Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GAS6
  • Mouse genes Gas6
  • Rat genes Gas6
  • Zfish genes gas6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gas6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GAS6	IDA		Human	PMID:16723520
Molecular Function	GO:0001786	phosphatidylserine binding	GAS6	IDA		Human	PMID:21501828
Molecular Function	GO:0005515	protein binding	GAS6	IPI	UniProtKB:P30530	Human	PMID:18760998
Molecular Function	GO:0005515	protein binding	GAS6	IPI	UniProtKB:P30530	Human	PMID:20088931
Molecular Function	GO:0005515	protein binding	GAS6	IPI	UniProtKB:Q12866	Human	PMID:20103767
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	GAS6	IDA		Human	PMID:20103767
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	GAS6	IDA		Human	PMID:21501828
Molecular Function	GO:0048018	receptor ligand activity	GAS6	IDA		Human	PMID:15184064
Molecular Function	GO:0048018	receptor ligand activity	Gas6	IDA		Mouse	PMID:9395235
Molecular Function	GO:0030971	receptor tyrosine kinase binding	GAS6	IPI	UniProtKB:Q06418	Human	PMID:7634325
Molecular Function	GO:0005102	signaling receptor binding	GAS6	IDA		Human	PMID:16359517
Molecular Function	GO:0005102	signaling receptor binding	GAS6	IPI	UniProtKB:P30530	Human	PMID:7854420
Cellular Component	GO:0005737	cytoplasm	GAS6	IDA		Human	PMID:18395422
Cellular Component	GO:0070062	extracellular exosome	GAS6	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	GAS6	IDA		Human	PMID:18395422
Cellular Component	GO:0005615	extracellular space	GAS6	IDA		Human	PMID:19922767
Cellular Component	GO:0005615	extracellular space	GAS6	IDA		Human	PMID:20088931
Cellular Component	GO:0005615	extracellular space	GAS6	IDA		Human	PMID:8336730
Cellular Component	GO:0005615	extracellular space	Gas6	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Gas6	IDA		Mouse	PMID:18188450
Cellular Component	GO:0005615	extracellular space	Gas6	IDA		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0032148	activation of protein kinase B activity	Gas6	IDA		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0031100	animal organ regeneration	Gas6	IEP		Rat	PMID:16285961|RGD:1579881
Biological Process	GO:0043277	apoptotic cell clearance	GAS6	IDA		Human	PMID:21501828
Biological Process	GO:0043277	apoptotic cell clearance	Gas6	IDA		Mouse	PMID:18159085
Biological Process	GO:0006915	apoptotic process	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:15184064
Biological Process	GO:0035754	B cell chemotaxis	GAS6	IDA		Human	PMID:19922767
Biological Process	GO:0007596	blood coagulation	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:15184064
Biological Process	GO:0070588	calcium ion transmembrane transport	GAS6	IDA		Human	PMID:18395422
Biological Process	GO:0031589	cell-substrate adhesion	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:18188450
Biological Process	GO:0071333	cellular response to glucose stimulus	Gas6	IDA		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0071363	cellular response to growth factor stimulus	Gas6	IDA		Mouse	PMID:8336730
Biological Process	GO:0071363	cellular response to growth factor stimulus	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:18188450
Biological Process	GO:0035457	cellular response to interferon-alpha	GAS6	IDA		Human	PMID:19657094
Biological Process	GO:0009267	cellular response to starvation	Gas6	IDA		Mouse	PMID:8336730
Biological Process	GO:0071307	cellular response to vitamin K	GAS6	IDA		Human	PMID:16359517
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	GAS6	IDA		Human	PMID:16359517
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Gas6	IDA		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0097028	dendritic cell differentiation	GAS6	IEP		Human	PMID:19657094
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	Gas6	IGI	MGI:MGI:1347244	Mouse	PMID:9395235
Biological Process	GO:0085029	extracellular matrix assembly	Gas6	IEP		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0044346	fibroblast apoptotic process	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:15184064
Biological Process	GO:0019064	fusion of virus membrane with host plasma membrane	GAS6	IDA		Human	PMID:21501828
Biological Process	GO:0097241	hematopoietic stem cell migration to bone marrow	GAS6	IDA		Human	PMID:19922767
Biological Process	GO:0010934	macrophage cytokine production	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:18188450
Biological Process	GO:0033028	myeloid cell apoptotic process	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:18188450
Biological Process	GO:0043066	negative regulation of apoptotic process	GAS6	IDA		Human	PMID:19922767
Biological Process	GO:0043066	negative regulation of apoptotic process	Gas6	IDA		Mouse	MGI:MGI:5315346|PMID:16723520
Biological Process	GO:0043066	negative regulation of apoptotic process	Gas6	IDA		Mouse	PMID:9395235
Biological Process	GO:0043066	negative regulation of apoptotic process	Gas6	IGI	MGI:MGI:1347244	Mouse	PMID:9395235
Biological Process	GO:0070168	negative regulation of biomineral tissue development	GAS6	IDA		Human	PMID:20048160
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GAS6	IDA		Human	PMID:16723520
Biological Process	GO:2000669	negative regulation of dendritic cell apoptotic process	GAS6	IDA		Human	PMID:19657094
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	GAS6	IDA		Human	PMID:18680538
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	GAS6	IDA		Human	PMID:18680538
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	GAS6	IDA		Human	PMID:16359517
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	GAS6	IDA		Human	PMID:18680538
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	GAS6	IDA		Human	PMID:18760998
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	GAS6	IDA		Human	PMID:16359517
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:15184064
Biological Process	GO:0032692	negative regulation of interleukin-1 production	GAS6	IDA		Human	PMID:20103767
Biological Process	GO:0032715	negative regulation of interleukin-6 production	GAS6	IDA		Human	PMID:19657094
Biological Process	GO:0032715	negative regulation of interleukin-6 production	GAS6	IDA		Human	PMID:20103767
Biological Process	GO:0033033	negative regulation of myeloid cell apoptotic process	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:18188450
Biological Process	GO:1900142	negative regulation of oligodendrocyte apoptotic process	GAS6	IDA		Human	PMID:16723520
Biological Process	GO:2000533	negative regulation of renal albumin absorption	Gas6	IEP		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	GAS6	IDA		Human	PMID:19657094
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	GAS6	IDA		Human	PMID:20103767
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	GAS6	IDA		Human	PMID:19657094
Biological Process	GO:0032689	negative regulation of type II interferon production	GAS6	IDA		Human	PMID:18840707
Biological Process	GO:0001764	neuron migration	Gas6	IGI	MGI:MGI:1347244	Mouse	PMID:18787040
Biological Process	GO:0018105	peptidyl-serine phosphorylation	GAS6	IDA		Human	PMID:18680538
Biological Process	GO:0018105	peptidyl-serine phosphorylation	GAS6	IDA		Human	PMID:20103767
Biological Process	GO:0006909	phagocytosis	GAS6	IDA		Human	PMID:21501828
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	GAS6	IMP		Human	PMID:18840707
Biological Process	GO:2000510	positive regulation of dendritic cell chemotaxis	GAS6	IDA		Human	PMID:19657094
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GAS6	IDA		Human	PMID:15184064
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	GAS6	IDA		Human	PMID:15184064
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	GAS6	IDA		Human	PMID:7854420
Biological Process	GO:0010628	positive regulation of gene expression	GAS6	IDA		Human	PMID:19657094
Biological Process	GO:0003104	positive regulation of glomerular filtration	Gas6	IDA		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	GAS6	IDA		Human	PMID:18840707
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GAS6	IDA		Human	PMID:16723520
Biological Process	GO:0050766	positive regulation of phagocytosis	GAS6	IDA		Human	PMID:18395422
Biological Process	GO:0046827	positive regulation of protein export from nucleus	GAS6	IDA		Human	PMID:18680538
Biological Process	GO:0045860	positive regulation of protein kinase activity	GAS6	IDA		Human	PMID:7854420
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	GAS6	IDA		Human	PMID:16359517
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	GAS6	IDA		Human	PMID:16723520
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	GAS6	IDA		Human	PMID:18680538
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Gas6	IDA		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0001934	positive regulation of protein phosphorylation	GAS6	IDA		Human	PMID:16723520
Biological Process	GO:0001934	positive regulation of protein phosphorylation	GAS6	IDA		Human	PMID:20103767
Biological Process	GO:0001934	positive regulation of protein phosphorylation	GAS6	IDA		Human	PMID:7854420
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Gas6	IDA		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	GAS6	IDA		Human	PMID:20103767
Biological Process	GO:0032008	positive regulation of TOR signaling	Gas6	IDA		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0043491	protein kinase B signaling	GAS6	IDA		Human	PMID:16723520
Biological Process	GO:0043491	protein kinase B signaling	GAS6	IDA		Human	PMID:20103767
Biological Process	GO:0043491	protein kinase B signaling	Gas6	IMP	MGI:MGI:2675495	Mouse	PMID:18188450
Biological Process	GO:0043491	protein kinase B signaling	Gas6	IGI	MGI:MGI:96965	Mouse	PMID:15650770
Biological Process	GO:0043491	protein kinase B signaling	Gas6	IGI	MGI:MGI:1347244	Mouse	PMID:15650770
Biological Process	GO:0043491	protein kinase B signaling	Gas6	IGI	MGI:MGI:104294	Mouse	PMID:15650770
Biological Process	GO:0072659	protein localization to plasma membrane	GAS6	IDA		Human	PMID:16359517
Biological Process	GO:0006468	protein phosphorylation	GAS6	IDA		Human	PMID:16359517
Biological Process	GO:0046813	receptor-mediated virion attachment to host cell	GAS6	IDA		Human	PMID:21501828
Biological Process	GO:0007165	signal transduction	GAS6	IDA		Human	PMID:18680538
Biological Process	GO:0007165	signal transduction	GAS6	IDA		Human	PMID:7854420
Biological Process	GO:0007165	signal transduction	Gas6	IDA		Rat	PMID:18374201|RGD:8554638
Biological Process	GO:0002040	sprouting angiogenesis	gas6	IMP	ZFIN:ZDB-MRPHLNO-140425-1	Zfish	PMID:24409287
Biological Process	GO:0002040	sprouting angiogenesis	gas6	IMP	ZFIN:ZDB-MRPHLNO-140425-2	Zfish	PMID:24409287
Biological Process	GO:0046718	viral entry into host cell	GAS6	IDA		Human	PMID:21501828
Biological Process	GO:0019079	viral genome replication	GAS6	IDA		Human	PMID:21501828

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern