Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GAK
  • Mouse genes Gak
  • Rat genes Gak
  • Zfish genes gak
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gak

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030332	cyclin binding	Gak	IDA		Rat	PMID:9013862|RGD:728630
Molecular Function	GO:0005515	protein binding	GAK	IPI	UniProtKB:Q9NQ11	Human	PMID:22645275
Molecular Function	GO:0005515	protein binding	GAK	IPI	UniProtKB:P11142	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	GAK	IPI	UniProtKB:Q5S007	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	GAK	IPI	UniProtKB:Q5S007	Human	PMID:24947832
Molecular Function	GO:0005515	protein binding	GAK	IPI	UniProtKB:P11142	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	GAK	IPI	UniProtKB:Q5S007	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	GAK	IPI	UniProtKB:P11142	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	Gak	IPI	UniProtKB:P97378	Mouse	MGI:MGI:3762978|PMID:17937931
Molecular Function	GO:0005515	protein binding	Gak	IPI	PR:P45481	Mouse	PMID:15752756
Cellular Component	GO:0005829	cytosol	gak	IDA		Zfish	PMID:20082716
Cellular Component	GO:0005794	Golgi apparatus	GAK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	GAK	IDA		Human	PMID:16155256
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	GAK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	GAK	HDA		Human	PMID:19946888
Cellular Component	GO:0048471	perinuclear region of cytoplasm	gak	IDA		Zfish	PMID:20082716
Cellular Component	GO:0031982	vesicle	GAK	IDA		Human	PMID:24510904
Biological Process	GO:0048268	clathrin coat assembly	GAK	IMP		Human	PMID:16155256
Biological Process	GO:0072318	clathrin coat disassembly	GAK	IMP		Human	PMID:16155256
Biological Process	GO:0072318	clathrin coat disassembly	Gak	IGI	MGI:MGI:105384	Mouse	PMID:20160091
Biological Process	GO:0072583	clathrin-dependent endocytosis	GAK	IMP		Human	PMID:16155256
Biological Process	GO:0072583	clathrin-dependent endocytosis	Gak	IMP	MGI:MGI:5305733	Mouse	PMID:20160091
Biological Process	GO:0072583	clathrin-dependent endocytosis	Gak	IMP	MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0007029	endoplasmic reticulum organization	Gak	IMP	MGI:MGI:2176228,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0009913	epidermal cell differentiation	Gak	IMP	MGI:MGI:2445832,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0002064	epithelial cell development	Gak	IMP	MGI:MGI:2176228,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0061436	establishment of skin barrier	Gak	IMP	MGI:MGI:2176228,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0048853	forebrain morphogenesis	Gak	IMP	MGI:MGI:2176173,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0007030	Golgi organization	GAK	IMP		Human	PMID:16155256
Biological Process	GO:0007030	Golgi organization	GAK	IMP		Human	PMID:24510904
Biological Process	GO:0007030	Golgi organization	Gak	IMP	MGI:MGI:2176228,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0090160	Golgi to lysosome transport	GAK	IMP		Human	PMID:16155256
Biological Process	GO:0035622	intrahepatic bile duct development	Gak	IMP	MGI:MGI:2176228,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0030216	keratinocyte differentiation	Gak	IMP	MGI:MGI:2445832,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0010977	negative regulation of neuron projection development	GAK	IDA		Human	PMID:24510904
Biological Process	GO:0061351	neural precursor cell proliferation	Gak	IMP	MGI:MGI:2176173,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0060563	neuroepithelial cell differentiation	Gak	IMP	MGI:MGI:2445832,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Gak	IMP	MGI:MGI:2176173,MGI:MGI:5305733	Mouse	PMID:18434600
Biological Process	GO:0034067	protein localization to Golgi apparatus	GAK	IMP		Human	PMID:16155256
Biological Process	GO:0072659	protein localization to plasma membrane	GAK	IMP		Human	PMID:16155256
Biological Process	GO:0006898	receptor-mediated endocytosis	GAK	IMP		Human	PMID:16155256
Biological Process	GO:0048863	stem cell differentiation	Gak	IMP	MGI:MGI:2445832,MGI:MGI:5305733	Mouse	PMID:18434600

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern