Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gclc

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GCLC
- Mouse genes Gclc
- Rat genes Gclc
- Zfish genes gclc
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gclc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	GCLC	IDA		Human	PMID:24639
Molecular Function	GO:0016595	glutamate binding	GCLC	IDA		Human	PMID:9841880
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	GCLC	IDA		Human	PMID:11972604
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	GCLC	IMP		Human	PMID:12663448
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	GCLC	IMP		Human	PMID:16183645
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	GCLC	IDA		Human	PMID:8104187
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	GCLC	IDA		Human	PMID:9675072
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	GCLC	IMP		Human	PMID:9841880
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	Gclc	IMP	MGI:MGI:2429419	Mouse	PMID:11118286
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	Gclc	IDA		Mouse	PMID:16081425
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	Gclc	IDA		Mouse	PMID:12384496
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	Gclc	IDA		Mouse	PMID:15288121
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	Gclc	IDA		Mouse	PMID:10966520
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	Gclc	IDA		Rat	PMID:12425961\|RGD:11049538
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	Gclc	IMP		Rat	PMID:16183645\|RGD:1582661
Molecular Function	GO:0000287	magnesium ion binding	GCLC	IDA		Human	PMID:24639
Molecular Function	GO:0005515	protein binding	GCLC	IPI	UniProtKB:P48507	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	GCLC	IPI	UniProtKB:P48507	Human	PMID:9675072
Molecular Function	GO:0005515	protein binding	GCLC	IPI	UniProtKB:P48507	Human	PMID:9841880
Molecular Function	GO:0005515	protein binding	Gclc	IPI	PR:O09172	Mouse	PMID:12384496
Molecular Function	GO:0005515	protein binding	Gclc	IPI	PR:O09172	Mouse	PMID:16081425
Molecular Function	GO:0044877	protein-containing complex binding	Gclc	IDA		Rat	PMID:16137247\|RGD:1582663
Cellular Component	GO:0005829	cytosol	Gclc	IDA		Mouse	PMID:12384496
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	GCLC	IDA		Human	PMID:9675072
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	GCLC	IDA		Human	PMID:9841880
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	Gclc	IDA		Mouse	PMID:12384496
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	Gclc	IDA		Rat	PMID:16137247\|RGD:1582663
Biological Process	GO:0007568	aging	Gclc	IEP		Rat	PMID:20018823\|RGD:10402378
Biological Process	GO:0097746	blood vessel diameter maintenance	GCLC	IMP		Human	PMID:12598062
Biological Process	GO:0045454	cell redox homeostasis	GCLC	IDA		Human	PMID:10439045
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Gclc	IEP		Rat	PMID:18042181\|RGD:10402377
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Gclc	IEP		Rat	PMID:18042181\|RGD:10402377
Biological Process	GO:0071333	cellular response to glucose stimulus	Gclc	IEP		Rat	PMID:20466058\|RGD:10402379
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	Gclc	IEP		Rat	PMID:20466058\|RGD:10402379
Biological Process	GO:0032869	cellular response to insulin stimulus	Gclc	IEP		Rat	PMID:15169830\|RGD:10402381
Biological Process	GO:0071260	cellular response to mechanical stimulus	Gclc	IEP		Rat	PMID:20054150\|RGD:8547898
Biological Process	GO:0097069	cellular response to thyroxine stimulus	Gclc	IEP		Rat	PMID:17291985\|RGD:10402376
Biological Process	GO:0006534	cysteine metabolic process	GCLC	IDA		Human	PMID:2294991
Biological Process	GO:0006536	glutamate metabolic process	GCLC	IDA		Human	PMID:12663448
Biological Process	GO:0006536	glutamate metabolic process	GCLC	IDA		Human	PMID:2294991
Biological Process	GO:0006536	glutamate metabolic process	GCLC	IDA		Human	PMID:9841880
Biological Process	GO:0006750	glutathione biosynthetic process	GCLC	IDA		Human	PMID:10395918
Biological Process	GO:0006750	glutathione biosynthetic process	GCLC	IMP		Human	PMID:12663448
Biological Process	GO:0006750	glutathione biosynthetic process	GCLC	IDA		Human	PMID:8104187
Biological Process	GO:0006750	glutathione biosynthetic process	GCLC	IDA		Human	PMID:9675072
Biological Process	GO:0006750	glutathione biosynthetic process	Gclc	IMP	MGI:MGI:2387010	Mouse	PMID:10805773
Biological Process	GO:0006750	glutathione biosynthetic process	Gclc	IDA		Mouse	PMID:16081425
Biological Process	GO:0006750	glutathione biosynthetic process	Gclc	IMP		Rat	PMID:16183645\|RGD:1582661
Biological Process	GO:0006749	glutathione metabolic process	Gclc	IMP	MGI:MGI:2429419	Mouse	PMID:11118286
Biological Process	GO:0019852	L-ascorbic acid metabolic process	Gclc	IMP	MGI:MGI:2429419	Mouse	PMID:11118286
Biological Process	GO:0043066	negative regulation of apoptotic process	GCLC	IDA		Human	PMID:10439045
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	GCLC	IDA		Human	PMID:10439045
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Gclc	IGI	MGI:MGI:104995	Mouse	PMID:15288121
Biological Process	GO:2000490	negative regulation of hepatic stellate cell activation	Gclc	IMP		Rat	PMID:22942279\|RGD:11049542
Biological Process	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Gclc	IGI	MGI:MGI:104995	Mouse	PMID:15288121
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Gclc	IMP		Rat	PMID:16183645\|RGD:1582661
Biological Process	GO:0031397	negative regulation of protein ubiquitination	Gclc	IMP	MGI:MGI:2387010	Mouse	PMID:17189825
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Gclc	IMP	MGI:MGI:2387010	Mouse	PMID:17189825
Biological Process	GO:0051900	regulation of mitochondrial depolarization	Gclc	IGI	MGI:MGI:104995	Mouse	PMID:15288121
Biological Process	GO:0014823	response to activity	Gclc	IEP		Rat	PMID:20018823\|RGD:10402378
Biological Process	GO:0046685	response to arsenic-containing substance	Gclc	IMP	MGI:MGI:2387010	Mouse	PMID:17189825
Biological Process	GO:0046686	response to cadmium ion	Gclc	IEP		Rat	PMID:10702364\|RGD:10402382
Biological Process	GO:0009408	response to heat	GCLC	IDA		Human	PMID:8104187
Biological Process	GO:0009725	response to hormone	GCLC	IDA		Human	PMID:8104187
Biological Process	GO:0044752	response to human chorionic gonadotropin	Gclc	IEP		Rat	PMID:15811874\|RGD:10402375
Biological Process	GO:0070555	response to interleukin-1	Gclc	IEP		Rat	PMID:15485876\|RGD:10402384
Biological Process	GO:0051409	response to nitrosative stress	Gclc	IMP		Rat	PMID:16183645\|RGD:1582661
Biological Process	GO:0007584	response to nutrient	Gclc	IEP		Rat	PMID:22906634\|RGD:11049541
Biological Process	GO:0006979	response to oxidative stress	GCLC	IDA		Human	PMID:10395918
Biological Process	GO:0006979	response to oxidative stress	GCLC	IDA		Human	PMID:11972604
Biological Process	GO:0006979	response to oxidative stress	Gclc	IMP		Rat	PMID:16183645\|RGD:1582661
Biological Process	GO:0009410	response to xenobiotic stimulus	Gclc	IMP	MGI:MGI:2387010	Mouse	PMID:17189825

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.