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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gclc

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gclc
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0043531ADP bindingGCLCIDAHumanPMID:24639
Molecular FunctionGO:0016595glutamate bindingGCLCIDAHumanPMID:9841880
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGCLCIDAHumanPMID:11972604
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGCLCIMPHumanPMID:12663448
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGCLCIMPHumanPMID:16183645
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGCLCIDAHumanPMID:8104187
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGCLCIDAHumanPMID:9675072
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGCLCIMPHumanPMID:9841880
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGclcIMPMGI:MGI:2429419MousePMID:11118286
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGclcIDAMousePMID:16081425
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGclcIDAMousePMID:12384496
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGclcIDAMousePMID:15288121
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGclcIDAMousePMID:10966520
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGclcIDARatPMID:12425961|RGD:11049538
Molecular FunctionGO:0004357glutamate-cysteine ligase activityGclcIMPRatPMID:16183645|RGD:1582661
Molecular FunctionGO:0000287magnesium ion bindingGCLCIDAHumanPMID:24639
Molecular FunctionGO:0005515protein bindingGCLCIPIUniProtKB:P48507HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingGCLCIPIUniProtKB:P48507HumanPMID:9675072
Molecular FunctionGO:0005515protein bindingGCLCIPIUniProtKB:P48507HumanPMID:9841880
Molecular FunctionGO:0005515protein bindingGclcIPIPR:O09172MousePMID:12384496
Molecular FunctionGO:0005515protein bindingGclcIPIPR:O09172MousePMID:16081425
Molecular FunctionGO:0044877protein-containing complex bindingGclcIDARatPMID:16137247|RGD:1582663
Cellular ComponentGO:0005829cytosolGclcIDAMousePMID:12384496
Cellular ComponentGO:0017109glutamate-cysteine ligase complexGCLCIDAHumanPMID:9675072
Cellular ComponentGO:0017109glutamate-cysteine ligase complexGCLCIDAHumanPMID:9841880
Cellular ComponentGO:0017109glutamate-cysteine ligase complexGclcIDAMousePMID:12384496
Cellular ComponentGO:0017109glutamate-cysteine ligase complexGclcIDARatPMID:16137247|RGD:1582663
Biological ProcessGO:0007568agingGclcIEPRatPMID:20018823|RGD:10402378
Biological ProcessGO:0097746blood vessel diameter maintenanceGCLCIMPHumanPMID:12598062
Biological ProcessGO:0045454cell redox homeostasisGCLCIDAHumanPMID:10439045
Biological ProcessGO:0044344cellular response to fibroblast growth factor stimulusGclcIEPRatPMID:18042181|RGD:10402377
Biological ProcessGO:0071372cellular response to follicle-stimulating hormone stimulusGclcIEPRatPMID:18042181|RGD:10402377
Biological ProcessGO:0071333cellular response to glucose stimulusGclcIEPRatPMID:20466058|RGD:10402379
Biological ProcessGO:0035729cellular response to hepatocyte growth factor stimulusGclcIEPRatPMID:20466058|RGD:10402379
Biological ProcessGO:0032869cellular response to insulin stimulusGclcIEPRatPMID:15169830|RGD:10402381
Biological ProcessGO:0071260cellular response to mechanical stimulusGclcIEPRatPMID:20054150|RGD:8547898
Biological ProcessGO:0097069cellular response to thyroxine stimulusGclcIEPRatPMID:17291985|RGD:10402376
Biological ProcessGO:0006534cysteine metabolic processGCLCIDAHumanPMID:2294991
Biological ProcessGO:0006536glutamate metabolic processGCLCIDAHumanPMID:12663448
Biological ProcessGO:0006536glutamate metabolic processGCLCIDAHumanPMID:2294991
Biological ProcessGO:0006536glutamate metabolic processGCLCIDAHumanPMID:9841880
Biological ProcessGO:0006750glutathione biosynthetic processGCLCIDAHumanPMID:10395918
Biological ProcessGO:0006750glutathione biosynthetic processGCLCIMPHumanPMID:12663448
Biological ProcessGO:0006750glutathione biosynthetic processGCLCIDAHumanPMID:8104187
Biological ProcessGO:0006750glutathione biosynthetic processGCLCIDAHumanPMID:9675072
Biological ProcessGO:0006750glutathione biosynthetic processGclcIMPMGI:MGI:2387010MousePMID:10805773
Biological ProcessGO:0006750glutathione biosynthetic processGclcIDAMousePMID:16081425
Biological ProcessGO:0006750glutathione biosynthetic processGclcIMPRatPMID:16183645|RGD:1582661
Biological ProcessGO:0006749glutathione metabolic processGclcIMPMGI:MGI:2429419MousePMID:11118286
Biological ProcessGO:0019852L-ascorbic acid metabolic processGclcIMPMGI:MGI:2429419MousePMID:11118286
Biological ProcessGO:0043066negative regulation of apoptotic processGCLCIDAHumanPMID:10439045
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionGCLCIDAHumanPMID:10439045
Biological ProcessGO:2001237negative regulation of extrinsic apoptotic signaling pathwayGclcIGIMGI:MGI:104995MousePMID:15288121
Biological ProcessGO:2000490negative regulation of hepatic stellate cell activationGclcIMPRatPMID:22942279|RGD:11049542
Biological ProcessGO:1901029negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayGclcIGIMGI:MGI:104995MousePMID:15288121
Biological ProcessGO:0043524negative regulation of neuron apoptotic processGclcIMPRatPMID:16183645|RGD:1582661
Biological ProcessGO:0031397negative regulation of protein ubiquitinationGclcIMPMGI:MGI:2387010MousePMID:17189825
Biological ProcessGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processGclcIMPMGI:MGI:2387010MousePMID:17189825
Biological ProcessGO:0051900regulation of mitochondrial depolarizationGclcIGIMGI:MGI:104995MousePMID:15288121
Biological ProcessGO:0014823response to activityGclcIEPRatPMID:20018823|RGD:10402378
Biological ProcessGO:0046685response to arsenic-containing substanceGclcIMPMGI:MGI:2387010MousePMID:17189825
Biological ProcessGO:0046686response to cadmium ionGclcIEPRatPMID:10702364|RGD:10402382
Biological ProcessGO:0009408response to heatGCLCIDAHumanPMID:8104187
Biological ProcessGO:0009725response to hormoneGCLCIDAHumanPMID:8104187
Biological ProcessGO:0044752response to human chorionic gonadotropinGclcIEPRatPMID:15811874|RGD:10402375
Biological ProcessGO:0070555response to interleukin-1GclcIEPRatPMID:15485876|RGD:10402384
Biological ProcessGO:0051409response to nitrosative stressGclcIMPRatPMID:16183645|RGD:1582661
Biological ProcessGO:0007584response to nutrientGclcIEPRatPMID:22906634|RGD:11049541
Biological ProcessGO:0006979response to oxidative stressGCLCIDAHumanPMID:10395918
Biological ProcessGO:0006979response to oxidative stressGCLCIDAHumanPMID:11972604
Biological ProcessGO:0006979response to oxidative stressGclcIMPRatPMID:16183645|RGD:1582661
Biological ProcessGO:0009410response to xenobiotic stimulusGclcIMPMGI:MGI:2387010MousePMID:17189825

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory