Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gck

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GCK
- Mouse genes Gck
- Rat genes Gck
- Zfish genes gck
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gck

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	Gck	IDA		Rat	PMID:12513690\|RGD:2301923
Molecular Function	GO:0005524	ATP binding	GCK	IDA		Human	PMID:12941786
Molecular Function	GO:0005524	ATP binding	GCK	IDA		Human	PMID:16173921
Molecular Function	GO:0005524	ATP binding	GCK	IDA		Human	PMID:8446612
Molecular Function	GO:0005524	ATP binding	Gck	IDA		Rat	PMID:12513690\|RGD:2301923
Molecular Function	GO:0008865	fructokinase activity	Gck	IDA		Rat	PMID:6477520\|RGD:14695079
Molecular Function	GO:0008865	fructokinase activity	Gck	IDA		Rat	PMID:7742312\|RGD:14695076
Molecular Function	GO:0004340	glucokinase activity	GCK	IDA		Human	PMID:12941786
Molecular Function	GO:0004340	glucokinase activity	GCK	IDA		Human	PMID:16173921
Molecular Function	GO:0004340	glucokinase activity	GCK	IMP		Human	PMID:18322640
Molecular Function	GO:0004340	glucokinase activity	GCK	IMP		Human	PMID:19146401
Molecular Function	GO:0004340	glucokinase activity	GCK	IDA		Human	PMID:22611063
Molecular Function	GO:0004340	glucokinase activity	GCK	IDA		Human	PMID:8446612
Molecular Function	GO:0004340	glucokinase activity	Gck	IMP		Mouse	MGI:MGI:5446093\|PMID:22698525
Molecular Function	GO:0004340	glucokinase activity	Gck	IMP		Mouse	MGI:MGI:6377940\|PMID:30146176
Molecular Function	GO:0004340	glucokinase activity	Gck	IMP	MGI:MGI:1861929	Mouse	PMID:7665557
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Mouse	PMID:3931624
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Mouse	PMID:10713097
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Mouse	PMID:9873043
Molecular Function	GO:0004340	glucokinase activity	Gck	IMP	MGI:MGI:1861929	Mouse	PMID:9357804
Molecular Function	GO:0004340	glucokinase activity	Gck	IMP		Mouse	PMID:7510884
Molecular Function	GO:0004340	glucokinase activity	Gck	IMP		Mouse	PMID:7556622
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Mouse	PMID:141272
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Rat	PMID:11250924\|RGD:628440
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Rat	PMID:12513690\|RGD:2301923
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Rat	PMID:15138155\|RGD:1582633
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Rat	PMID:4273555\|RGD:2302790
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Rat	PMID:4353083\|RGD:2302851
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Rat	PMID:6477520\|RGD:14695079
Molecular Function	GO:0004340	glucokinase activity	Gck	IDA		Rat	PMID:7742312\|RGD:14695076
Molecular Function	GO:0005536	glucose binding	GCK	IDA		Human	PMID:12941786
Molecular Function	GO:0005536	glucose binding	GCK	IDA		Human	PMID:16173921
Molecular Function	GO:0005536	glucose binding	GCK	IDA		Human	PMID:8446612
Molecular Function	GO:0005536	glucose binding	Gck	IPI	CHEBI:14314	Rat	PMID:12513690\|RGD:2301923
Molecular Function	GO:0005536	glucose binding	Gck	IPI	CHEBI:17234	Rat	PMID:12513690\|RGD:2301923
Molecular Function	GO:0005536	glucose binding	Gck	IDA		Rat	PMID:15138155\|RGD:1582633
Molecular Function	GO:0005536	glucose binding	Gck	IDA		Rat	PMID:4273555\|RGD:2302790
Molecular Function	GO:0004396	hexokinase activity	Gck	IDA		Mouse	MGI:MGI:77846\|PMID:8530440
Molecular Function	GO:0004396	hexokinase activity	Gck	IMP		Mouse	MGI:MGI:5619737\|PMID:23085254
Molecular Function	GO:0000287	magnesium ion binding	Gck	IDA		Rat	PMID:12513690\|RGD:2301923
Molecular Function	GO:0019158	mannokinase activity	Gck	IDA		Rat	PMID:7742312\|RGD:14695076
Molecular Function	GO:0005515	protein binding	GCK	IPI	UniProtKB:P16118	Human	PMID:11522786
Molecular Function	GO:0005515	protein binding	GCK	IPI	UniProtKB:Q14397	Human	PMID:11522786
Molecular Function	GO:0005515	protein binding	GCK	IPI	UniProtKB:Q07071	Human	PMID:16173921
Molecular Function	GO:0005515	protein binding	GCK	IPI	UniProtKB:A6NLX3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GCK	IPI	UniProtKB:Q14397	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Gck	IPI	UniProtKB:Q61337	Mouse	MGI:MGI:3778846\|PMID:18223655
Molecular Function	GO:0005515	protein binding	Gck	IPI	PR:P63087	Mouse	PMID:12931191
Molecular Function	GO:0005515	protein binding	Gck	IPI	PR:P05132	Mouse	PMID:12931191
Molecular Function	GO:0005515	protein binding	Gck	IPI	PR:Q61337	Mouse	PMID:12931191
Molecular Function	GO:0005515	protein binding	Gck	IPI	PR:Q99N20	Mouse	PMID:12931191
Molecular Function	GO:0005515	protein binding	Gck	IPI	UniProtKB:Q07071	Rat	PMID:10601273\|RGD:8554356
Molecular Function	GO:0005515	protein binding	Gck	IPI	RGD:2671	Rat	PMID:16186382\|RGD:1581880
Molecular Function	GO:0005515	protein binding	Gck	IPI	UniProtKB:Q07071	Rat	PMID:19807849\|RGD:8554135
Molecular Function	GO:0019903	protein phosphatase binding	Gck	IPI	RGD:68375	Rat	PMID:10913113\|RGD:68242
Cellular Component	GO:0005884	actin filament	Gck	IDA		Rat	PMID:9109397\|RGD:2301953
Cellular Component	GO:0045180	basal cortex	Gck	IDA		Rat	PMID:10071239\|RGD:2301948
Cellular Component	GO:0005938	cell cortex	Gck	IDA		Rat	PMID:12369705\|RGD:2301912
Cellular Component	GO:0005737	cytoplasm	Gck	IDA		Rat	PMID:10601273\|RGD:8554356
Cellular Component	GO:0005737	cytoplasm	Gck	IDA		Rat	PMID:15138155\|RGD:1582633
Cellular Component	GO:0005737	cytoplasm	Gck	IDA		Rat	PMID:17028192\|RGD:1581879
Cellular Component	GO:0005737	cytoplasm	Gck	IDA		Rat	PMID:17553851\|RGD:2301905
Cellular Component	GO:0005829	cytosol	GCK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Gck	IDA		Mouse	PMID:24187134
Cellular Component	GO:0005829	cytosol	Gck	IDA		Rat	PMID:16542652\|RGD:1626614
Cellular Component	GO:0005739	mitochondrion	Gck	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Gck	IDA		Mouse	PMID:12931191
Cellular Component	GO:0005739	mitochondrion	Gck	IDA		Rat	PMID:16542652\|RGD:1626614
Cellular Component	GO:0005654	nucleoplasm	Gck	IDA		Rat	PMID:12369705\|RGD:2301912
Cellular Component	GO:0005634	nucleus	Gck	IDA		Mouse	MGI:MGI:1354534\|PMID:10713097
Cellular Component	GO:0005634	nucleus	Gck	IDA		Mouse	PMID:24187134
Cellular Component	GO:0005634	nucleus	Gck	IDA		Rat	PMID:10601273\|RGD:8554356
Cellular Component	GO:0005634	nucleus	Gck	IDA		Rat	PMID:15138155\|RGD:1582633
Cellular Component	GO:0005634	nucleus	Gck	IDA		Rat	PMID:16186382\|RGD:1581880
Cellular Component	GO:0005634	nucleus	Gck	IDA		Rat	PMID:17028192\|RGD:1581879
Cellular Component	GO:0005634	nucleus	Gck	IDA		Rat	PMID:17553851\|RGD:2301905
Cellular Component	GO:0030141	secretory granule	Gck	IDA		Rat	PMID:10461810\|RGD:2301947
Cellular Component	GO:0030141	secretory granule	Gck	IDA		Rat	PMID:9357983\|RGD:2301951
Biological Process	GO:0070509	calcium ion import	Gck	IMP		Mouse	MGI:MGI:3819280\|PMID:18477811
Biological Process	GO:0046835	carbohydrate phosphorylation	Gck	IMP		Mouse	MGI:MGI:3630095\|PMID:7510884
Biological Process	GO:0046835	carbohydrate phosphorylation	Gck	IDA		Mouse	PMID:3931624
Biological Process	GO:0046835	carbohydrate phosphorylation	Gck	IDA		Mouse	PMID:141272
Biological Process	GO:0046835	carbohydrate phosphorylation	Gck	IMP	MGI:MGI:1861929	Mouse	PMID:7665557
Biological Process	GO:0046835	carbohydrate phosphorylation	Gck	IMP		Mouse	PMID:7556622
Biological Process	GO:0046835	carbohydrate phosphorylation	Gck	IDA		Rat	PMID:15138155\|RGD:1582633
Biological Process	GO:0046835	carbohydrate phosphorylation	Gck	IDA		Rat	PMID:9109397\|RGD:2301953
Biological Process	GO:0042149	cellular response to glucose starvation	Gck	IMP		Rat	PMID:18292346\|RGD:2301900
Biological Process	GO:0032869	cellular response to insulin stimulus	Gck	IDA		Rat	PMID:17470517\|RGD:8554539
Biological Process	GO:0044320	cellular response to leptin stimulus	Gck	IDA		Rat	PMID:17470517\|RGD:8554539
Biological Process	GO:0051594	detection of glucose	Gck	IDA		Rat	PMID:17470517\|RGD:8554539
Biological Process	GO:0031018	endocrine pancreas development	gck	IMP	ZFIN:ZDB-MRPHLNO-160621-24	Zfish	PMID:26963759
Biological Process	GO:0006003	fructose 2,6-bisphosphate metabolic process	Gck	IDA		Rat	PMID:17553851\|RGD:2301905
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Gck	IDA		Rat	PMID:6477520\|RGD:14695079
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Gck	IDA		Rat	PMID:7742312\|RGD:14695076
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	GCK	IMP		Human	PMID:18322640
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	GCK	IMP		Human	PMID:19146401
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	Gck	IMP		Mouse	MGI:MGI:3630095\|PMID:7510884
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	Gck	IDA		Rat	PMID:15138155\|RGD:1582633
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	Gck	IDA		Rat	PMID:4273555\|RGD:2302790
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	Gck	IDA		Rat	PMID:6477520\|RGD:14695079
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	Gck	IDA		Rat	PMID:7742312\|RGD:14695076
Biological Process	GO:0006007	glucose catabolic process	GCK	IMP		Human	PMID:12941786
Biological Process	GO:0042593	glucose homeostasis	GCK	IMP		Human	PMID:20668700
Biological Process	GO:0042593	glucose homeostasis	GCK	IMP		Human	PMID:8132752
Biological Process	GO:0042593	glucose homeostasis	Gck	IMP		Mouse	MGI:MGI:3819280\|PMID:18477811
Biological Process	GO:0042593	glucose homeostasis	Gck	IMP	MGI:MGI:1861929	Mouse	PMID:9357804
Biological Process	GO:0042593	glucose homeostasis	Gck	IMP	MGI:MGI:2177710	Mouse	PMID:9867845
Biological Process	GO:0042593	glucose homeostasis	Gck	IMP		Mouse	PMID:7556622
Biological Process	GO:0042593	glucose homeostasis	Gck	IMP	MGI:MGI:2177703	Mouse	PMID:8530440
Biological Process	GO:0042593	glucose homeostasis	Gck	IMP		Rat	PMID:18292346\|RGD:2301900
Biological Process	GO:0042593	glucose homeostasis	gck	IMP	ZFIN:ZDB-MRPHLNO-160621-24	Zfish	PMID:26963759
Biological Process	GO:0006006	glucose metabolic process	Gck	IDA		Mouse	PMID:3931624
Biological Process	GO:0006006	glucose metabolic process	Gck	IMP	MGI:MGI:1861929	Mouse	PMID:9357804
Biological Process	GO:0006006	glucose metabolic process	Gck	IMP	MGI:MGI:1861929	Mouse	PMID:7665557
Biological Process	GO:0006006	glucose metabolic process	Gck	IMP		Mouse	PMID:7556622
Biological Process	GO:0006006	glucose metabolic process	Gck	IDA		Mouse	PMID:141272
Biological Process	GO:0006006	glucose metabolic process	Gck	IDA		Rat	PMID:17553851\|RGD:2301905
Biological Process	GO:0005978	glycogen biosynthetic process	Gck	IDA		Rat	PMID:17028192\|RGD:1581879
Biological Process	GO:0006096	glycolytic process	Gck	IDA		Rat	PMID:4273555\|RGD:2302790
Biological Process	GO:0006096	glycolytic process	Gck	IDA		Rat	PMID:4353083\|RGD:2302851
Biological Process	GO:0001678	intracellular glucose homeostasis	Gck	IMP		Mouse	MGI:MGI:77846\|PMID:8530440
Biological Process	GO:0001678	intracellular glucose homeostasis	Gck	IMP	MGI:MGI:1857469	Mouse	PMID:7553875
Biological Process	GO:0001678	intracellular glucose homeostasis	Gck	IMP		Rat	PMID:16443775\|RGD:1601297
Biological Process	GO:0055088	lipid homeostasis	Gck	IDA		Rat	PMID:22925001\|RGD:7488945
Biological Process	GO:0006013	mannose metabolic process	Gck	IDA		Rat	PMID:7742312\|RGD:14695076
Biological Process	GO:0006739	NADP metabolic process	Gck	IMP		Mouse	PMID:9873043
Biological Process	GO:0032811	negative regulation of epinephrine secretion	Gck	IMP		Rat	PMID:18292346\|RGD:2301900
Biological Process	GO:0045721	negative regulation of gluconeogenesis	GCK	IMP		Human	PMID:8878425
Biological Process	GO:1990798	pancreas regeneration	gck	IMP	ZFIN:ZDB-MRPHLNO-160621-24	Zfish	PMID:26963759
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Gck	IDA		Rat	PMID:17360975\|RGD:2301916
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	GCK	IMP		Human	PMID:8878425
Biological Process	GO:0045821	positive regulation of glycolytic process	Gck	IDA		Rat	PMID:17553851\|RGD:2301905
Biological Process	GO:0032024	positive regulation of insulin secretion	GCK	IMP		Human	PMID:8132752
Biological Process	GO:0032024	positive regulation of insulin secretion	GCK	IMP		Human	PMID:8878425
Biological Process	GO:0032024	positive regulation of insulin secretion	Gck	IMP		Mouse	MGI:MGI:3819280\|PMID:18477811
Biological Process	GO:0032024	positive regulation of insulin secretion	Gck	IMP		Mouse	PMID:7556622
Biological Process	GO:0032024	positive regulation of insulin secretion	Gck	IDA		Rat	PMID:17028192\|RGD:1581879
Biological Process	GO:0032024	positive regulation of insulin secretion	Gck	IDA		Rat	PMID:17360975\|RGD:2301916
Biological Process	GO:0042327	positive regulation of phosphorylation	Gck	IDA		Rat	PMID:17553851\|RGD:2301905
Biological Process	GO:1902659	regulation of glucose mediated signaling pathway	Gck	IMP		Rat	PMID:16443775\|RGD:1601297
Biological Process	GO:0050796	regulation of insulin secretion	GCK	IMP		Human	PMID:20668700
Biological Process	GO:0050796	regulation of insulin secretion	Gck	IMP	MGI:MGI:2177703	Mouse	PMID:8954920
Biological Process	GO:0050796	regulation of insulin secretion	Gck	IMP	MGI:MGI:2177703	Mouse	PMID:8530440
Biological Process	GO:0043266	regulation of potassium ion transport	Gck	IMP	MGI:MGI:2177703	Mouse	PMID:9662046
Biological Process	GO:0009749	response to glucose	Gck	IEP		Rat	PMID:12086933\|RGD:728812
Biological Process	GO:0019932	second-messenger-mediated signaling	Gck	IDA		Rat	PMID:11250924\|RGD:628440
Biological Process	GO:0003323	type B pancreatic cell development	gck	IMP	ZFIN:ZDB-MRPHLNO-160621-24	Zfish	PMID:26963759

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.