Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GBP4,GBP7
  • Mouse genes Gbp3
  • Rat genes Gbp4
  • Zfish genes gbp1,gbp2,gbp3,si:ch211-209n20.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gbp3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	GBP4	IPI	UniProtKB:Q96PP9	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP7	IPI	UniProtKB:Q96AL5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GBP7	IPI	UniProtKB:Q96FN4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GBP4	IPI	UniProtKB:P32455	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP4	IPI	UniProtKB:P32456	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP4	IPI	UniProtKB:Q96PP8	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP4	IPI	UniProtKB:Q9H0R5	Human	PMID:21151871
Molecular Function	GO:0042803	protein homodimerization activity	GBP4	IDA		Human	PMID:21151871
Cellular Component	GO:0031410	cytoplasmic vesicle	Gbp3	IDA		Mouse	PMID:18025219
Cellular Component	GO:0005829	cytosol	GBP4	IDA		Human	PMID:21151871
Cellular Component	GO:0005829	cytosol	Gbp3	IDA		Mouse	PMID:9659399
Cellular Component	GO:0005794	Golgi apparatus	GBP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GBP4	IDA		Human	PMID:17266443
Cellular Component	GO:0005634	nucleus	GBP4	IDA		Human	PMID:21151871
Cellular Component	GO:0048471	perinuclear region of cytoplasm	GBP4	IDA		Human	PMID:17266443
Cellular Component	GO:0005886	plasma membrane	GBP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0020005	symbiont-containing vacuole membrane	Gbp3	IDA		Mouse	PMID:18025219
Biological Process	GO:0002218	activation of innate immune response	Gbp3	IMP		Mouse	MGI:MGI:5571540|PMID:24739961
Biological Process	GO:0044406	adhesion of symbiont to host	Gbp3	IDA		Mouse	PMID:18025219
Biological Process	GO:0035458	cellular response to interferon-beta	Gbp3	IDA		Mouse	MGI:MGI:4412460|PMID:18025219
Biological Process	GO:0035458	cellular response to interferon-beta	Gbp3	IDA		Mouse	PMID:19158679
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Gbp3	IMP		Mouse	MGI:MGI:5565107|PMID:24715728
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Gbp3	IDA		Mouse	MGI:MGI:4412460|PMID:18025219
Biological Process	GO:0071346	cellular response to type II interferon	GBP4	IEP		Human	PMID:17266443
Biological Process	GO:0071346	cellular response to type II interferon	Gbp3	IDA		Mouse	PMID:18025219
Biological Process	GO:0051715	cytolysis in another organism	Gbp3	IMP		Mouse	MGI:MGI:5565107|PMID:24715728
Biological Process	GO:0051715	cytolysis in another organism	Gbp3	IMP		Mouse	MGI:MGI:5571540|PMID:24739961
Biological Process	GO:0042742	defense response to bacterium	Gbp3	IMP		Mouse	MGI:MGI:5571540|PMID:24739961
Biological Process	GO:0042742	defense response to bacterium	Gbp3	IMP		Mouse	MGI:MGI:5565107|PMID:24715728
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Gbp3	IDA		Mouse	PMID:18025219
Biological Process	GO:0042832	defense response to protozoan	Gbp3	IDA		Mouse	PMID:18025219
Biological Process	GO:0051607	defense response to virus	GBP7	IDA		Human	PMID:33408175
Biological Process	GO:0001818	negative regulation of cytokine production	GBP7	IMP		Human	PMID:33408175
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	GBP7	IMP		Human	PMID:33408175
Biological Process	GO:0032480	negative regulation of type I interferon production	GBP7	IMP		Human	PMID:33408175
Biological Process	GO:0034345	negative regulation of type III interferon production	GBP7	IMP		Human	PMID:33408175
Biological Process	GO:0140639	positive regulation of pyroptosis	Gbp3	IMP		Mouse	MGI:MGI:5565107|PMID:24715728
Biological Process	GO:0045070	positive regulation of viral genome replication	GBP7	IMP		Human	PMID:33408175
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GBP7	IMP		Human	PMID:33408175

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern