Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GCG
  • Mouse genes Gcg
  • Rat genes Gcg
  • Zfish genes gcga,gcgb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gcg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031769	glucagon receptor binding	Gcg	IDA		Rat	PMID:12960094|RGD:1627653
Molecular Function	GO:0031769	glucagon receptor binding	gcga	IDA		Zfish	ZFIN:ZDB-PUB-041015-1
Molecular Function	GO:0031769	glucagon receptor binding	gcga	IDA		Zfish	PMID:19793957
Molecular Function	GO:0005179	hormone activity	Gcg	IMP		Rat	PMID:11557638|RGD:2315021
Molecular Function	GO:0005179	hormone activity	Gcg	IDA		Rat	PMID:12960094|RGD:1627653
Molecular Function	GO:0042802	identical protein binding	GCG	IPI	UniProtKB:P01275	Human	PMID:22212535
Molecular Function	GO:0005515	protein binding	GCG	IPI	UniProtKB:P14735-1	Human	PMID:17051221
Molecular Function	GO:0005515	protein binding	GCG	IPI	UniProtKB:P48546	Human	PMID:17715056
Molecular Function	GO:0005515	protein binding	GCG	IPI	UniProtKB:P27487	Human	PMID:21314817
Molecular Function	GO:0005515	protein binding	GCG	IPI	UniProtKB:Q12884	Human	PMID:21314817
Molecular Function	GO:0048018	receptor ligand activity	Gcg	IDA		Mouse	PMID:30380405
Cellular Component	GO:0005737	cytoplasm	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Cellular Component	GO:0005737	cytoplasm	Gcg	IDA		Mouse	MGI:MGI:4889014|PMID:21234744
Cellular Component	GO:0005737	cytoplasm	Gcg	IDA		Mouse	PMID:17928203
Cellular Component	GO:0005615	extracellular space	Gcg	IDA		Mouse	MGI:MGI:5304221|PMID:22037645
Cellular Component	GO:0005615	extracellular space	Gcg	IDA		Mouse	PMID:17693256
Cellular Component	GO:0005615	extracellular space	Gcg	IDA		Rat	PMID:12876072|RGD:1625268
Cellular Component	GO:0005615	extracellular space	Gcg	IDA		Rat	PMID:29504286|RGD:152995491
Cellular Component	GO:0005886	plasma membrane	Gcg	IDA		Mouse	PMID:30380405
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	Gcg	IDA		Rat	PMID:12960094|RGD:1627653
Biological Process	GO:0071377	cellular response to glucagon stimulus	Gcg	IDA		Mouse	PMID:30380405
Biological Process	GO:0006094	gluconeogenesis	Gcg	IDA		Mouse	PMID:24051374
Biological Process	GO:0042593	glucose homeostasis	Gcg	IDA		Mouse	MGI:MGI:5304221|PMID:22037645
Biological Process	GO:0043066	negative regulation of apoptotic process	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0032099	negative regulation of appetite	Gcg	IMP		Rat	PMID:11557638|RGD:2315021
Biological Process	GO:1900118	negative regulation of execution phase of apoptosis	Gcg	IDA		Mouse	PMID:19915011
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0090280	positive regulation of calcium ion import	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Gcg	IDA		Mouse	PMID:24051374
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	Gcg	IGI	MGI:MGI:1918367	Mouse	PMID:24051374
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	Gcg	IGI	MGI:MGI:2155884	Mouse	PMID:24051374
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	Gcg	IGI	MGI:MGI:1344416	Mouse	PMID:24051374
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0032092	positive regulation of protein binding	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0045860	positive regulation of protein kinase activity	Gcg	IDA		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0010737	protein kinase A signaling	Gcg	IMP		Mouse	MGI:MGI:4453294|PMID:19915011
Biological Process	GO:0050796	regulation of insulin secretion	Gcg	IDA		Mouse	MGI:MGI:5304221|PMID:22037645
Biological Process	GO:0050796	regulation of insulin secretion	Gcg	IDA		Mouse	PMID:14736883
Biological Process	GO:0014823	response to activity	Gcg	IDA		Mouse	MGI:MGI:5304221|PMID:22037645
Biological Process	GO:1903576	response to L-arginine	Gcg	IEP		Rat	PMID:2182011|RGD:10402368
Biological Process	GO:0042594	response to starvation	gcga	IDA		Zfish	PMID:19793957
Biological Process	GO:0003323	type B pancreatic cell development	gcga	IMP	ZFIN:ZDB-MRPHLNO-150529-3	Zfish	PMID:25852199

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern