Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GABRA1
  • Mouse genes Gabra1
  • Rat genes Gabra1
  • Zfish genes gabra1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gabra1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050809	diazepam binding	Gabra1	IDA		Rat	PMID:1346133|RGD:728715
Molecular Function	GO:0050809	diazepam binding	Gabra1	IDA		Rat	PMID:2166916|RGD:61594
Molecular Function	GO:0016917	GABA receptor activity	Gabra1	IDA		Rat	PMID:12930820|RGD:8554754
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	GABRA1	IDA		Human	PMID:23909897
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	GABRA1	IDA		Human	PMID:9039914
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	Gabra1	IDA		Mouse	MGI:MGI:6208009|PMID:27129275
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	gabra1	IDA		Zfish	PMID:30580138
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Gabra1	IDA		Rat	PMID:22539847|RGD:13702433
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Gabra1	IMP		Rat	PMID:22539847|RGD:13702433
Molecular Function	GO:0097159	organic cyclic compound binding	Gabra1	IPI	CHEBI:10125|CHEBI:5103	Rat	PMID:1346133|RGD:728715
Molecular Function	GO:0005515	protein binding	Gabra1	IPI	UniProtKB:Q5U4E0	Mouse	MGI:MGI:6201911|PMID:29742426
Molecular Function	GO:0005515	protein binding	Gabra1	IPI	UniProtKB:Q7Z7J7	Mouse	MGI:MGI:6104059|PMID:28978485
Molecular Function	GO:0005515	protein binding	Gabra1	IPI	PR:P63328	Mouse	PMID:12574411
Molecular Function	GO:0005515	protein binding	Gabra1	IPI	UniProtKB:Q63787	Rat	PMID:16890252|RGD:8554051
Molecular Function	GO:0005515	protein binding	Gabra1	IPI	UniProtKB:P18508,UniProtKB:P63079,UniProtKB:P63138,UniProtKB:Q62888,UniProtKB:Q7TSY2	Rat	PMID:28279354|RGD:13800541
Molecular Function	GO:0005515	protein binding	Gabra1	IPI	UniProtKB:Q7TSY2	Rat	PMID:28279354|RGD:13800541
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Gabra1	IMP		Mouse	MGI:MGI:5819342|PMID:21994384
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Gabra1	IMP		Mouse	PMID:12466441
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Gabra1	IDA		Mouse	PMID:12466441
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Gabra1	EXP		Mouse	PMID:12466441
Cellular Component	GO:1902710	GABA receptor complex	Gabra1	IDA		Rat	PMID:12930820|RGD:8554754
Cellular Component	GO:1902711	GABA-A receptor complex	GABRA1	IPI		Human	PMID:29950725
Cellular Component	GO:1902711	GABA-A receptor complex	GABRA1	IPI		Human	PMID:30602789
Cellular Component	GO:1902711	GABA-A receptor complex	GABRA1	IDA		Human	PMID:30266951
Cellular Component	GO:1902711	GABA-A receptor complex	GABRA1	IDA		Human	PMID:9039914
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra1	IDA		Mouse	PMID:12466441
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra1	EXP		Mouse	PMID:12466441
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra1	IMP		Mouse	PMID:12466441
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra1	IDA		Rat	PMID:21073549|RGD:13702464
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra1	IDA		Rat	PMID:8613776|RGD:1626602
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra1	IDA		Rat	PMID:8876241|RGD:13702157
Cellular Component	GO:0016020	membrane	Gabra1	IDA		Rat	PMID:2166916|RGD:61594
Cellular Component	GO:0005886	plasma membrane	Gabra1	IDA		Mouse	MGI:MGI:5926673|PMID:25579817
Cellular Component	GO:0005886	plasma membrane	Gabra1	IDA		Rat	PMID:15152020|RGD:1358699
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabra1	IDA		Rat	PMID:21073549|RGD:13702464
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabra1	IDA		Rat	PMID:8613776|RGD:1626602
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabra1	IDA		Rat	PMID:8876241|RGD:13702157
Biological Process	GO:0071420	cellular response to histamine	Gabra1	IDA		Rat	PMID:18281286|RGD:8693370
Biological Process	GO:1902476	chloride transmembrane transport	GABRA1	IDA		Human	PMID:29950725
Biological Process	GO:1902476	chloride transmembrane transport	GABRA1	IDA		Human	PMID:30602789
Biological Process	GO:1902476	chloride transmembrane transport	GABRA1	IDA		Human	PMID:9039914
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	GABRA1	IDA		Human	PMID:29950725
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	GABRA1	IDA		Human	PMID:30602789
Biological Process	GO:1904862	inhibitory synapse assembly	GABRA1	IDA		Human	PMID:23909897
Biological Process	GO:1904862	inhibitory synapse assembly	GABRA1	IDA		Human	PMID:25489750
Biological Process	GO:1904862	inhibitory synapse assembly	Gabra1	IDA		Mouse	MGI:MGI:6208009|PMID:27129275
Biological Process	GO:0008345	larval locomotory behavior	gabra1	IMP	ZFIN:ZDB-MRPHLNO-201014-1	Zfish	PMID:32205311
Biological Process	GO:0008345	larval locomotory behavior	gabra1	IMP	ZFIN:ZDB-MRPHLNO-201014-2	Zfish	PMID:32205311
Biological Process	GO:0070208	protein heterotrimerization	gabra1	IDA		Zfish	PMID:30580138
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	Gabra1	IMP		Mouse	MGI:MGI:5819342|PMID:21994384
Biological Process	GO:0051932	synaptic transmission, GABAergic	Gabra1	IDA		Rat	PMID:12930820|RGD:8554754

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern