Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GABRB1
  • Mouse genes Gabrb1
  • Rat genes Gabrb1
  • Zfish genes gabrb1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gabrb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0150047	G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	Gabrb1	IMP		Mouse	PMID:11498050
Molecular Function	GO:0150047	G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	Gabrb1	EXP		Mouse	PMID:11498050
Molecular Function	GO:0150047	G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	Gabrb1	IDA		Mouse	PMID:11498050
Molecular Function	GO:0050811	GABA receptor binding	Gabrb1	IPI	RGD:61859	Rat	PMID:17959749|RGD:6480233
Molecular Function	GO:0050811	GABA receptor binding	Gabrb1	IPI	RGD:621732	Rat	PMID:17959749|RGD:6480233
Molecular Function	GO:0004890	GABA-A receptor activity	Gabrb1	IMP		Rat	PMID:2540033|RGD:8693372
Molecular Function	GO:0004890	GABA-A receptor activity	Gabrb1	IDA		Rat	PMID:2548852|RGD:728451
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	GABRB1	IMP		Human	PMID:26950270
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	GABRB1	IDA		Human	PMID:9039914
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity	Gabrb1	IMP		Rat	PMID:2540033|RGD:8693372
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GABRB1	IDA		Human	PMID:26950270
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GABRB1	IMP		Human	PMID:26950270
Molecular Function	GO:0005253	monoatomic anion channel activity	Gabrb1	IDA		Rat	PMID:2479580|RGD:6480230
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Gabrb1	EXP		Rat	PMID:16469775|RGD:13792528
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Gabrb1	IDA		Rat	PMID:16469775|RGD:13792528
Cellular Component	GO:0005737	cytoplasm	Gabrb1	IDA		Rat	PMID:16226387|RGD:6480231
Cellular Component	GO:0030425	dendrite	Gabrb1	IDA		Rat	PMID:16226387|RGD:6480231
Cellular Component	GO:1902711	GABA-A receptor complex	GABRB1	IDA		Human	PMID:26950270
Cellular Component	GO:1902711	GABA-A receptor complex	GABRB1	IDA		Human	PMID:9039914
Cellular Component	GO:1902711	GABA-A receptor complex	Gabrb1	IMP		Rat	PMID:2540033|RGD:8693372
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb1	IDA		Mouse	PMID:11498050
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb1	IMP		Mouse	PMID:11498050
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb1	EXP		Mouse	PMID:11498050
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb1	IDA		Rat	PMID:15174078|RGD:155230705
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb1	EXP		Rat	PMID:16469775|RGD:13792528
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb1	IDA		Rat	PMID:16469775|RGD:13792528
Cellular Component	GO:0016020	membrane	Gabrb1	IDA		Rat	PMID:17959749|RGD:6480233
Cellular Component	GO:0005635	nuclear envelope	Gabrb1	IDA		Rat	PMID:20511229|RGD:6480235
Cellular Component	GO:0005634	nucleus	Gabrb1	IDA		Rat	PMID:20511229|RGD:6480235
Cellular Component	GO:0005886	plasma membrane	GABRB1	IDA		Human	PMID:26950270
Cellular Component	GO:0005886	plasma membrane	Gabrb1	IMP		Rat	PMID:2540033|RGD:8693372
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabrb1	IDA		Rat	PMID:15174078|RGD:155230705
Cellular Component	GO:0048787	presynaptic active zone membrane	Gabrb1	IDA		Rat	PMID:15174078|RGD:155230705
Cellular Component	GO:0043235	receptor complex	Gabrb1	IDA		Rat	PMID:17959749|RGD:6480233
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Gabrb1	IMP		Mouse	PMID:11498050
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Gabrb1	EXP		Mouse	PMID:11498050
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Gabrb1	IDA		Mouse	PMID:11498050
Biological Process	GO:0071420	cellular response to histamine	Gabrb1	IDA		Rat	PMID:18281286|RGD:8693370
Biological Process	GO:0021954	central nervous system neuron development	Gabrb1	IEP		Rat	PMID:15158077|RGD:6480239
Biological Process	GO:1902476	chloride transmembrane transport	GABRB1	IDA		Human	PMID:9039914
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Gabrb1	EXP		Mouse	MGI:MGI:2137778|PMID:11498050
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	GABRB1	IMP		Human	PMID:26950270
Biological Process	GO:0006811	monoatomic ion transport	Gabrb1	IMP		Rat	PMID:2540033|RGD:8693372
Biological Process	GO:0042698	ovulation cycle	Gabrb1	IEP		Rat	PMID:16226387|RGD:6480231
Biological Process	GO:0099505	regulation of presynaptic membrane potential	Gabrb1	EXP		Mouse	MGI:MGI:2137778|PMID:11498050
Biological Process	GO:0032570	response to progesterone	Gabrb1	IEP		Rat	PMID:15834956|RGD:6480238
Biological Process	GO:0009636	response to toxic substance	Gabrb1	IDA		Rat	PMID:2479580|RGD:6480230

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern