18313787
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:P56703	Human	PMID:21314951
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q9P219	Human	PMID:26126266
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:O00560	Human	PMID:27386966
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:P18177:PRO_0000072636	Human	PMID:27680706
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:P04156	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q9UMX0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:A8MZ59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:O14863	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:O15552	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:O43315	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:P10620	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:P37235	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:P61601	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:P62166	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q9BXK5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q9H2J7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q9NP94	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FZD7	IPI	UniProtKB:Q9UMX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Fzd7	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:5508283|PMID:12067714
Molecular Function	GO:0005515	protein binding	Fzd7	IPI	PR:Q9EQJ9	Mouse	PMID:15195140
Molecular Function	GO:0005515	protein binding	Fzd7	IPI	UniProtKB:O19116	Mouse	PMID:18156211
Molecular Function	GO:0042813	Wnt receptor activity	FZD7	IDA		Human	PMID:28733458
Molecular Function	GO:0042813	Wnt receptor activity	Fzd7	IMP		Mouse	PMID:19497282
Molecular Function	GO:0017147	Wnt-protein binding	FZD7	IPI	UniProtKB:P56703	Human	PMID:18313787
Molecular Function	GO:0017147	Wnt-protein binding	Fzd7	IPI	UniProtKB:P34383	Mouse	PMID:19497282
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	FZD7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FZD7	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005886	plasma membrane	FZD7	IDA		Human	PMID:18256285
Cellular Component	GO:0005886	plasma membrane	FZD7	IDA		Human	PMID:27386966
Cellular Component	GO:0005886	plasma membrane	Fzd7	IMP		Mouse	MGI:MGI:3772546|PMID:18156211
Cellular Component	GO:0005886	plasma membrane	Fzd7	IDA		Mouse	PMID:19497282
Cellular Component	GO:0005886	plasma membrane	Fzd7	IDA		Mouse	PMID:18156211
Cellular Component	GO:0005886	plasma membrane	fzd7a	IDA		Zfish	PMID:17130287
Cellular Component	GO:0055038	recycling endosome membrane	FZD7	IDA		Human	PMID:27386966
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD7	IDA		Human	PMID:18215320
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD7	IMP		Human	PMID:18313787
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD7	IMP		Human	PMID:19773752
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD7	IDA		Human	PMID:20802536
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD7	IDA		Human	PMID:28733458
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd7	IGI	UniProtKB:P27467	Mouse	MGI:MGI:5700300|PMID:19001373
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd7	IMP		Mouse	PMID:11265645
Biological Process	GO:0042074	cell migration involved in gastrulation	fzd7a	IMP	ZFIN:ZDB-MRPHLNO-050923-5	Zfish	PMID:16033799
Biological Process	GO:0035988	chondrocyte proliferation	fzd7a	IMP	ZFIN:ZDB-MRPHLNO-131025-2	Zfish	PMID:23806211
Biological Process	GO:0060027	convergent extension involved in gastrulation	fzd7a	IGI	ZFIN:ZDB-MRPHLNO-050923-5,ZFIN:ZDB-MRPHLNO-130219-1	Zfish	PMID:23349976
Biological Process	GO:0060027	convergent extension involved in gastrulation	fzd7b	IGI	ZFIN:ZDB-MRPHLNO-050923-5,ZFIN:ZDB-MRPHLNO-130219-1	Zfish	PMID:23349976
Biological Process	GO:0090504	epiboly	fzd7a	IGI	ZFIN:ZDB-MRPHLNO-050923-5,ZFIN:ZDB-MRPHLNO-120203-1,ZFIN:ZDB-MRPHLNO-130219-1	Zfish	PMID:23349976
Biological Process	GO:0090504	epiboly	fzd7b	IGI	ZFIN:ZDB-MRPHLNO-050923-5,ZFIN:ZDB-MRPHLNO-120203-1,ZFIN:ZDB-MRPHLNO-130219-1	Zfish	PMID:23349976
Biological Process	GO:0060231	mesenchymal to epithelial transition	FZD7	IMP		Human	PMID:17016432
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	FZD7	IGI	UniProtKB:Q8WU20	Human	PMID:23939491
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	FZD7	IMP		Human	PMID:18156211
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	Fzd7	IMP		Mouse	MGI:MGI:3772546|PMID:18156211
Biological Process	GO:0042666	negative regulation of ectodermal cell fate specification	FZD7	IMP		Human	PMID:18681827
Biological Process	GO:0048884	neuromast development	fzd7b	IGI	ZFIN:ZDB-GENO-200617-5	Zfish	PMID:31488837
Biological Process	GO:0048884	neuromast development	fzd7b	IGI	ZFIN:ZDB-GENE-990415-223	Zfish	PMID:31488837
Biological Process	GO:0048884	neuromast development	fzd7a	IGI	ZFIN:ZDB-GENO-200617-5	Zfish	PMID:31488837
Biological Process	GO:0048884	neuromast development	fzd7a	IGI	ZFIN:ZDB-GENE-990415-229	Zfish	PMID:31488837
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	Fzd7	IGI	MGI:MGI:98961	Mouse	PMID:19497282
Biological Process	GO:0038031	non-canonical Wnt signaling pathway via JNK cascade	FZD7	IMP		Human	PMID:19773752
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FZD7	IDA		Human	PMID:18215320
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FZD7	IMP		Human	PMID:19773752
Biological Process	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	FZD7	IMP		Human	PMID:18313787
Biological Process	GO:0042327	positive regulation of phosphorylation	FZD7	IDA		Human	PMID:18256285
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	FZD7	IMP		Human	PMID:9707618
Biological Process	GO:0006355	regulation of DNA-templated transcription	FZD7	IMP		Human	PMID:18681827
Biological Process	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	Fzd7	IMP		Mouse	PMID:19497282
Biological Process	GO:0048103	somatic stem cell division	Fzd7	IMP		Mouse	PMID:19497282
Biological Process	GO:0019827	stem cell population maintenance	FZD7	IMP		Human	PMID:18681827
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	Fzd7	IMP		Mouse	PMID:18156211
Biological Process	GO:0033077	T cell differentiation in thymus	Fzd7	IMP		Mouse	PMID:11265645

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern