Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GABRB2
  • Mouse genes Gabrb2
  • Rat genes Gabrb2
  • Zfish genes gabrb2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gabrb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005254	chloride channel activity	Gabrb2	IMP		Rat	PMID:18281286|RGD:8693370
Molecular Function	GO:0016917	GABA receptor activity	GABRB2	IMP		Human	PMID:27789573
Molecular Function	GO:0016917	GABA receptor activity	Gabrb2	IDA		Rat	PMID:12930820|RGD:8554754
Molecular Function	GO:0004890	GABA-A receptor activity	Gabrb2	IMP		Rat	PMID:11877425|RGD:727351
Molecular Function	GO:0004890	GABA-A receptor activity	Gabrb2	IMP		Rat	PMID:18281286|RGD:8693370
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	GABRB2	IDA		Human	PMID:23909897
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	Gabrb2	IDA		Mouse	MGI:MGI:6208009|PMID:27129275
Molecular Function	GO:0022851	GABA-gated chloride ion channel activity	gabrb2a	IDA		Zfish	PMID:30580138
Molecular Function	GO:0005237	inhibitory extracellular ligand-gated monoatomic ion channel activity	Gabrb2	IMP		Rat	PMID:11877425|RGD:727351
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Gabrb2	IDA		Rat	PMID:26592470|RGD:155230766
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Gabrb2	IMP		Rat	PMID:26592470|RGD:155230766
Molecular Function	GO:0005515	protein binding	Gabrb2	IPI	PR:P63328	Mouse	PMID:12574411
Molecular Function	GO:0005515	protein binding	Gabrb2	IPI	RGD:2230	Rat	PMID:11350968|RGD:2316355
Molecular Function	GO:0005515	protein binding	Gabrb2	IPI	UniProtKB:Q8R2H7	Rat	PMID:12034717|RGD:625504
Molecular Function	GO:0005515	protein binding	Gabrb2	IPI	RGD:620296	Rat	PMID:22389504|RGD:9835374
Molecular Function	GO:0005515	protein binding	Gabrb2	IPI	UniProtKB:P18508,UniProtKB:P62813,UniProtKB:P63079,UniProtKB:Q62888,UniProtKB:Q7TSY2	Rat	PMID:28279354|RGD:13800541
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Gabrb2	IDA		Mouse	PMID:26179122
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Gabrb2	IMP		Mouse	PMID:26179122
Cellular Component	GO:0005829	cytosol	Gabrb2	IDA		Rat	PMID:17850559|RGD:2316354
Cellular Component	GO:0070062	extracellular exosome	GABRB2	HDA		Human	PMID:19056867
Cellular Component	GO:1902710	GABA receptor complex	Gabrb2	IDA		Rat	PMID:12930820|RGD:8554754
Cellular Component	GO:1902711	GABA-A receptor complex	GABRB2	IPI		Human	PMID:29950725
Cellular Component	GO:1902711	GABA-A receptor complex	Gabrb2	IMP		Rat	PMID:18281286|RGD:8693370
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb2	IDA		Mouse	PMID:26297893
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb2	IDA		Mouse	PMID:26179122
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb2	IMP		Mouse	PMID:26179122
Cellular Component	GO:0098982	GABA-ergic synapse	Gabrb2	IDA		Rat	PMID:15174078|RGD:155230705
Cellular Component	GO:0098978	glutamatergic synapse	Gabrb2	IDA		Rat	PMID:15174078|RGD:155230705
Cellular Component	GO:0016020	membrane	Gabrb2	IDA		Rat	PMID:17850559|RGD:2316354
Cellular Component	GO:0005886	plasma membrane	GABRB2	IDA		Human	PMID:27789573
Cellular Component	GO:0005886	plasma membrane	Gabrb2	IMP		Rat	PMID:18281286|RGD:8693370
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabrb2	IDA		Mouse	PMID:26297893
Cellular Component	GO:0099634	postsynaptic specialization membrane	Gabrb2	IDA		Rat	PMID:15174078|RGD:155230705
Cellular Component	GO:0048787	presynaptic active zone membrane	Gabrb2	IDA		Rat	PMID:15174078|RGD:155230705
Biological Process	GO:0071420	cellular response to histamine	Gabrb2	IDA		Rat	PMID:18281286|RGD:8693370
Biological Process	GO:0007268	chemical synaptic transmission	Gabrb2	IMP		Mouse	MGI:MGI:5662315|PMID:26179122
Biological Process	GO:0099565	chemical synaptic transmission, postsynaptic	Gabrb2	IMP		Mouse	MGI:MGI:5662315|PMID:26179122
Biological Process	GO:1902476	chloride transmembrane transport	GABRB2	IDA		Human	PMID:29950725
Biological Process	GO:1902476	chloride transmembrane transport	Gabrb2	IMP		Rat	PMID:18281286|RGD:8693370
Biological Process	GO:0090102	cochlea development	Gabrb2	IMP		Mouse	MGI:MGI:3664129|PMID:17021187
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	GABRB2	IMP		Human	PMID:27789573
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	GABRB2	IDA		Human	PMID:29950725
Biological Process	GO:1904862	inhibitory synapse assembly	GABRB2	IDA		Human	PMID:23909897
Biological Process	GO:1904862	inhibitory synapse assembly	GABRB2	IDA		Human	PMID:25489750
Biological Process	GO:1904862	inhibitory synapse assembly	Gabrb2	IDA		Mouse	MGI:MGI:6208009|PMID:27129275
Biological Process	GO:0060119	inner ear receptor cell development	Gabrb2	IMP		Mouse	MGI:MGI:3664129|PMID:17021187
Biological Process	GO:0060384	innervation	Gabrb2	IMP		Mouse	MGI:MGI:3664129|PMID:17021187
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Gabrb2	IMP		Mouse	MGI:MGI:5662315|PMID:26179122
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Gabrb2	IMP		Mouse	MGI:MGI:3664129|PMID:17021187
Biological Process	GO:1901215	negative regulation of neuron death	Gabrb2	IMP		Mouse	MGI:MGI:3664129|PMID:17021187
Biological Process	GO:0048666	neuron development	Gabrb2	IMP		Mouse	MGI:MGI:3664129|PMID:17021187
Biological Process	GO:0070208	protein heterotrimerization	gabrb2a	IDA		Zfish	PMID:30580138
Biological Process	GO:0043523	regulation of neuron apoptotic process	Gabrb2	IMP		Mouse	MGI:MGI:3664129|PMID:17021187
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	Gabrb2	IMP		Mouse	MGI:MGI:5662315|PMID:26179122
Biological Process	GO:0007605	sensory perception of sound	Gabrb2	IMP		Mouse	MGI:MGI:3664129|PMID:17021187
Biological Process	GO:0051932	synaptic transmission, GABAergic	Gabrb2	IDA		Rat	PMID:12930820|RGD:8554754

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern