Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GABRA2
  • Mouse genes Gabra2
  • Rat genes Gabra2
  • Zfish genes gabra2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gabra2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008503	benzodiazepine receptor activity	GABRA2	IMP		Human	PMID:8391122
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	GABRA2	IDA		Human	PMID:9039914
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GABRA2	IDA		Human	PMID:22711532
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GABRA2	IMP		Human	PMID:22711532
Molecular Function	GO:0005515	protein binding	GABRA2	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Gabra2	IPI	UniProtKB:Q5U4E0	Mouse	MGI:MGI:6104059|PMID:28978485
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GABRA2	IDA		Human	PMID:22711532
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GABRA2	IMP		Human	PMID:22711532
Cellular Component	GO:0030424	axon	Gabra2	IDA		Mouse	PMID:9682826
Cellular Component	GO:0030425	dendrite	Gabra2	IDA		Mouse	PMID:24554721
Cellular Component	GO:0032590	dendrite membrane	Gabra2	IDA		Rat	PMID:15620359|RGD:8553937
Cellular Component	GO:1902711	GABA-A receptor complex	GABRA2	IDA		Human	PMID:9039914
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra2	IDA		Mouse	PMID:22666188
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra2	IDA		Mouse	PMID:14627650
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra2	IDA		Rat	PMID:11168550|RGD:155230774
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra2	IDA		Rat	PMID:21073549|RGD:13702464
Cellular Component	GO:0098982	GABA-ergic synapse	Gabra2	IDA		Rat	PMID:8876241|RGD:13702157
Cellular Component	GO:0060077	inhibitory synapse	Gabra2	IDA		Mouse	PMID:24554721
Cellular Component	GO:0043025	neuronal cell body	Gabra2	IDA		Mouse	PMID:24554721
Cellular Component	GO:0098794	postsynapse	Gabra2	IDA		Mouse	PMID:24554721
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabra2	IDA		Mouse	PMID:22666188
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabra2	IDA		Mouse	PMID:14627650
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabra2	IDA		Rat	PMID:11168550|RGD:155230774
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabra2	IDA		Rat	PMID:21073549|RGD:13702464
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabra2	IDA		Rat	PMID:8876241|RGD:13702157
Cellular Component	GO:0048787	presynaptic active zone membrane	Gabra2	IDA		Rat	PMID:11168550|RGD:155230774
Cellular Component	GO:0030672	synaptic vesicle membrane	GABRA2	IDA		Human	PMID:8391122
Biological Process	GO:1902476	chloride transmembrane transport	GABRA2	IDA		Human	PMID:9039914
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	GABRA2	IMP		Human	PMID:8391122
Biological Process	GO:1904862	inhibitory synapse assembly	Gabra2	IDA		Mouse	MGI:MGI:6208009|PMID:27129275
Biological Process	GO:0006836	neurotransmitter transport	GABRA2	IMP		Human	PMID:8391122
Biological Process	GO:0001505	regulation of neurotransmitter levels	GABRA2	IMP		Human	PMID:8391122

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern