Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GBP5
  • Mouse genes Gbp5
  • Rat genes Gbp5
  • Zfish genes gbp1,gbp2,gbp3,si:ch211-209n20.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gbp5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003924	GTPase activity	GBP5	IDA		Human	PMID:26996307
Molecular Function	GO:0003924	GTPase activity	GBP5	IDA		Human	PMID:33876762
Molecular Function	GO:0042802	identical protein binding	GBP5	IPI	UniProtKB:Q96PP8	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	GBP5	IPI	UniProtKB:Q96PP8	Human	PMID:20180847
Molecular Function	GO:0042802	identical protein binding	GBP5	IPI	UniProtKB:Q96PP8	Human	PMID:21151871
Molecular Function	GO:0140678	molecular function inhibitor activity	GBP5	IDA		Human	PMID:31091448
Molecular Function	GO:0005515	protein binding	GBP5	IPI	UniProtKB:P32455	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP5	IPI	UniProtKB:P32455|UniProtKB:P32456	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP5	IPI	UniProtKB:P32456	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP5	IPI	UniProtKB:Q96PP9	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP5	IPI	UniProtKB:Q96PP9|UniProtKB:Q9H0R5	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP5	IPI	UniProtKB:Q9H0R5	Human	PMID:21151871
Molecular Function	GO:0005515	protein binding	GBP5	IPI	UniProtKB:Q96P20	Human	PMID:22461501
Molecular Function	GO:0005515	protein binding	GBP5	IPI	UniProtKB:P32455	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Gbp5	IPI	UniProtKB:Q8R4B8	Mouse	MGI:MGI:5319585|PMID:22461501
Molecular Function	GO:0042803	protein homodimerization activity	GBP5	IDA		Human	PMID:21151871
Molecular Function	GO:0042803	protein homodimerization activity	GBP5	IDA		Human	PMID:33876762
Cellular Component	GO:0005737	cytoplasm	GBP5	IDA		Human	PMID:17266443
Cellular Component	GO:0031410	cytoplasmic vesicle	Gbp5	IDA		Mouse	PMID:18025219
Cellular Component	GO:0005794	Golgi apparatus	GBP5	IDA		Human	PMID:26996307
Cellular Component	GO:0005794	Golgi apparatus	GBP5	IDA		Human	PMID:31091448
Cellular Component	GO:0005794	Golgi apparatus	GBP5	IDA		Human	PMID:17266443
Cellular Component	GO:0005794	Golgi apparatus	GBP5	IDA		Human	PMID:21151871
Cellular Component	GO:0000139	Golgi membrane	GBP5	IDA		Human	PMID:31091448
Cellular Component	GO:0016020	membrane	GBP5	HDA		Human	PMID:19946888
Cellular Component	GO:0048471	perinuclear region of cytoplasm	GBP5	IDA		Human	PMID:21151871
Cellular Component	GO:0106139	symbiont cell surface	Gbp5	IDA		Mouse	PMID:27693356
Biological Process	GO:0002218	activation of innate immune response	Gbp5	IMP		Mouse	MGI:MGI:5571540|PMID:24739961
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Gbp5	IMP		Mouse	MGI:MGI:5565107|PMID:24715728
Biological Process	GO:0071346	cellular response to type II interferon	GBP5	IEP		Human	PMID:17266443
Biological Process	GO:0071346	cellular response to type II interferon	Gbp5	IDA		Mouse	PMID:18025219
Biological Process	GO:0051715	cytolysis in another organism	Gbp5	IMP		Mouse	MGI:MGI:5565107|PMID:24715728
Biological Process	GO:0051715	cytolysis in another organism	Gbp5	IMP		Mouse	MGI:MGI:5571540|PMID:24739961
Biological Process	GO:0051715	cytolysis in another organism	Gbp5	IDA		Mouse	MGI:MGI:5774628|PMID:25774715
Biological Process	GO:0051715	cytolysis in another organism	Gbp5	IDA		Mouse	MGI:MGI:7432483|PMID:30589883
Biological Process	GO:0051715	cytolysis in another organism	Gbp5	IDA		Mouse	MGI:MGI:5774627|PMID:25774716
Biological Process	GO:0042742	defense response to bacterium	Gbp5	IMP		Mouse	MGI:MGI:5571540|PMID:24739961
Biological Process	GO:0042742	defense response to bacterium	Gbp5	IMP		Mouse	MGI:MGI:5565107|PMID:24715728
Biological Process	GO:0042742	defense response to bacterium	Gbp5	IDA		Mouse	MGI:MGI:5774628|PMID:25774715
Biological Process	GO:0042742	defense response to bacterium	Gbp5	IDA		Mouse	MGI:MGI:7432483|PMID:30589883
Biological Process	GO:0042742	defense response to bacterium	Gbp5	IDA		Mouse	PMID:27693356
Biological Process	GO:0051607	defense response to virus	GBP5	IDA		Human	PMID:26996307
Biological Process	GO:0051607	defense response to virus	GBP5	IDA		Human	PMID:31091448
Biological Process	GO:0140973	positive regulation of AIM2 inflammasome complex assembly	Gbp5	IDA		Mouse	MGI:MGI:5774627|PMID:25774716
Biological Process	GO:0140973	positive regulation of AIM2 inflammasome complex assembly	Gbp5	IDA		Mouse	MGI:MGI:5774628|PMID:25774715
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Gbp5	IMP		Mouse	MGI:MGI:5319585|PMID:22461501
Biological Process	GO:0045089	positive regulation of innate immune response	Gbp5	IMP		Mouse	MGI:MGI:5319585|PMID:22461501
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	GBP5	IMP		Human	PMID:22461501
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Gbp5	IMP		Mouse	MGI:MGI:5319585|PMID:22461501
Biological Process	GO:0032741	positive regulation of interleukin-18 production	Gbp5	IMP		Mouse	MGI:MGI:5319585|PMID:22461501
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	GBP5	IDA		Human	PMID:22461501
Biological Process	GO:0140639	positive regulation of pyroptosis	Gbp5	IDA		Mouse	MGI:MGI:5774627|PMID:25774716
Biological Process	GO:0140639	positive regulation of pyroptosis	Gbp5	IDA		Mouse	MGI:MGI:5774628|PMID:25774715
Biological Process	GO:0140639	positive regulation of pyroptosis	Gbp5	IMP		Mouse	MGI:MGI:5565107|PMID:24715728
Biological Process	GO:0140639	positive regulation of pyroptosis	Gbp5	IDA		Mouse	MGI:MGI:7432483|PMID:30589883
Biological Process	GO:0051289	protein homotetramerization	GBP5	IDA		Human	PMID:22461501
Biological Process	GO:0034067	protein localization to Golgi apparatus	GBP5	IDA		Human	PMID:21151871
Biological Process	GO:0006605	protein targeting	Gbp5	IDA		Mouse	PMID:27693356
Biological Process	GO:0009617	response to bacterium	Gbp5	IEP		Mouse	PMID:23012479

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern