Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GDF15
  • Mouse genes Gdf15
  • Rat genes Gdf15
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gdf15

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:Q99750	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:O14980	Human	PMID:25893289
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:Q6SJE0	Human	PMID:28846098
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:Q6UXV0	Human	PMID:28846098
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:Q6SJE0|UniProtKB:Q6UXV0	Human	PMID:28846099
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:Q6UXV0	Human	PMID:28953886
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:P59991	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:Q13185	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GDF15	IPI	UniProtKB:Q9Y6A5	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	GDF15	IDA		Human	PMID:29046435
Molecular Function	GO:0042803	protein homodimerization activity	Gdf15	IDA		Mouse	MGI:MGI:5916661|PMID:29046435
Molecular Function	GO:0042803	protein homodimerization activity	Gdf15	IDA		Rat	PMID:29046435|RGD:13524619
Cellular Component	GO:0062023	collagen-containing extracellular matrix	GDF15	HDA		Human	PMID:28327460
Cellular Component	GO:0005737	cytoplasm	GDF15	IDA		Human	PMID:25893289
Cellular Component	GO:0070062	extracellular exosome	GDF15	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	GDF15	IDA		Human	PMID:28572090
Cellular Component	GO:0005576	extracellular region	GDF15	IDA		Human	PMID:29046435
Cellular Component	GO:0005576	extracellular region	Gdf15	IDA		Mouse	MGI:MGI:6154425|PMID:28572090
Cellular Component	GO:0005576	extracellular region	Gdf15	IDA		Mouse	MGI:MGI:5916661|PMID:29046435
Cellular Component	GO:0005576	extracellular region	Gdf15	IDA		Rat	PMID:29046435|RGD:13524619
Cellular Component	GO:0005615	extracellular space	GDF15	IDA		Human	PMID:25893289
Cellular Component	GO:0005794	Golgi apparatus	GDF15	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GDF15	IDA		Human	PMID:25893289
Biological Process	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	GDF15	IDA		Human	PMID:28953886
Biological Process	GO:0060400	negative regulation of growth hormone receptor signaling pathway	Gdf15	IDA		Mouse	MGI:MGI:6154425|PMID:28572090
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Gdf15	IDA		Mouse	MGI:MGI:6154425|PMID:28572090
Biological Process	GO:0043410	positive regulation of MAPK cascade	GDF15	IMP		Human	PMID:28846099
Biological Process	GO:0043410	positive regulation of MAPK cascade	GDF15	IDA		Human	PMID:28953886
Biological Process	GO:0043410	positive regulation of MAPK cascade	Gdf15	IMP		Mouse	MGI:MGI:6101250|PMID:28953886
Biological Process	GO:1901741	positive regulation of myoblast fusion	Gdf15	IMP		Mouse	PMID:23844157
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	GDF15	IDA		Human	PMID:28846097
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	GDF15	IMP		Human	PMID:28846099
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	GDF15	IDA		Human	PMID:28846097
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	GDF15	IDA		Human	PMID:28846098
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	GDF15	IDA		Human	PMID:28846099
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	GDF15	IDA		Human	PMID:28953886
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	GDF15	IDA		Human	PMID:29046435
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	Gdf15	IDA		Mouse	MGI:MGI:5916661|PMID:29046435
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	Gdf15	IMP		Mouse	MGI:MGI:5491083|PMID:23468844
Biological Process	GO:0002023	reduction of food intake in response to dietary excess	Gdf15	IDA		Mouse	MGI:MGI:6103404|PMID:28846097
Biological Process	GO:0060395	SMAD protein signal transduction	GDF15	IDA		Human	PMID:25893289

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern