Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GATA2
  • Mouse genes Gata2
  • Rat genes Gata2
  • Zfish genes gata2a,gata2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gata2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070742	C2H2 zinc finger domain binding	GATA2	IPI	UniProtKB:Q8IX07	Human	PMID:12483298
Molecular Function	GO:0003682	chromatin binding	GATA2	IDA		Human	PMID:19242469
Molecular Function	GO:0003682	chromatin binding	Gata2	IDA		Mouse	PMID:18779319
Molecular Function	GO:0003682	chromatin binding	Gata2	IDA		Mouse	PMID:18184866
Molecular Function	GO:0003677	DNA binding	Gata2	IDA		Mouse	PMID:12023274
Molecular Function	GO:0003677	DNA binding	Gata2	IDA		Mouse	PMID:10367888
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Gata2	IDA		Mouse	PMID:16254139
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Gata2	IDA		Mouse	PMID:7720565
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Gata2	IDA		Mouse	PMID:9305891
Molecular Function	GO:0003700	DNA-binding transcription factor activity	GATA2	IDA		Human	PMID:15016828
Molecular Function	GO:0003700	DNA-binding transcription factor activity	GATA2	IDA		Human	PMID:20206639
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GATA2	IDA		Human	PMID:27780851
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P29590-4	Human	PMID:10938104
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P07327	Human	PMID:16153155
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P17947	Human	PMID:18250304
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q92793	Human	PMID:18250304
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q13485	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q8WW38	Human	PMID:20705609
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q13485	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P10275	Human	PMID:23887938
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q8IX12	Human	PMID:23887938
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P25788	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P36406	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P86479	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q13077	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q13643	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q6UY14-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P25788	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P36406	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q08379	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q13643	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q7Z3S9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q99750	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P35548	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q3LI59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q3SY46	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q8IUC1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q8IUC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q8IUC3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q93062-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q9BYR8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:Q92793	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	GATA2	IPI	UniProtKB:P25801	Human	PMID:7568177
Molecular Function	GO:0005515	protein binding	Gata2	IPI	PR:Q00286	Mouse	PMID:10367888
Molecular Function	GO:0005515	protein binding	Gata2	IPI	RGD:2319357	Rat	PMID:12557015|RGD:9587809
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Gata2	IDA		Mouse	PMID:17962413
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Gata2	IDA		Mouse	PMID:21245044
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	GATA2	IPI	UniProtKB:Q03014	Human	PMID:15016828
Molecular Function	GO:0043565	sequence-specific DNA binding	Gata2	IDA		Rat	PMID:11093771|RGD:9587814
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	GATA2	IDA		Human	PMID:28473536
Molecular Function	GO:0001223	transcription coactivator binding	Gata2	IPI	UniProtKB:Q925J9	Mouse	MGI:MGI:2158098|PMID:11724781
Molecular Function	GO:0001221	transcription coregulator binding	GATA2	IPI	UniProtKB:Q8IX07	Human	PMID:12483298
Cellular Component	GO:0005737	cytoplasm	GATA2	IDA		Human	PMID:27780851
Cellular Component	GO:0005654	nucleoplasm	GATA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GATA2	IDA		Human	PMID:27780851
Cellular Component	GO:0005634	nucleus	Gata2	IDA		Mouse	PMID:9305891
Cellular Component	GO:0005634	nucleus	Gata2	IDA		Rat	PMID:11093771|RGD:9587814
Cellular Component	GO:0005667	transcription regulator complex	Gata2	IDA		Mouse	PMID:19323994
Biological Process	GO:0001525	angiogenesis	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:9043071
Biological Process	GO:0003190	atrioventricular valve formation	gata2a	IMP	ZFIN:ZDB-MRPHLNO-050208-12	Zfish	PMID:19924233
Biological Process	GO:0050873	brown fat cell differentiation	Gata2	IMP		Mouse	PMID:16082385
Biological Process	GO:0021533	cell differentiation in hindbrain	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:10357893
Biological Process	GO:0001709	cell fate determination	Gata2	IDA		Mouse	PMID:10367888
Biological Process	GO:0021954	central nervous system neuron development	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:10357893
Biological Process	GO:0090102	cochlea development	Gata2	IEP		Rat	PMID:20006695|RGD:9479067
Biological Process	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain	Gata2	IMP	MGI:MGI:4818492	Mouse	PMID:22991444
Biological Process	GO:0060216	definitive hemopoiesis	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:9822612
Biological Process	GO:0060216	definitive hemopoiesis	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:8078582
Biological Process	GO:0060216	definitive hemopoiesis	gata2b	IMP	ZFIN:ZDB-MRPHLNO-150601-4	Zfish	PMID:25758220
Biological Process	GO:0035912	dorsal aorta morphogenesis	gata2a	IMP	ZFIN:ZDB-GENO-111201-5	Zfish	PMID:21937602
Biological Process	GO:0001892	embryonic placenta development	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:9043071
Biological Process	GO:0035854	eosinophil fate commitment	GATA2	IDA		Human	PMID:12045236
Biological Process	GO:0048821	erythrocyte development	gata2a	IMP	ZFIN:ZDB-MRPHLNO-050208-12	Zfish	PMID:19924233
Biological Process	GO:0097154	GABAergic neuron differentiation	Gata2	IMP	MGI:MGI:4818492	Mouse	PMID:22991444
Biological Process	GO:0002067	glandular epithelial cell differentiation	Gata2	IMP	MGI:MGI:2179995,MGI:MGI:3628639	Mouse	PMID:16543408
Biological Process	GO:0002071	glandular epithelial cell maturation	Gata2	IMP	MGI:MGI:2179995,MGI:MGI:3628639	Mouse	PMID:16543408
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Gata2	IMP		Mouse	PMID:16621992
Biological Process	GO:0060218	hematopoietic stem cell differentiation	gata2b	IMP	ZFIN:ZDB-MRPHLNO-150601-4	Zfish	PMID:25758220
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:15811962
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:15811962
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Gata2	IGI	MGI:MGI:95661	Mouse	PMID:14504093
Biological Process	GO:0042472	inner ear morphogenesis	Gata2	IMP	MGI:MGI:4818492	Mouse	PMID:20652952
Biological Process	GO:0030099	myeloid cell differentiation	Gata2	IMP		Mouse	PMID:16621992
Biological Process	GO:1903444	negative regulation of brown fat cell differentiation	Gata2	IMP		Mouse	PMID:16082385
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	GATA2	IMP		Human	PMID:21788589
Biological Process	GO:0045599	negative regulation of fat cell differentiation	GATA2	IMP		Human	PMID:20705609
Biological Process	GO:0070345	negative regulation of fat cell proliferation	GATA2	IMP		Human	PMID:20705609
Biological Process	GO:0010629	negative regulation of gene expression	GATA2	IMP		Human	PMID:27780851
Biological Process	GO:1901533	negative regulation of hematopoietic progenitor cell differentiation	Gata2	IMP		Mouse	PMID:16621992
Biological Process	GO:0045650	negative regulation of macrophage differentiation	Gata2	IDA		Mouse	PMID:16254139
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	Gata2	IMP		Mouse	PMID:16621992
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	GATA2	IDA		Human	PMID:16672344
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:16672344
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	GATA2	IDA		Human	PMID:16672344
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Gata2	IDA		Mouse	PMID:16082385
Biological Process	GO:0061351	neural precursor cell proliferation	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:16672344
Biological Process	GO:0007405	neuroblast proliferation	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:16672344
Biological Process	GO:0061101	neuroendocrine cell differentiation	Gata2	IMP	MGI:MGI:2179995,MGI:MGI:3628639	Mouse	PMID:16543408
Biological Process	GO:0030182	neuron differentiation	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:10357893
Biological Process	GO:0030182	neuron differentiation	Gata2	IMP		Mouse	PMID:14973276
Biological Process	GO:0048663	neuron fate commitment	Gata2	IMP	MGI:MGI:4818492	Mouse	PMID:19088086
Biological Process	GO:0042551	neuron maturation	Gata2	IMP	MGI:MGI:2179995,MGI:MGI:3628639	Mouse	PMID:16543408
Biological Process	GO:0001764	neuron migration	Gata2	IMP		Rat	PMID:21430145|RGD:9587810
Biological Process	GO:0021983	pituitary gland development	Gata2	IMP	MGI:MGI:2179995,MGI:MGI:3628639	Mouse	PMID:16543408
Biological Process	GO:0045766	positive regulation of angiogenesis	GATA2	IDA		Human	PMID:19242469
Biological Process	GO:0045766	positive regulation of angiogenesis	GATA2	IMP		Human	PMID:21788589
Biological Process	GO:0045766	positive regulation of angiogenesis	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:9043071
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	GATA2	IMP		Human	PMID:22499991
Biological Process	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GATA2	IMP		Human	PMID:27780851
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GATA2	IMP		Human	PMID:27780851
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Gata2	IMP		Rat	PMID:22390417|RGD:9587812
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	Gata2	IDA		Mouse	PMID:16254139
Biological Process	GO:0010628	positive regulation of gene expression	GATA2	IMP		Human	PMID:22499991
Biological Process	GO:0010628	positive regulation of gene expression	GATA2	IMP		Human	PMID:27780851
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Gata2	IMP		Rat	PMID:22390417|RGD:9587812
Biological Process	GO:0045654	positive regulation of megakaryocyte differentiation	Gata2	IDA		Mouse	PMID:16254139
Biological Process	GO:1902895	positive regulation of miRNA transcription	GATA2	IDA		Human	PMID:27780851
Biological Process	GO:1902895	positive regulation of miRNA transcription	GATA2	IGI	UniProtKB:Q96SQ7	Human	PMID:27780851
Biological Process	GO:0045666	positive regulation of neuron differentiation	Gata2	IMP		Rat	PMID:21430145|RGD:9587810
Biological Process	GO:0050766	positive regulation of phagocytosis	Gata2	IDA		Rat	PMID:12933836|RGD:632788
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	Gata2	IMP		Rat	PMID:12933836|RGD:632788
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GATA2	IMP		Human	PMID:19242469
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GATA2	IGI	UniProtKB:P70662	Human	PMID:19323994
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GATA2	IDA		Human	PMID:15016828
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GATA2	IDA		Human	PMID:16153155
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GATA2	IDA		Human	PMID:20206639
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GATA2	IDA		Human	PMID:21788589
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IGI	UniProtKB:P28069	Mouse	PMID:18653622
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IGI	MGI:MGI:98510	Mouse	PMID:18184866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IDA		Mouse	PMID:7720565
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IGI	MGI:MGI:102811	Mouse	PMID:18184866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IMP	MGI:MGI:4818492	Mouse	PMID:22991444
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IGI	MGI:MGI:98480	Mouse	PMID:18184866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IGI	MGI:MGI:97588	Mouse	PMID:9305891
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:9043071
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IGI	MGI:MGI:894762	Mouse	PMID:18184866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gata2	IMP		Rat	PMID:11093771|RGD:9587814
Biological Process	GO:0060215	primitive hemopoiesis	gata2a	IGI	ZFIN:ZDB-GENO-070810-1,ZFIN:ZDB-MRPHLNO-050208-12	Zfish	PMID:19843882
Biological Process	GO:2000977	regulation of forebrain neuron differentiation	Gata2	IMP	MGI:MGI:4818492	Mouse	PMID:22991444
Biological Process	GO:0035065	regulation of histone acetylation	Gata2	IDA		Mouse	PMID:16254139
Biological Process	GO:0010725	regulation of primitive erythrocyte differentiation	Gata2	IGI	MGI:MGI:95661	Mouse	PMID:14504093
Biological Process	GO:0033993	response to lipid	Gata2	IEP		Rat	PMID:11880336|RGD:7242278
Biological Process	GO:0060872	semicircular canal development	Gata2	IMP	MGI:MGI:4818492	Mouse	PMID:20652952
Biological Process	GO:0035019	somatic stem cell population maintenance	Gata2	IMP		Mouse	PMID:16082385
Biological Process	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	Gata2	IMP	MGI:MGI:2179995,MGI:MGI:3628639	Mouse	PMID:16543408
Biological Process	GO:0006366	transcription by RNA polymerase II	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:9043071
Biological Process	GO:0006366	transcription by RNA polymerase II	Gata2	IMP	MGI:MGI:4818492	Mouse	PMID:22991444
Biological Process	GO:0001655	urogenital system development	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:9822612
Biological Process	GO:0061042	vascular wound healing	GATA2	IMP		Human	PMID:22499991
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	Gata2	IMP	MGI:MGI:1857743	Mouse	PMID:10934027
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	gata2a	IMP	ZFIN:ZDB-MRPHLNO-050208-12	Zfish	PMID:20610488

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern