Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GCKR
  • Mouse genes Gckr
  • Rat genes Gckr
  • Zfish genes gckr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gckr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030246	carbohydrate binding	Gckr	IMP		Rat	PMID:11756407|RGD:1300209
Molecular Function	GO:0030246	carbohydrate binding	Gckr	IDA		Rat	PMID:14627435|RGD:1598592
Molecular Function	GO:0019899	enzyme binding	Gckr	IMP		Rat	PMID:11756407|RGD:1300209
Molecular Function	GO:0019899	enzyme binding	Gckr	IPI	RGD:2670	Rat	PMID:16186382|RGD:1581880
Molecular Function	GO:0004857	enzyme inhibitor activity	Gckr	IDA		Rat	PMID:11756407|RGD:1300209
Molecular Function	GO:0004857	enzyme inhibitor activity	Gckr	IDA		Rat	PMID:14627435|RGD:1598592
Molecular Function	GO:0070095	fructose-6-phosphate binding	GCKR	IDA		Human	PMID:14627435
Molecular Function	GO:0070095	fructose-6-phosphate binding	GCKR	IDA		Human	PMID:23621087
Molecular Function	GO:0005515	protein binding	GCKR	IPI	UniProtKB:P35557	Human	PMID:11522786
Molecular Function	GO:0005515	protein binding	GCKR	IPI	UniProtKB:P35557	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Gckr	IPI	UniProtKB:P17712	Rat	PMID:10601273|RGD:8554356
Molecular Function	GO:0005515	protein binding	Gckr	IPI	UniProtKB:P35557	Rat	PMID:16173921|RGD:8553543
Molecular Function	GO:0005515	protein binding	Gckr	IPI	UniProtKB:P17712	Rat	PMID:19807849|RGD:8554135
Molecular Function	GO:0019904	protein domain specific binding	Gckr	IPI	RGD:2670	Rat	PMID:16186382|RGD:1581880
Cellular Component	GO:0005737	cytoplasm	Gckr	IDA		Rat	PMID:10518020|RGD:8554213
Cellular Component	GO:0005737	cytoplasm	Gckr	IDA		Rat	PMID:10601273|RGD:8554356
Cellular Component	GO:0005737	cytoplasm	Gckr	IDA		Rat	PMID:15138155|RGD:1582633
Cellular Component	GO:0005829	cytosol	Gckr	IDA		Rat	PMID:16542652|RGD:1626614
Cellular Component	GO:0005739	mitochondrion	Gckr	IDA		Rat	PMID:16542652|RGD:1626614
Cellular Component	GO:0005654	nucleoplasm	Gckr	IDA		Rat	PMID:10518020|RGD:8554213
Cellular Component	GO:0005634	nucleus	Gckr	IDA		Mouse	MGI:MGI:1354534|PMID:10713097
Cellular Component	GO:0005634	nucleus	Gckr	IDA		Mouse	PMID:10588736
Cellular Component	GO:0005634	nucleus	Gckr	IDA		Rat	PMID:10601273|RGD:8554356
Cellular Component	GO:0005634	nucleus	Gckr	IDA		Rat	PMID:15138155|RGD:1582633
Cellular Component	GO:0005634	nucleus	Gckr	IDA		Rat	PMID:16186382|RGD:1581880
Biological Process	GO:0031018	endocrine pancreas development	gckr	IMP	ZFIN:ZDB-MRPHLNO-160621-25	Zfish	PMID:26963759
Biological Process	GO:0042593	glucose homeostasis	gckr	IMP	ZFIN:ZDB-MRPHLNO-160621-25	Zfish	PMID:26963759
Biological Process	GO:0001678	intracellular glucose homeostasis	Gckr	IMP	MGI:MGI:2384075	Mouse	PMID:10588736
Biological Process	GO:0033132	negative regulation of glucokinase activity	GCKR	IDA		Human	PMID:14627435
Biological Process	GO:0033132	negative regulation of glucokinase activity	GCKR	IDA		Human	PMID:23621087
Biological Process	GO:0033132	negative regulation of glucokinase activity	Gckr	IMP	MGI:MGI:2386670	Mouse	PMID:10713097
Biological Process	GO:0033132	negative regulation of glucokinase activity	Gckr	IDA		Rat	PMID:14627435|RGD:1598592
Biological Process	GO:1903300	negative regulation of hexokinase activity	Gckr	IDA		Rat	PMID:14627435|RGD:1598592
Biological Process	GO:1990798	pancreas regeneration	gckr	IMP	ZFIN:ZDB-MRPHLNO-160621-25	Zfish	PMID:26963759
Biological Process	GO:0033133	positive regulation of glucokinase activity	Gckr	IMP		Mouse	MGI:MGI:1354534|PMID:10713097
Biological Process	GO:0006606	protein import into nucleus	Gckr	IMP	MGI:MGI:2384075	Mouse	PMID:10588736
Biological Process	GO:0006606	protein import into nucleus	Gckr	IDA		Rat	PMID:10601273|RGD:8554356
Biological Process	GO:0034504	protein localization to nucleus	Gckr	IMP		Mouse	PMID:10713097
Biological Process	GO:0009750	response to fructose	GCKR	IDA		Human	PMID:14627435
Biological Process	GO:0009750	response to fructose	Gckr	IDA		Rat	PMID:14627435|RGD:1598592
Biological Process	GO:0070328	triglyceride homeostasis	GCKR	IMP		Human	PMID:19526250
Biological Process	GO:0070328	triglyceride homeostasis	GCKR	IMP		Human	PMID:20668700
Biological Process	GO:0046415	urate metabolic process	GCKR	IMP		Human	PMID:19503597

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern