Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FZR1
  • Mouse genes Fzr1
  • Rat genes Fzr1
  • Zfish genes fzr1a,fzr1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fzr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019210	kinase inhibitor activity	FZR1	IDA		Human	PMID:14701726
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P30260	Human	PMID:10548110
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q9UI95	Human	PMID:11459826
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q9UKT4	Human	PMID:11988738
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q9UKT4	Human	PMID:16921029
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q9UI95	Human	PMID:17719540
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P30260	Human	PMID:18662541
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P53350	Human	PMID:18662541
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q9HAW4	Human	PMID:18662541
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:O75943	Human	PMID:20424596
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P40337	Human	PMID:20802534
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P40337-1	Human	PMID:20802534
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P40337-3	Human	PMID:20802534
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P30260	Human	PMID:21186364
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P30260	Human	PMID:21241890
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q86T82	Human	PMID:21596315
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P20794	Human	PMID:21986944
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P30260	Human	PMID:22014574
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q8IXJ6-2	Human	PMID:22014574
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P31350	Human	PMID:22632967
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q13309	Human	PMID:22770219
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q9UKT4	Human	PMID:23708001
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q9P2P5	Human	PMID:24163370
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:P41002	Human	PMID:27653696
Molecular Function	GO:0005515	protein binding	FZR1	IPI	UniProtKB:Q6UVJ0	Human	PMID:31722219
Molecular Function	GO:0005515	protein binding	Fzr1	IPI	UniProtKB:Q8VDQ8	Mouse	MGI:MGI:5295303|PMID:22014574
Molecular Function	GO:0005515	protein binding	Fzr1	IPI	PR:Q60665	Mouse	PMID:17215516
Molecular Function	GO:0005515	protein binding	Fzr1	IPI	UniProtKB:P61810	Rat	PMID:18818692|RGD:8554573
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	FZR1	IDA		Human	PMID:14701726
Cellular Component	GO:0031965	nuclear membrane	FZR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FZR1	IDA		Human	GO_REF:0000052
Biological Process	GO:0031145	anaphase-promoting complex-dependent catabolic process	FZR1	IDA		Human	PMID:14701726
Biological Process	GO:0031145	anaphase-promoting complex-dependent catabolic process	FZR1	IDA		Human	PMID:18662541
Biological Process	GO:0031145	anaphase-promoting complex-dependent catabolic process	FZR1	IDA		Human	PMID:21596315
Biological Process	GO:0070306	lens fiber cell differentiation	Fzr1	IMP		Mouse	PMID:17215516
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	FZR1	IDA		Human	PMID:18662541
Biological Process	GO:2000773	negative regulation of cellular senescence	Fzr1	IMP		Mouse	MGI:MGI:5009768|PMID:21241890
Biological Process	GO:0008284	positive regulation of cell population proliferation	Fzr1	IMP		Mouse	MGI:MGI:5009768|PMID:21241890
Biological Process	GO:1904668	positive regulation of ubiquitin protein ligase activity	FZR1	IDA		Human	PMID:11459826
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Fzr1	IMP		Mouse	PMID:23541922
Biological Process	GO:0040020	regulation of meiotic nuclear division	Fzr1	IDA		Mouse	PMID:17190794

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern