Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GBA2
  • Mouse genes Gba2
  • Rat genes Gba2
  • Zfish genes gba2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gba2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008422	beta-glucosidase activity	GBA2	IDA		Human	PMID:11489889
Molecular Function	GO:0008422	beta-glucosidase activity	Gba2	IDA		Mouse	PMID:22659419
Molecular Function	GO:0008422	beta-glucosidase activity	Gba2	IMP		Mouse	PMID:22659419
Molecular Function	GO:0008422	beta-glucosidase activity	gba2	IDA		Zfish	PMID:26909767
Molecular Function	GO:0004348	glucosylceramidase activity	GBA2	IDA		Human	PMID:17080196
Molecular Function	GO:0004348	glucosylceramidase activity	Gba2	IDA		Mouse	MGI:MGI:5484792|PMID:23250757
Molecular Function	GO:0004348	glucosylceramidase activity	Gba2	IDA		Mouse	MGI:MGI:3690511|PMID:17080196
Molecular Function	GO:0004348	glucosylceramidase activity	Gba2	IMP		Mouse	PMID:22659419
Molecular Function	GO:0004348	glucosylceramidase activity	Gba2	IDA		Mouse	PMID:22659419
Molecular Function	GO:0046527	glucosyltransferase activity	Gba2	IDA		Mouse	MGI:MGI:3690511|PMID:17080196
Molecular Function	GO:0046527	glucosyltransferase activity	Gba2	IDA		Mouse	MGI:MGI:5771619|PMID:26724485
Molecular Function	GO:0050295	steryl-beta-glucosidase activity	Gba2	IDA		Mouse	MGI:MGI:5771619|PMID:26724485
Cellular Component	GO:0005829	cytosol	Gba2	IDA		Mouse	MGI:MGI:5484792|PMID:23250757
Cellular Component	GO:0042406	extrinsic component of endoplasmic reticulum membrane	Gba2	IDA		Mouse	MGI:MGI:5484792|PMID:23250757
Cellular Component	GO:0090498	extrinsic component of Golgi membrane	Gba2	IDA		Mouse	MGI:MGI:5484792|PMID:23250757
Cellular Component	GO:0019898	extrinsic component of membrane	Gba2	IDA		Mouse	MGI:MGI:5484792|PMID:23250757
Cellular Component	GO:0016020	membrane	GBA2	IDA		Human	PMID:17105727
Cellular Component	GO:0005886	plasma membrane	gba2	IDA		Zfish	PMID:26909767
Biological Process	GO:0007409	axonogenesis	gba2	IMP	ZFIN:ZDB-MRPHLNO-130408-1	Zfish	PMID:23332916
Biological Process	GO:0008206	bile acid metabolic process	GBA2	IDA		Human	PMID:17105727
Biological Process	GO:0007417	central nervous system development	gba2	IMP	ZFIN:ZDB-MRPHLNO-130408-1	Zfish	PMID:23332916
Biological Process	GO:0021954	central nervous system neuron development	GBA2	IMP		Human	PMID:23332916
Biological Process	GO:0008203	cholesterol metabolic process	Gba2	IMP		Mouse	MGI:MGI:5771619|PMID:26724485
Biological Process	GO:0006680	glucosylceramide catabolic process	GBA2	IDA		Human	PMID:17080196
Biological Process	GO:0006680	glucosylceramide catabolic process	GBA2	IMP		Human	PMID:30308956
Biological Process	GO:0006680	glucosylceramide catabolic process	Gba2	IDA		Mouse	MGI:MGI:5484792|PMID:23250757
Biological Process	GO:0006680	glucosylceramide catabolic process	Gba2	IMP		Mouse	MGI:MGI:3690511|PMID:17080196
Biological Process	GO:0006678	glucosylceramide metabolic process	gba2	IMP	ZFIN:ZDB-GENO-220720-2	Zfish	PMID:31562193
Biological Process	GO:0006678	glucosylceramide metabolic process	gba2	IGI	ZFIN:ZDB-GENO-220720-3	Zfish	PMID:31562193
Biological Process	GO:0016139	glycoside catabolic process	GBA2	IDA		Human	PMID:17105727
Biological Process	GO:0030259	lipid glycosylation	Gba2	IDA		Mouse	MGI:MGI:5771619|PMID:26724485
Biological Process	GO:0030833	regulation of actin filament polymerization	Gba2	IMP		Mouse	MGI:MGI:5661753|PMID:25803043
Biological Process	GO:0097035	regulation of membrane lipid distribution	Gba2	IMP		Mouse	MGI:MGI:5661753|PMID:25803043
Biological Process	GO:0031113	regulation of microtubule polymerization	Gba2	IMP		Mouse	MGI:MGI:5661753|PMID:25803043

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern