Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GDF6
  • Mouse genes Gdf6
  • Rat genes Gdf6
  • Zfish genes gdf6a,gdf6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gdf6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Gdf6	IPI	PR:P43028	Mouse	PMID:16049014
Cellular Component	GO:0005615	extracellular space	Gdf6	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Biological Process	GO:0032924	activin receptor signaling pathway	GDF6	IDA		Human	PMID:16049014
Biological Process	GO:0006915	apoptotic process	gdf6a	IDA		Zfish	PMID:23847306|ZFIN:ZDB-PUB-130722-5
Biological Process	GO:0001955	blood vessel maturation	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:29284606
Biological Process	GO:0048514	blood vessel morphogenesis	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-070904-4	Zfish	PMID:12413901
Biological Process	GO:0030509	BMP signaling pathway	GDF6	IDA		Human	PMID:16049014
Biological Process	GO:0030509	BMP signaling pathway	Gdf6	IMP		Mouse	MGI:MGI:5751611|PMID:26774823
Biological Process	GO:0030509	BMP signaling pathway	Gdf6	IDA		Mouse	PMID:16049014
Biological Process	GO:0030509	BMP signaling pathway	Gdf6	IGI	MGI:MGI:107191	Mouse	PMID:16049014
Biological Process	GO:0030509	BMP signaling pathway	Gdf6	IGI	MGI:MGI:1338938	Mouse	PMID:16049014
Biological Process	GO:0043010	camera-type eye development	gdf6a	IGI	ZFIN:ZDB-GENO-140623-8,ZFIN:ZDB-MRPHLNO-140618-4	Zfish	PMID:23737474
Biological Process	GO:0043010	camera-type eye development	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:23737474
Biological Process	GO:0043010	camera-type eye development	gdf6a	IGI	ZFIN:ZDB-GENO-091208-7,ZFIN:ZDB-MRPHLNO-140618-4	Zfish	PMID:23737474
Biological Process	GO:0043010	camera-type eye development	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-091116-1	Zfish	PMID:19129173
Biological Process	GO:0043010	camera-type eye development	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-050708-1	Zfish	PMID:19129173
Biological Process	GO:0060219	camera-type eye photoreceptor cell differentiation	gdf6a	IGI	ZFIN:ZDB-GENE-990726-27	Zfish	PMID:24681822
Biological Process	GO:0035788	cell migration involved in metanephros development	Gdf6	IMP		Mouse	PMID:32737436
Biological Process	GO:0048264	determination of ventral identity	gdf6a	IMP		Zfish	PMID:12601179
Biological Process	GO:0048264	determination of ventral identity	gdf6a	IDA		Zfish	PMID:11091070
Biological Process	GO:0048264	determination of ventral identity	gdf6a	IDA		Zfish	PMID:12601179
Biological Process	GO:0009953	dorsal/ventral pattern formation	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:19164594
Biological Process	GO:0009953	dorsal/ventral pattern formation	gdf6a	IMP		Zfish	PMID:12601179
Biological Process	GO:0031076	embryonic camera-type eye development	gdf6a	IMP	ZFIN:ZDB-GENO-110203-12	Zfish	PMID:21070663
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-050708-1	Zfish	PMID:17634100
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:19164594
Biological Process	GO:0048706	embryonic skeletal system development	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-091116-1	Zfish	PMID:19129173
Biological Process	GO:0048706	embryonic skeletal system development	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-050708-1	Zfish	PMID:19129173
Biological Process	GO:0042462	eye photoreceptor cell development	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:32293666
Biological Process	GO:0042462	eye photoreceptor cell development	gdf6a	IMP	ZFIN:ZDB-GENO-210610-2	Zfish	PMID:32293666
Biological Process	GO:0042462	eye photoreceptor cell development	gdf6a	IMP	ZFIN:ZDB-GENO-140729-2	Zfish	PMID:32293666
Biological Process	GO:0042462	eye photoreceptor cell development	gdf6a	IMP	ZFIN:ZDB-GENO-210611-1	Zfish	PMID:32293666
Biological Process	GO:0042462	eye photoreceptor cell development	gdf6a	IMP	ZFIN:ZDB-GENO-210609-9	Zfish	PMID:32293666
Biological Process	GO:0045444	fat cell differentiation	Gdf6	IMP		Mouse	MGI:MGI:5751611|PMID:26774823
Biological Process	GO:0001656	metanephros development	GDF6	IDA		Human	PMID:32737436
Biological Process	GO:0001656	metanephros development	Gdf6	IMP		Mouse	PMID:32737436
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:29284606
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	GDF6	IDA		Human	PMID:16049014
Biological Process	GO:0046552	photoreceptor cell fate commitment	gdf6a	IMP	ZFIN:ZDB-GENO-160613-2	Zfish	PMID:26893342
Biological Process	GO:0046552	photoreceptor cell fate commitment	gdf6a	IMP	ZFIN:ZDB-GENO-160613-3	Zfish	PMID:26893342
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-050708-1	Zfish	PMID:23133395
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	GDF6	IMP		Human	PMID:26643732
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	GDF6	IDA		Human	PMID:16049014
Biological Process	GO:0045666	positive regulation of neuron differentiation	Gdf6	IDA		Mouse	PMID:9786991
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	Gdf6	IMP		Mouse	MGI:MGI:5751611|PMID:26774823
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GDF6	IDA		Human	PMID:16049014
Biological Process	GO:0030510	regulation of BMP signaling pathway	gdf6a	IMP		Zfish	PMID:12601179
Biological Process	GO:0042127	regulation of cell population proliferation	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:23737474
Biological Process	GO:0060041	retina development in camera-type eye	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-091116-1	Zfish	PMID:17236135
Biological Process	GO:0060041	retina development in camera-type eye	gdf6a	IMP	ZFIN:ZDB-GENO-110203-12	Zfish	PMID:21070663
Biological Process	GO:0060041	retina development in camera-type eye	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-050708-1	Zfish	PMID:17236135
Biological Process	GO:0060041	retina development in camera-type eye	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:23307924
Biological Process	GO:0001895	retina homeostasis	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:23307924
Biological Process	GO:0061298	retina vasculature development in camera-type eye	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:29522511
Biological Process	GO:0061298	retina vasculature development in camera-type eye	gdf6a	IMP	ZFIN:ZDB-GENO-181205-4	Zfish	PMID:29522511
Biological Process	GO:1990009	retinal cell apoptotic process	gdf6a	IDA		Zfish	PMID:23307924|ZFIN:ZDB-PUB-130124-9
Biological Process	GO:0042670	retinal cone cell differentiation	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:24681822
Biological Process	GO:0042671	retinal cone cell fate determination	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:30592497
Biological Process	GO:0031290	retinal ganglion cell axon guidance	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:19164594
Biological Process	GO:0048741	skeletal muscle fiber development	gdf6a	IMP	ZFIN:ZDB-GENO-091208-7	Zfish	PMID:23133395
Biological Process	GO:0048741	skeletal muscle fiber development	gdf6a	IMP	ZFIN:ZDB-MRPHLNO-050708-1	Zfish	PMID:23133395
Biological Process	GO:0060395	SMAD protein signal transduction	GDF6	IMP		Human	PMID:26643732
Biological Process	GO:0060395	SMAD protein signal transduction	Gdf6	IMP		Mouse	MGI:MGI:5751611|PMID:26774823

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern