Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FZD8
  • Mouse genes Fzd8
  • Rat genes Fzd8
  • Zfish genes fzd8a,fzd8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fzd8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030165	PDZ domain binding	FZD8	IPI	UniProtKB:O00560	Human	PMID:18256285
Molecular Function	GO:0030165	PDZ domain binding	Fzd8	IPI	UniProtKB:Q8BH60	Mouse	MGI:MGI:3688061|PMID:11520064
Molecular Function	GO:0005515	protein binding	FZD8	IPI	UniProtKB:P56704	Human	PMID:22682250
Molecular Function	GO:0005515	protein binding	FZD8	IPI	UniProtKB:P98086	Human	PMID:22682250
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	UniProtKB:O75581	Mouse	MGI:MGI:4839462|PMID:11029007
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	UniProtKB:P27467	Mouse	MGI:MGI:5918530|PMID:23791946
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	UniProtKB:Q8BH60	Mouse	MGI:MGI:3688061|PMID:11520064
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	UniProtKB:P27467|UniProtKB:P56703	Mouse	MGI:MGI:7327231|PMID:31036956
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	UniProtKB:O75581	Mouse	MGI:MGI:5532920|PMID:11448771
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	UniProtKB:O75581	Mouse	MGI:MGI:4835150|PMID:15908424
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	UniProtKB:P27467	Mouse	MGI:MGI:5424263|PMID:22575959
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	UniProtKB:P27467|UniProtKB:P47879	Mouse	MGI:MGI:3801389|PMID:18528331
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	UniProtKB:P28026	Mouse	MGI:MGI:5751673|PMID:22653731
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	PR:Q9Z132	Mouse	PMID:16543246
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	PR:Q01887	Mouse	PMID:15454084
Molecular Function	GO:0005515	protein binding	Fzd8	IPI	PR:Q2TJ95	Mouse	PMID:16543246
Molecular Function	GO:0005102	signaling receptor binding	Fzd8	IPI	UniProtKB:O75581	Mouse	MGI:MGI:4839462|PMID:11029007
Molecular Function	GO:0031625	ubiquitin protein ligase binding	FZD8	IPI	UniProtKB:Q9ULT6	Human	PMID:22575959
Molecular Function	GO:0042813	Wnt receptor activity	FZD8	IDA		Human	PMID:28733458
Molecular Function	GO:0042813	Wnt receptor activity	Fzd8	IPI	PR:P04426	Mouse	PMID:15454084
Molecular Function	GO:0017147	Wnt-protein binding	Fzd8	IPI	UniProtKB:P56704	Mouse	MGI:MGI:5706913|PMID:20093360
Molecular Function	GO:0017147	Wnt-protein binding	Fzd8	IPI	UniProtKB:P28026	Mouse	MGI:MGI:5700314|PMID:11357136
Molecular Function	GO:0017147	Wnt-protein binding	Fzd8	IPI	UniProtKB:P28026	Mouse	MGI:MGI:5751673|PMID:22653731
Molecular Function	GO:0017147	Wnt-protein binding	Fzd8	IPI	UniProtKB:O35468|UniProtKB:P22725|UniProtKB:P22726	Mouse	MGI:MGI:5706913|PMID:20093360
Molecular Function	GO:0017147	Wnt-protein binding	Fzd8	IPI	PR:P04426	Mouse	PMID:15454084
Cellular Component	GO:0098992	neuronal dense core vesicle	Fzd8	IDA		Mouse	PMID:21321602
Cellular Component	GO:0098992	neuronal dense core vesicle	Fzd8	EXP		Mouse	PMID:21321602
Cellular Component	GO:0005886	plasma membrane	Fzd8	IDA		Mouse	MGI:MGI:3621833|PMID:15035989
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	Fzd8	IPI	UniProtKB:O75581	Mouse	MGI:MGI:4839462|PMID:11029007
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	Fzd8	IPI	UniProtKB:O75581	Mouse	MGI:MGI:5532920|PMID:11448771
Cellular Component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	Fzd8	IDA		Mouse	MGI:MGI:5706913|PMID:20093360
Biological Process	GO:0001525	angiogenesis	Fzd8	IDA		Mouse	PMID:19129494
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD8	IMP		Human	PMID:22138402
Biological Process	GO:0060070	canonical Wnt signaling pathway	FZD8	IDA		Human	PMID:28733458
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd8	IGI	MGI:MGI:98956	Mouse	PMID:16115200
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd8	IDA		Mouse	PMID:16543246
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd8	IMP		Mouse	PMID:11265645
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd8	IMP		Mouse	PMID:15064719
Biological Process	GO:0060070	canonical Wnt signaling pathway	Fzd8	IMP		Mouse	PMID:15143170
Biological Process	GO:0060070	canonical Wnt signaling pathway	fzd8a	IGI	ZFIN:ZDB-MRPHLNO-060705-1,ZFIN:ZDB-MRPHLNO-060705-2	Zfish	PMID:15996547
Biological Process	GO:0009953	dorsal/ventral pattern formation	fzd8b	IGI	ZFIN:ZDB-GENE-980526-332	Zfish	PMID:9753682
Biological Process	GO:0009953	dorsal/ventral pattern formation	fzd8b	IMP		Zfish	PMID:9753682
Biological Process	GO:0009953	dorsal/ventral pattern formation	fzd8b	IDA		Zfish	PMID:9753682
Biological Process	GO:0060898	eye field cell fate commitment involved in camera-type eye formation	fzd8a	IGI	ZFIN:ZDB-MRPHLNO-060705-1,ZFIN:ZDB-MRPHLNO-060705-2	Zfish	PMID:15996547
Biological Process	GO:0021879	forebrain neuron differentiation	fzd8a	IMP	ZFIN:ZDB-MRPHLNO-060705-1	Zfish	PMID:18799544
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Fzd8	IDA		Mouse	PMID:15195140
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Fzd8	IMP		Mouse	PMID:15143170
Biological Process	GO:0021529	spinal cord oligodendrocyte cell differentiation	fzd8a	IMP	ZFIN:ZDB-MRPHLNO-060705-1	Zfish	PMID:18924237
Biological Process	GO:0021531	spinal cord radial glial cell differentiation	fzd8a	IMP	ZFIN:ZDB-MRPHLNO-060705-1	Zfish	PMID:18924237
Biological Process	GO:0033077	T cell differentiation in thymus	Fzd8	IMP		Mouse	PMID:11265645
Biological Process	GO:0016055	Wnt signaling pathway	Fzd8	IDA		Mouse	MGI:MGI:5700314|PMID:11357136
Biological Process	GO:0016055	Wnt signaling pathway	Fzd8	IDA		Mouse	PMID:19129494

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern