Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GDF11
  • Mouse genes Gdf11
  • Rat genes Gdf11
  • Zfish genes gdf11
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gdf11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	GDF11	IPI	UniProtKB:Q8TEU8	Human	PMID:18596030
Molecular Function	GO:0005515	protein binding	GDF11	IPI	UniProtKB:Q96NZ8	Human	PMID:18596030
Molecular Function	GO:0005515	protein binding	GDF11	IPI	UniProtKB:P19883-2	Human	PMID:28257634
Molecular Function	GO:0005515	protein binding	Gdf11	IPI	PR:P27040	Mouse	PMID:16845371
Cellular Component	GO:0005615	extracellular space	Gdf11	IDA		Mouse	PMID:12729564
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	GDF11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	GDF11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	GDF11	IDA		Human	PMID:24019467
Biological Process	GO:0035881	amacrine cell differentiation	Gdf11	IDA		Mouse	PMID:15976303
Biological Process	GO:0009887	animal organ morphogenesis	Gdf11	IMP	MGI:MGI:2449672	Mouse	PMID:15548585
Biological Process	GO:0009952	anterior/posterior pattern specification	Gdf11	IMP	MGI:MGI:2449672	Mouse	PMID:10391213
Biological Process	GO:0009952	anterior/posterior pattern specification	Gdf11	IMP	MGI:MGI:5544775	Mouse	PMID:23918385
Biological Process	GO:0009952	anterior/posterior pattern specification	gdf11	IMP	ZFIN:ZDB-MRPHLNO-101117-5	Zfish	PMID:20692249
Biological Process	GO:0048593	camera-type eye morphogenesis	Gdf11	IMP	MGI:MGI:2449673	Mouse	PMID:15976303
Biological Process	GO:0008283	cell population proliferation	Gdf11	IMP	MGI:MGI:2449672	Mouse	PMID:15548585
Biological Process	GO:0001656	metanephros development	Gdf11	IDA		Mouse	PMID:12729564
Biological Process	GO:1902870	negative regulation of amacrine cell differentiation	Gdf11	IDA		Mouse	PMID:15976303
Biological Process	GO:0008285	negative regulation of cell population proliferation	Gdf11	IMP	MGI:MGI:2449672	Mouse	PMID:15548585
Biological Process	GO:0045665	negative regulation of neuron differentiation	Gdf11	IDA		Mouse	PMID:15976303
Biological Process	GO:0045665	negative regulation of neuron differentiation	Gdf11	IMP		Rat	PMID:15988002|RGD:2316479
Biological Process	GO:0030182	neuron differentiation	Gdf11	IDA		Mouse	PMID:15976303
Biological Process	GO:0031016	pancreas development	Gdf11	IMP	MGI:MGI:2449672	Mouse	PMID:15548585
Biological Process	GO:0060021	roof of mouth development	Gdf11	IGI	MGI:MGI:2669209	Mouse	PMID:24019467
Biological Process	GO:0001501	skeletal system development	Gdf11	IGI	MGI:MGI:2669209	Mouse	PMID:24019467
Biological Process	GO:0001501	skeletal system development	Gdf11	IGI	MGI:MGI:2670967	Mouse	PMID:24019467
Biological Process	GO:0060395	SMAD protein signal transduction	GDF11	IMP		Human	PMID:28257634
Biological Process	GO:0060395	SMAD protein signal transduction	Gdf11	IDA		Mouse	MGI:MGI:3695190|PMID:16845371
Biological Process	GO:0021512	spinal cord anterior/posterior patterning	Gdf11	IMP	MGI:MGI:2449672	Mouse	PMID:16790475
Biological Process	GO:0072560	type B pancreatic cell maturation	Gdf11	IMP	MGI:MGI:2449672	Mouse	PMID:15548585
Biological Process	GO:0001657	ureteric bud development	Gdf11	IMP	MGI:MGI:2449672	Mouse	PMID:12729564

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern