Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gbp2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GBP1,GBP2
- Mouse genes Gbp2
- Rat genes Gbp2
- Zfish genes gbp2,gbp3,gbp4
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gbp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	GBP1	IDA		Human	PMID:24337748
Molecular Function	GO:0019955	cytokine binding	GBP1	IPI	UniProtKB:Q12904	Human	PMID:24337748
Molecular Function	GO:0019899	enzyme binding	GBP1	IPI	UniProtKB:P06733	Human	PMID:24337748
Molecular Function	GO:0019899	enzyme binding	GBP1	IPI	UniProtKB:P07814	Human	PMID:24337748
Molecular Function	GO:0019899	enzyme binding	GBP1	IPI	UniProtKB:P41252	Human	PMID:24337748
Molecular Function	GO:0003925	G protein activity	GBP1	IDA		Human	PMID:16511497
Molecular Function	GO:0003925	G protein activity	GBP1	IDA		Human	PMID:28645896
Molecular Function	GO:0003925	G protein activity	GBP1	IDA		Human	PMID:29144452
Molecular Function	GO:0003925	G protein activity	GBP1	IDA		Human	PMID:29233899
Molecular Function	GO:0003925	G protein activity	GBP1	IDA		Human	PMID:7512561
Molecular Function	GO:0019003	GDP binding	GBP1	IDA		Human	PMID:10676968
Molecular Function	GO:0004382	GDP phosphatase activity	GBP1	IDA		Human	PMID:16511497
Molecular Function	GO:0004382	GDP phosphatase activity	GBP1	IDA		Human	PMID:28645896
Molecular Function	GO:0004382	GDP phosphatase activity	GBP1	IDA		Human	PMID:7512561
Molecular Function	GO:0005525	GTP binding	GBP1	IDA		Human	PMID:10676968
Molecular Function	GO:0005525	GTP binding	GBP1	IDA		Human	PMID:10970849
Molecular Function	GO:0003924	GTPase activity	GBP1	IDA		Human	PMID:10676968
Molecular Function	GO:0003924	GTPase activity	GBP1	IDA		Human	PMID:16511497
Molecular Function	GO:0003924	GTPase activity	GBP1	IDA		Human	PMID:28645896
Molecular Function	GO:0003924	GTPase activity	GBP1	IDA		Human	PMID:29144452
Molecular Function	GO:0003924	GTPase activity	GBP1	IDA		Human	PMID:29233899
Molecular Function	GO:0003924	GTPase activity	GBP1	IDA		Human	PMID:31268602
Molecular Function	GO:0003924	GTPase activity	GBP1	IDA		Human	PMID:7512561
Molecular Function	GO:0051879	Hsp90 protein binding	GBP1	IPI	UniProtKB:P07900	Human	PMID:24337748
Molecular Function	GO:0042802	identical protein binding	GBP1	IPI	UniProtKB:P32455	Human	PMID:16511497
Molecular Function	GO:0042802	identical protein binding	GBP1	IPI	UniProtKB:P32455	Human	PMID:21151871
Molecular Function	GO:0042802	identical protein binding	GBP1	IPI	UniProtKB:P32455	Human	PMID:22059445
Molecular Function	GO:0042802	identical protein binding	GBP1	IPI	UniProtKB:P32455	Human	PMID:22607347
Molecular Function	GO:0042802	identical protein binding	GBP2	IPI	UniProtKB:P32456	Human	PMID:21151871
Molecular Function	GO:0140678	molecular function inhibitor activity	GBP2	IDA		Human	PMID:31091448
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:P32456	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:Q96PP8	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:Q96PP9	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:Q96PP9\|UniProtKB:Q9H0R5	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:Q9H0R5	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:P13796	Human	PMID:24337748
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:P67809	Human	PMID:24337748
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:Q53HL1	Human	PMID:24337748
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:Q9UJZ1	Human	PMID:24337748
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:P32456	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:Q96PP8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	GBP1	IPI	UniProtKB:Q9H0R5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	GBP2	IPI	UniProtKB:Q9WMX2:PRO_0000037548	Human	PMID:18985028
Molecular Function	GO:0005515	protein binding	GBP2	IPI	UniProtKB:P32455	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP2	IPI	UniProtKB:Q96PP8	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP2	IPI	UniProtKB:Q96PP9	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP2	IPI	UniProtKB:Q96PP9\|UniProtKB:Q9H0R5	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP2	IPI	UniProtKB:Q9H0R5	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP2	IPI	UniProtKB:P32455	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	GBP2	IPI	UniProtKB:Q9H0R5	Human	PMID:28514442
Molecular Function	GO:0042803	protein homodimerization activity	GBP1	IDA		Human	PMID:10676968
Molecular Function	GO:0042803	protein homodimerization activity	GBP1	IDA		Human	PMID:21151871
Molecular Function	GO:0042803	protein homodimerization activity	GBP2	IDA		Human	PMID:21151871
Molecular Function	GO:0030507	spectrin binding	GBP1	IPI	UniProtKB:Q01082	Human	PMID:24337748
Cellular Component	GO:0015629	actin cytoskeleton	GBP1	IDA		Human	PMID:21151871
Cellular Component	GO:0005737	cytoplasm	GBP1	IDA		Human	PMID:17266443
Cellular Component	GO:0005737	cytoplasm	GBP1	IDA		Human	PMID:21151871
Cellular Component	GO:0005737	cytoplasm	GBP2	IDA		Human	PMID:21151871
Cellular Component	GO:0031410	cytoplasmic vesicle	GBP1	IDA		Human	PMID:29144452
Cellular Component	GO:0031410	cytoplasmic vesicle	Gbp2	IDA		Mouse	MGI:MGI:6829596\|PMID:31964735
Cellular Component	GO:0031410	cytoplasmic vesicle	Gbp2	IDA		Mouse	PMID:18025219
Cellular Component	GO:0005829	cytosol	GBP1	IDA		Human	PMID:24337748
Cellular Component	GO:0005829	cytosol	GBP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	GBP1	IDA		Human	PMID:17266443
Cellular Component	GO:0005794	Golgi apparatus	GBP2	IDA		Human	PMID:31091448
Cellular Component	GO:0005794	Golgi apparatus	GBP2	IDA		Human	PMID:17266443
Cellular Component	GO:0000139	Golgi membrane	GBP2	IDA		Human	PMID:31091448
Cellular Component	GO:0005654	nucleoplasm	GBP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GBP2	IDA		Human	PMID:17266443
Cellular Component	GO:0005634	nucleus	GBP2	IDA		Human	PMID:21151871
Cellular Component	GO:0048471	perinuclear region of cytoplasm	GBP2	IDA		Human	PMID:17266443
Cellular Component	GO:0106139	symbiont cell surface	GBP1	IDA		Human	PMID:29144452
Cellular Component	GO:0106139	symbiont cell surface	GBP1	IDA		Human	PMID:29233899
Cellular Component	GO:0106139	symbiont cell surface	Gbp2	IDA		Mouse	PMID:27693356
Cellular Component	GO:0020005	symbiont-containing vacuole membrane	Gbp2	IDA		Mouse	PMID:18025219
Cellular Component	GO:0012506	vesicle membrane	GBP1	IDA		Human	PMID:29144452
Cellular Component	GO:0012506	vesicle membrane	GBP1	IDA		Human	PMID:29233899
Cellular Component	GO:0012506	vesicle membrane	GBP1	IDA		Human	PMID:21151871
Cellular Component	GO:0012506	vesicle membrane	GBP1	IDA		Human	PMID:31268602
Biological Process	GO:0002218	activation of innate immune response	Gbp2	IMP		Mouse	MGI:MGI:5571540\|PMID:24739961
Biological Process	GO:0044406	adhesion of symbiont to host	Gbp2	IDA		Mouse	PMID:18025219
Biological Process	GO:0140632	canonical inflammasome complex assembly	GBP1	IDA		Human	PMID:31268602
Biological Process	GO:0035458	cellular response to interferon-beta	Gbp2	IDA		Mouse	MGI:MGI:4412460\|PMID:18025219
Biological Process	GO:0035458	cellular response to interferon-beta	Gbp2	IDA		Mouse	PMID:19158679
Biological Process	GO:0071347	cellular response to interleukin-1	GBP1	IEP		Human	PMID:17266443
Biological Process	GO:0071347	cellular response to interleukin-1	GBP2	IEP		Human	PMID:17266443
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Gbp2	IMP		Mouse	MGI:MGI:5565107\|PMID:24715728
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Gbp2	IDA		Mouse	PMID:18025219
Biological Process	GO:0071356	cellular response to tumor necrosis factor	GBP1	IEP		Human	PMID:17266443
Biological Process	GO:0071356	cellular response to tumor necrosis factor	GBP2	IEP		Human	PMID:17266443
Biological Process	GO:0071346	cellular response to type II interferon	GBP1	IDA		Human	PMID:17266443
Biological Process	GO:0071346	cellular response to type II interferon	GBP1	IDA		Human	PMID:21151871
Biological Process	GO:0071346	cellular response to type II interferon	GBP2	IDA		Human	PMID:17266443
Biological Process	GO:0071346	cellular response to type II interferon	Gbp2	IDA		Mouse	PMID:18025219
Biological Process	GO:0051715	cytolysis in another organism	GBP1	IDA		Human	PMID:31268602
Biological Process	GO:0051715	cytolysis in another organism	Gbp2	IDA		Mouse	MGI:MGI:5774628\|PMID:25774715
Biological Process	GO:0051715	cytolysis in another organism	Gbp2	IMP		Mouse	MGI:MGI:5571540\|PMID:24739961
Biological Process	GO:0051715	cytolysis in another organism	Gbp2	IDA		Mouse	MGI:MGI:5774627\|PMID:25774716
Biological Process	GO:0051715	cytolysis in another organism	Gbp2	IMP		Mouse	MGI:MGI:5565107\|PMID:24715728
Biological Process	GO:0042742	defense response to bacterium	Gbp2	IMP		Mouse	MGI:MGI:5571540\|PMID:24739961
Biological Process	GO:0042742	defense response to bacterium	Gbp2	IMP		Mouse	MGI:MGI:5565107\|PMID:24715728
Biological Process	GO:0042742	defense response to bacterium	Gbp2	IDA		Mouse	MGI:MGI:7432484\|PMID:30062052
Biological Process	GO:0042742	defense response to bacterium	Gbp2	IDA		Mouse	MGI:MGI:5774628\|PMID:25774715
Biological Process	GO:0042742	defense response to bacterium	Gbp2	IDA		Mouse	PMID:27693356
Biological Process	GO:0042742	defense response to bacterium	gbp4	IGI	ZFIN:ZDB-GENE-000511-2	Zfish	PMID:27363812
Biological Process	GO:0042742	defense response to bacterium	gbp4	IGI	ZFIN:ZDB-GENE-000616-3	Zfish	PMID:27363812
Biological Process	GO:0042742	defense response to bacterium	gbp4	IMP	ZFIN:ZDB-MRPHLNO-170915-6	Zfish	PMID:27363812
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Gbp2	IDA		Mouse	PMID:18025219
Biological Process	GO:0042832	defense response to protozoan	GBP1	IDA		Human	PMID:31268602
Biological Process	GO:0042832	defense response to protozoan	Gbp2	IDA		Mouse	PMID:18025219
Biological Process	GO:0051607	defense response to virus	GBP2	IDA		Human	PMID:31091448
Biological Process	GO:0045087	innate immune response	GBP1	IDA		Human	PMID:29144452
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GBP1	IMP		Human	PMID:24337748
Biological Process	GO:0032703	negative regulation of interleukin-2 production	GBP1	IMP		Human	PMID:24337748
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	GBP1	IMP		Human	PMID:24337748
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	GBP1	IMP		Human	PMID:24337748
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	GBP1	IMP		Human	PMID:24337748
Biological Process	GO:0001780	neutrophil homeostasis	gbp4	IMP	ZFIN:ZDB-MRPHLNO-170915-6	Zfish	PMID:27363812
Biological Process	GO:0070944	neutrophil-mediated killing of bacterium	gbp4	IMP	ZFIN:ZDB-MRPHLNO-170915-6	Zfish	PMID:27363812
Biological Process	GO:0140973	positive regulation of AIM2 inflammasome complex assembly	Gbp2	IDA		Mouse	MGI:MGI:5774628\|PMID:25774715
Biological Process	GO:0140973	positive regulation of AIM2 inflammasome complex assembly	Gbp2	IDA		Mouse	MGI:MGI:5774627\|PMID:25774716
Biological Process	GO:0140639	positive regulation of pyroptosis	GBP1	IDA		Human	PMID:31268602
Biological Process	GO:0140639	positive regulation of pyroptosis	Gbp2	IDA		Mouse	MGI:MGI:7432484\|PMID:30062052
Biological Process	GO:0140639	positive regulation of pyroptosis	Gbp2	IMP		Mouse	MGI:MGI:5565107\|PMID:24715728
Biological Process	GO:0140639	positive regulation of pyroptosis	Gbp2	IDA		Mouse	MGI:MGI:5774627\|PMID:25774716
Biological Process	GO:0140639	positive regulation of pyroptosis	Gbp2	IDA		Mouse	MGI:MGI:5774628\|PMID:25774715
Biological Process	GO:0034504	protein localization to nucleus	GBP2	IDA		Human	PMID:21151871
Biological Process	GO:0072665	protein localization to vacuole	GBP1	IDA		Human	PMID:21151871
Biological Process	GO:0006605	protein targeting	Gbp2	IDA		Mouse	PMID:27693356
Biological Process	GO:0050848	regulation of calcium-mediated signaling	GBP1	IMP		Human	PMID:24337748
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	GBP1	IGI	UniProtKB:Q01082	Human	PMID:24337748
Biological Process	GO:0009617	response to bacterium	Gbp2	IEP		Mouse	PMID:23012479

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.