Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gdnf

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GDNF
- Mouse genes Gdnf
- Rat genes Gdnf
- Zfish genes gdnfa,gdnfb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gdnf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030116	glial cell-derived neurotrophic factor receptor binding	Gdnf	IPI	UniProtKB:Q62997	Rat	PMID:10545102\|RGD:12793041
Molecular Function	GO:0030116	glial cell-derived neurotrophic factor receptor binding	Gdnf	IPI	RGD:2681	Rat	PMID:15709767\|RGD:6480096
Molecular Function	GO:0008083	growth factor activity	Gdnf	IDA		Rat	PMID:12595497\|RGD:1358712
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	gdnfa	IDA		Zfish	PMID:28467503
Molecular Function	GO:0005515	protein binding	GDNF	IPI	UniProtKB:P07949	Human	PMID:21994944
Molecular Function	GO:0005515	protein binding	GDNF	IPI	UniProtKB:Q92673	Human	PMID:21994944
Molecular Function	GO:0005515	protein binding	GDNF	IPI	UniProtKB:Q6RW13	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	gdnfa	IPI	ZFIN:ZDB-GENE-010226-2	Zfish	PMID:28467503
Molecular Function	GO:0042803	protein homodimerization activity	GDNF	IDA		Human	PMID:8493557
Molecular Function	GO:0042803	protein homodimerization activity	GDNF	IDA		Human	PMID:8988018
Molecular Function	GO:0042803	protein homodimerization activity	Gdnf	IDA		Rat	PMID:9187648\|RGD:12793052
Molecular Function	GO:0048018	receptor ligand activity	Gdnf	IMP		Rat	PMID:10545102\|RGD:12793041
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Gdnf	IPI	UniProtKB:P07949	Rat	PMID:10545102\|RGD:12793041
Cellular Component	GO:0005576	extracellular region	GDNF	IDA		Human	PMID:9811930
Cellular Component	GO:0005615	extracellular space	Gdnf	IMP		Rat	PMID:10545102\|RGD:12793041
Cellular Component	GO:0005615	extracellular space	Gdnf	IDA		Rat	PMID:12595497\|RGD:1358712
Cellular Component	GO:0005794	Golgi apparatus	GDNF	IDA		Human	PMID:21994944
Cellular Component	GO:0043235	receptor complex	Gdnf	IDA		Rat	PMID:15709767\|RGD:6480096
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Gdnf	IMP		Mouse	MGI:MGI:81287\|PMID:8657307
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Gdnf	IDA		Mouse	PMID:13678594
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Gdnf	IDA		Mouse	PMID:21281623
Biological Process	GO:0008283	cell population proliferation	Gdnf	IDA		Rat	PMID:12595497\|RGD:1358712
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Gdnf	IDA		Rat	PMID:17537984\|RGD:1643596
Biological Process	GO:0071679	commissural neuron axon guidance	Gdnf	IGI	UniProtKB:P13595	Mouse	MGI:MGI:5440338\|PMID:22998873
Biological Process	GO:0021536	diencephalon development	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-5	Zfish	PMID:32583440
Biological Process	GO:0021536	diencephalon development	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-6	Zfish	PMID:32583440
Biological Process	GO:0021536	diencephalon development	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-7	Zfish	PMID:32583440
Biological Process	GO:0021536	diencephalon development	gdnfa	IMP	ZFIN:ZDB-GENO-220815-2	Zfish	PMID:32583440
Biological Process	GO:0021536	diencephalon development	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-3	Zfish	PMID:32583440
Biological Process	GO:0021536	diencephalon development	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-4	Zfish	PMID:32583440
Biological Process	GO:0021516	dorsal spinal cord development	Gdnf	IMP		Mouse	MGI:MGI:5440338\|PMID:22998873
Biological Process	GO:0048568	embryonic organ development	Gdnf	IMP		Mouse	MGI:MGI:5440338\|PMID:22998873
Biological Process	GO:0048484	enteric nervous system development	Gdnf	IMP		Mouse	MGI:MGI:81286\|PMID:8657306
Biological Process	GO:0048484	enteric nervous system development	Gdnf	IDA		Mouse	MGI:MGI:81285\|PMID:8657308
Biological Process	GO:0048484	enteric nervous system development	gdnfa	IMP	ZFIN:ZDB-MRPHLNO-061204-1	Zfish	PMID:11237470
Biological Process	GO:0008584	male gonad development	Gdnf	IEP		Rat	PMID:22111653\|RGD:6478715
Biological Process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	Gdnf	IEP		Mouse	MGI:MGI:1335967\|PMID:10322633
Biological Process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	Gdnf	IDA		Rat	PMID:17522159\|RGD:8656002
Biological Process	GO:0001656	metanephros development	Gdnf	IMP		Mouse	MGI:MGI:81285\|PMID:8657308
Biological Process	GO:0001656	metanephros development	Gdnf	IGI	MGI:MGI:109442	Mouse	PMID:17537792
Biological Process	GO:0001656	metanephros development	Gdnf	IGI	MGI:MGI:1315205	Mouse	PMID:15130495
Biological Process	GO:0001656	metanephros development	Gdnf	IMP	MGI:MGI:2136843	Mouse	PMID:17537792
Biological Process	GO:0030901	midbrain development	Gdnf	IEP		Rat	PMID:16650834\|RGD:2324945
Biological Process	GO:0048255	mRNA stabilization	GDNF	IDA		Human	PMID:12358785
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GDNF	IDA		Human	PMID:10921886
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	GDNF	IDA		Human	PMID:8493557
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Gdnf	IMP	MGI:MGI:3528739	Mouse	PMID:15582775
Biological Process	GO:0007399	nervous system development	Gdnf	IMP	MGI:MGI:2136843	Mouse	PMID:8657308
Biological Process	GO:0001755	neural crest cell migration	GDNF	IDA		Human	PMID:15242795
Biological Process	GO:0030182	neuron differentiation	Gdnf	IDA		Rat	PMID:15109990\|RGD:1358711
Biological Process	GO:0031175	neuron projection development	GDNF	IDA		Human	PMID:15242795
Biological Process	GO:0001759	organ induction	Gdnf	IGI	MGI:MGI:1345139	Mouse	PMID:15691764
Biological Process	GO:0007422	peripheral nervous system development	Gdnf	IMP	MGI:MGI:3528739	Mouse	PMID:15582775
Biological Process	GO:0007422	peripheral nervous system development	Gdnf	IMP	MGI:MGI:2136846	Mouse	PMID:11774071
Biological Process	GO:0030432	peristalsis	Gdnf	IMP		Mouse	MGI:MGI:81287\|PMID:8657307
Biological Process	GO:0030432	peristalsis	Gdnf	IMP	MGI:MGI:2136846	Mouse	PMID:11774071
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GDNF	IDA		Human	PMID:17229286
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GDNF	IDA		Human	PMID:8657307
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Gdnf	IMP		Mouse	MGI:MGI:5284782\|PMID:17229286
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Gdnf	IDA		Rat	PMID:17522159\|RGD:8656002
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Gdnf	IMP		Rat	PMID:17537984\|RGD:1643596
Biological Process	GO:0045597	positive regulation of cell differentiation	GDNF	IGI	UniProtKB:P14138	Human	PMID:22897442
Biological Process	GO:0008284	positive regulation of cell population proliferation	GDNF	IDA		Human	PMID:22897442
Biological Process	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	Gdnf	IMP		Mouse	MGI:MGI:81286\|PMID:8657306
Biological Process	GO:0032770	positive regulation of monooxygenase activity	GDNF	IDA		Human	PMID:12358785
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Gdnf	IMP		Rat	PMID:10545102\|RGD:12793041
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GDNF	IDA		Human	PMID:12358785
Biological Process	GO:0072107	positive regulation of ureteric bud formation	GDNF	IDA		Human	PMID:8657307
Biological Process	GO:0021784	postganglionic parasympathetic fiber development	Gdnf	IMP		Mouse	MGI:MGI:81287\|PMID:8657307
Biological Process	GO:0001941	postsynaptic membrane organization	Gdnf	IDA		Mouse	PMID:15381279
Biological Process	GO:0065003	protein-containing complex assembly	gdnfa	IPI	ZFIN:ZDB-GENE-010226-1,ZFIN:ZDB-GENE-010226-2	Zfish	PMID:29889908
Biological Process	GO:0065003	protein-containing complex assembly	gdnfa	IPI	ZFIN:ZDB-GENE-010226-1,ZFIN:ZDB-GENE-010226-2,ZFIN:ZDB-GENE-980526-307	Zfish	PMID:29889908
Biological Process	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	GDNF	IDA		Human	PMID:8493557
Biological Process	GO:1904338	regulation of dopaminergic neuron differentiation	gdnfa	IMP	ZFIN:ZDB-GENO-220815-2	Zfish	PMID:32583440
Biological Process	GO:1904338	regulation of dopaminergic neuron differentiation	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-4	Zfish	PMID:32583440
Biological Process	GO:1904338	regulation of dopaminergic neuron differentiation	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-5	Zfish	PMID:32583440
Biological Process	GO:1904338	regulation of dopaminergic neuron differentiation	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-3	Zfish	PMID:32583440
Biological Process	GO:1904338	regulation of dopaminergic neuron differentiation	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-6	Zfish	PMID:32583440
Biological Process	GO:1904338	regulation of dopaminergic neuron differentiation	gdnfa	IMP	ZFIN:ZDB-CRISPR-211025-7	Zfish	PMID:32583440
Biological Process	GO:0010468	regulation of gene expression	GDNF	IGI	UniProtKB:P14138	Human	PMID:22897442
Biological Process	GO:0060688	regulation of morphogenesis of a branching structure	Gdnf	IDA		Mouse	PMID:13678594
Biological Process	GO:2001260	regulation of semaphorin-plexin signaling pathway	Gdnf	IGI	UniProtKB:P13595	Mouse	MGI:MGI:5440338\|PMID:22998873
Biological Process	GO:0072106	regulation of ureteric bud formation	Gdnf	IDA		Rat	PMID:19112489\|RGD:8656008
Biological Process	GO:0009611	response to wounding	Gdnf	IDA		Rat	PMID:15671854\|RGD:1358710
Biological Process	GO:0060041	retina development in camera-type eye	Gdnf	IEP		Rat	PMID:16650834\|RGD:2324945
Biological Process	GO:0048485	sympathetic nervous system development	Gdnf	IMP		Mouse	MGI:MGI:81285\|PMID:8657308
Biological Process	GO:0001657	ureteric bud development	Gdnf	IDA		Mouse	PMID:15905075
Biological Process	GO:0001657	ureteric bud development	Gdnf	IGI	MGI:MGI:1345139	Mouse	PMID:15691764
Biological Process	GO:0060676	ureteric bud formation	Gdnf	IMP		Mouse	MGI:MGI:81287\|PMID:8657307

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.