Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GCLM
  • Mouse genes Gclm
  • Rat genes Gclm
  • Zfish genes gclm
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gclm

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	GCLM	IMP		Human	PMID:16183645
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	Gclm	IMP		Rat	PMID:16183645|RGD:1582661
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	Gclm	IDA		Rat	PMID:8104188|RGD:632762
Molecular Function	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	GCLM	IPI	UniProtKB:P48506	Human	PMID:9675072
Molecular Function	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	GCLM	IPI	UniProtKB:P48506	Human	PMID:9841880
Molecular Function	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Gclm	IDA		Mouse	PMID:12384496
Molecular Function	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Gclm	IDA		Rat	PMID:16137247|RGD:1582663
Molecular Function	GO:0005515	protein binding	GCLM	IPI	UniProtKB:P48506	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	GCLM	IPI	UniProtKB:Q9UJX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GCLM	IPI	UniProtKB:P48506	Human	PMID:9675072
Molecular Function	GO:0005515	protein binding	Gclm	IPI	PR:P97494	Mouse	PMID:12384496
Molecular Function	GO:0005515	protein binding	Gclm	IPI	PR:P97494	Mouse	PMID:16081425
Molecular Function	GO:0044877	protein-containing complex binding	Gclm	IDA		Rat	PMID:16137247|RGD:1582663
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	GCLM	IDA		Human	PMID:9675072
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	GCLM	IDA		Human	PMID:9841880
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	Gclm	IDA		Mouse	PMID:16081425
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	Gclm	IDA		Mouse	PMID:12384496
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	Gclm	IDA		Rat	PMID:16137247|RGD:1582663
Biological Process	GO:0007568	aging	Gclm	IEP		Rat	PMID:16647047|RGD:10402373
Biological Process	GO:0008637	apoptotic mitochondrial changes	Gclm	IGI	MGI:MGI:104990	Mouse	PMID:15288121
Biological Process	GO:0097746	blood vessel diameter maintenance	GCLM	IMP		Human	PMID:12975258
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Gclm	IEP		Rat	PMID:18042181|RGD:10402377
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Gclm	IEP		Rat	PMID:18042181|RGD:10402377
Biological Process	GO:0071333	cellular response to glucose stimulus	Gclm	IEP		Rat	PMID:20466058|RGD:10402379
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	Gclm	IEP		Rat	PMID:20466058|RGD:10402379
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Gclm	IEP		Mouse	PMID:20439489
Biological Process	GO:0097069	cellular response to thyroxine stimulus	Gclm	IEP		Rat	PMID:17291985|RGD:10402376
Biological Process	GO:0006534	cysteine metabolic process	Gclm	IMP	MGI:MGI:2447852	Mouse	PMID:12384496
Biological Process	GO:0006536	glutamate metabolic process	GCLM	IDA		Human	PMID:9841880
Biological Process	GO:0006536	glutamate metabolic process	GCLM	IDA		Human	PMID:9895302
Biological Process	GO:0006750	glutathione biosynthetic process	GCLM	IDA		Human	PMID:10395918
Biological Process	GO:0006750	glutathione biosynthetic process	GCLM	IMP		Human	PMID:12081989
Biological Process	GO:0006750	glutathione biosynthetic process	GCLM	IDA		Human	PMID:9675072
Biological Process	GO:0006750	glutathione biosynthetic process	Gclm	IDA		Mouse	PMID:16081425
Biological Process	GO:0006750	glutathione biosynthetic process	Gclm	IMP		Rat	PMID:16183645|RGD:1582661
Biological Process	GO:0006749	glutathione metabolic process	Gclm	IMP	MGI:MGI:2447852	Mouse	PMID:12384496
Biological Process	GO:0035733	hepatic stellate cell activation	Gclm	IEP		Rat	PMID:22942279|RGD:11049542
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Gclm	IGI	MGI:MGI:104990	Mouse	PMID:15288121
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Gclm	IMP		Rat	PMID:16183645|RGD:1582661
Biological Process	GO:0035229	positive regulation of glutamate-cysteine ligase activity	Gclm	IDA		Mouse	PMID:16081425
Biological Process	GO:0035229	positive regulation of glutamate-cysteine ligase activity	Gclm	IDA		Mouse	PMID:15288121
Biological Process	GO:0035229	positive regulation of glutamate-cysteine ligase activity	Gclm	IDA		Mouse	PMID:12384496
Biological Process	GO:0035229	positive regulation of glutamate-cysteine ligase activity	Gclm	IDA		Rat	PMID:16137247|RGD:1582663
Biological Process	GO:0051900	regulation of mitochondrial depolarization	Gclm	IGI	MGI:MGI:104990	Mouse	PMID:15288121
Biological Process	GO:0014823	response to activity	Gclm	IEP		Rat	PMID:20018823|RGD:10402378
Biological Process	GO:0044752	response to human chorionic gonadotropin	Gclm	IEP		Rat	PMID:15811874|RGD:10402375
Biological Process	GO:0051409	response to nitrosative stress	Gclm	IMP		Rat	PMID:16183645|RGD:1582661
Biological Process	GO:0007584	response to nutrient	Gclm	IEP		Rat	PMID:22906634|RGD:11049541
Biological Process	GO:0006979	response to oxidative stress	GCLM	IDA		Human	PMID:10395918
Biological Process	GO:0006979	response to oxidative stress	Gclm	IMP	MGI:MGI:2447852	Mouse	PMID:12384496
Biological Process	GO:0006979	response to oxidative stress	Gclm	IMP		Rat	PMID:16183645|RGD:1582661
Biological Process	GO:0009410	response to xenobiotic stimulus	GCLM	IDA		Human	PMID:9895302

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern