Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GDF5
  • Mouse genes Gdf5
  • Rat genes Gdf5
  • Zfish genes gdf5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gdf5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036122	BMP binding	GDF5	IPI	UniProtKB:O00238	Human	PMID:21976273
Molecular Function	GO:0036122	BMP binding	GDF5	IPI	UniProtKB:P36894	Human	PMID:21976273
Molecular Function	GO:0036122	BMP binding	GDF5	IPI	UniProtKB:Q13873	Human	PMID:21976273
Molecular Function	GO:0042802	identical protein binding	GDF5	IPI	UniProtKB:P43026	Human	PMID:25174448
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:O00238	Human	PMID:16127465
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:P36894	Human	PMID:16127465
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:P35555	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:P35556	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:O00238	Human	PMID:19229295
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:P36894	Human	PMID:19229295
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:Q13873	Human	PMID:19229295
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:P36894	Human	PMID:21543859
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:Q13253	Human	PMID:21976273
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:O00238	Human	PMID:24098149
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:P36894	Human	PMID:24098149
Molecular Function	GO:0005515	protein binding	GDF5	IPI	UniProtKB:Q13253	Human	PMID:24098149
Molecular Function	GO:0005515	protein binding	Gdf5	IPI	UniProtKB:Q9D236	Mouse	MGI:MGI:3046453|PMID:15206957
Molecular Function	GO:0005515	protein binding	Gdf5	IPI	PR:Q8VEA6	Mouse	PMID:14660436
Molecular Function	GO:0005515	protein binding	Gdf5	IPI	PR:Q9R118	Mouse	PMID:14973287
Molecular Function	GO:0005102	signaling receptor binding	Gdf5	IMP		Rat	PMID:15906156|RGD:1598708
Biological Process	GO:0060591	chondroblast differentiation	GDF5	IDA		Human	PMID:25092592
Biological Process	GO:0002062	chondrocyte differentiation	Gdf5	IDA		Mouse	PMID:9885252
Biological Process	GO:0030326	embryonic limb morphogenesis	Gdf5	IMP	MGI:MGI:1855974	Mouse	PMID:15542031
Biological Process	GO:0035136	forelimb morphogenesis	Gdf5	IMP	MGI:MGI:1855974	Mouse	PMID:8145850
Biological Process	GO:0035137	hindlimb morphogenesis	Gdf5	IMP	MGI:MGI:1855974	Mouse	PMID:8145850
Biological Process	GO:0035137	hindlimb morphogenesis	Gdf5	IMP	MGI:MGI:1856810	Mouse	PMID:17085896
Biological Process	GO:0035141	medial fin morphogenesis	gdf5	IMP	ZFIN:ZDB-GENO-221024-1	Zfish	PMID:34242444
Biological Process	GO:0097152	mesenchymal cell apoptotic process	Gdf5	IMP	MGI:MGI:1855974	Mouse	PMID:15542031
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	GDF5	IDA		Human	PMID:21976273
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	GDF5	IDA		Human	PMID:9950587
Biological Process	GO:2001054	negative regulation of mesenchymal cell apoptotic process	Gdf5	IMP	MGI:MGI:1855974	Mouse	PMID:15542031
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Gdf5	IDA		Rat	PMID:15906156|RGD:1598708
Biological Process	GO:0043932	ossification involved in bone remodeling	Gdf5	IEP		Rat	PMID:10404008|RGD:2289026
Biological Process	GO:0035138	pectoral fin morphogenesis	gdf5	IMP	ZFIN:ZDB-GENO-221024-1	Zfish	PMID:34242444
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	GDF5	IDA		Human	PMID:21976273
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	GDF5	IDA		Human	PMID:24098149
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	GDF5	IDA		Human	PMID:21976273
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	GDF5	IDA		Human	PMID:24098149
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	Gdf5	IGI	MGI:MGI:1927616	Mouse	PMID:18363966
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	Gdf5	IDA		Mouse	PMID:9885252
Biological Process	GO:0045666	positive regulation of neuron differentiation	Gdf5	IDA		Rat	PMID:15906156|RGD:1598708
Biological Process	GO:0040014	regulation of multicellular organism growth	Gdf5	IMP	MGI:MGI:1856810	Mouse	PMID:17085896
Biological Process	GO:0060390	regulation of SMAD protein signal transduction	GDF5	IDA		Human	PMID:21976273
Biological Process	GO:0009612	response to mechanical stimulus	Gdf5	IEP		Rat	PMID:10404008|RGD:2289026
Biological Process	GO:0048705	skeletal system morphogenesis	gdf5	IMP	ZFIN:ZDB-GENO-221024-1	Zfish	PMID:34242444
Biological Process	GO:0060395	SMAD protein signal transduction	GDF5	IDA		Human	PMID:21976273
Biological Process	GO:0060395	SMAD protein signal transduction	GDF5	IDA		Human	PMID:25092592
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	Gdf5	IGI	MGI:MGI:1346865	Mouse	PMID:18363966
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	Gdf5	IGI	MGI:MGI:107191	Mouse	PMID:18363966
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	Gdf5	IGI	MGI:MGI:1927616	Mouse	PMID:18363966

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern