Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GADD45A
  • Mouse genes Gadd45a
  • Rat genes Gadd45a
  • Zfish genes gadd45aa,gadd45ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gadd45a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019900	kinase binding	GADD45A	IPI	UniProtKB:O14965	Human	PMID:20460379
Molecular Function	GO:1990841	promoter-specific chromatin binding	Gadd45a	IDA		Mouse	PMID:22323595
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q8TAE8	Human	PMID:12716909
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:P49848	Human	PMID:15328371
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q13561	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:P28715	Human	PMID:17268471
Molecular Function	GO:0005515	protein binding	GADD45A	IDA		Human	PMID:20460379
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q13569	Human	PMID:21722948
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q9GZX7	Human	PMID:21722948
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:P80303	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q13561	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q9Y371	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q9WVE0	Human	PMID:23820005
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q13561	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q92600-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q9HBI0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q14204	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GADD45A	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Gadd45a	IPI	PR:P17918	Mouse	PMID:12124778
Molecular Function	GO:0005515	protein binding	Gadd45a	IPI	PR:P11440	Mouse	PMID:12124778
Molecular Function	GO:0005515	protein binding	Gadd45a	IPI	PR:P24860	Mouse	PMID:12124778
Molecular Function	GO:0046982	protein heterodimerization activity	GADD45A	IPI	UniProtKB:O14965	Human	PMID:20460379
Molecular Function	GO:0042803	protein homodimerization activity	GADD45A	IDA		Human	PMID:20460379
Cellular Component	GO:0005737	cytoplasm	GADD45A	IDA		Human	PMID:9827804
Cellular Component	GO:0016607	nuclear speck	GADD45A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GADD45A	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005634	nucleus	GADD45A	IDA		Human	PMID:9827804
Cellular Component	GO:0005634	nucleus	Gadd45a	IDA		Mouse	PMID:19796622
Biological Process	GO:0071479	cellular response to ionizing radiation	GADD45A	IMP		Human	PMID:20160708
Biological Process	GO:0071260	cellular response to mechanical stimulus	GADD45A	IEP		Human	PMID:19593445
Biological Process	GO:0007098	centrosome cycle	Gadd45a	IGI	MGI:MGI:104537	Mouse	PMID:15123655
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	Gadd45a	IEP		Rat	PMID:11964479|RGD:728684
Biological Process	GO:0016525	negative regulation of angiogenesis	Gadd45a	IMP		Mouse	MGI:MGI:6377865|PMID:23329839
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	GADD45A	IMP		Human	PMID:23329839
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	Gadd45a	IMP		Mouse	MGI:MGI:6377865|PMID:23329839
Biological Process	GO:0033140	negative regulation of peptidyl-serine phosphorylation of STAT protein	GADD45A	IMP		Human	PMID:23329839
Biological Process	GO:0033140	negative regulation of peptidyl-serine phosphorylation of STAT protein	Gadd45a	IMP		Mouse	MGI:MGI:6377865|PMID:23329839
Biological Process	GO:0006469	negative regulation of protein kinase activity	Gadd45a	IDA		Mouse	PMID:12124778
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	GADD45A	IMP		Human	PMID:23329839
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	GADD45A	IMP		Human	PMID:23329839
Biological Process	GO:0048339	paraxial mesoderm development	gadd45aa	IGI	ZFIN:ZDB-MRPHLNO-111005-2,ZFIN:ZDB-MRPHLNO-111005-5	Zfish	PMID:21784840
Biological Process	GO:0043065	positive regulation of apoptotic process	GADD45A	IDA		Human	PMID:9827804
Biological Process	GO:0046330	positive regulation of JNK cascade	GADD45A	IDA		Human	PMID:9827804
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	GADD45A	IDA		Human	PMID:9827804
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	GADD45A	IMP		Human	PMID:20160708
Biological Process	GO:0051726	regulation of cell cycle	Gadd45a	IDA		Mouse	PMID:12124778
Biological Process	GO:0042770	signal transduction in response to DNA damage	GADD45A	IMP		Human	PMID:20160708

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern