Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GFI1
  • Mouse genes Gfi1
  • Rat genes Gfi1
  • Zfish genes gfi1aa,gfi1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gfi1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	Gfi1	IDA		Mouse	MGI:MGI:5284774|PMID:17707228
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GFI1	IDA		Human	PMID:19506020
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:O54714	Human	PMID:11060035
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q9Y6X2	Human	PMID:11060035
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q06455	Human	PMID:12874834
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q13547	Human	PMID:16287849
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q96KQ7	Human	PMID:16287849
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:P17433	Human	PMID:17197705
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q9NQX1	Human	PMID:17636019
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q91XC0	Human	PMID:17909014
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q96IF1	Human	PMID:18805794
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:P08246	Human	PMID:19506020
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q92802	Human	PMID:19506020
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q60821	Human	PMID:20190815
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q04206	Human	PMID:20547752
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q04207	Human	PMID:20547752
Molecular Function	GO:0005515	protein binding	GFI1	IPI	UniProtKB:Q13111	Human	PMID:21570500
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	UniProtKB:Q8BGJ9	Mouse	MGI:MGI:3662966|PMID:16819553
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	UniProtKB:P14921	Mouse	MGI:MGI:5319612|PMID:17213822
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	UniProtKB:Q9QWF0	Mouse	MGI:MGI:5142153|PMID:21570500
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	UniProtKB:P17433	Mouse	MGI:MGI:5284783|PMID:17197705
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	UniProtKB:O54714	Mouse	MGI:MGI:5142384|PMID:11060035
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	UniProtKB:Q8CFE3	Mouse	MGI:MGI:5284774|PMID:17707228
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	PR:Q8CFE3	Mouse	PMID:24843136
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	PR:Q8C796	Mouse	PMID:24843136
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	PR:Q6PGA0	Mouse	PMID:24843136
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	UniProtKB:Q96KQ7	Rat	PMID:16287849|RGD:8554797
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	UniProtKB:Q13105-1	Rat	PMID:19164764|RGD:13432319
Molecular Function	GO:0005515	protein binding	Gfi1	IPI	UniProtKB:Q60821	Rat	PMID:19164764|RGD:13432319
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	GFI1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	GFI1	IDA		Human	PMID:15947108
Cellular Component	GO:0016604	nuclear body	GFI1	IDA		Human	PMID:11060035
Cellular Component	GO:0016363	nuclear matrix	GFI1	IDA		Human	PMID:12874834
Cellular Component	GO:0005634	nucleus	GFI1	IDA		Human	PMID:12874834
Cellular Component	GO:0005634	nucleus	GFI1	IDA		Human	PMID:20547752
Cellular Component	GO:0017053	transcription repressor complex	GFI1	IDA		Human	PMID:12874834
Cellular Component	GO:0017053	transcription repressor complex	GFI1	IDA		Human	PMID:19506020
Biological Process	GO:0045165	cell fate commitment	Gfi1	IMP	MGI:MGI:2449921	Mouse	PMID:16230531
Biological Process	GO:0001708	cell fate specification	Gfi1	IMP	MGI:MGI:2449921	Mouse	PMID:16230531
Biological Process	GO:0071222	cellular response to lipopolysaccharide	GFI1	IEP		Human	PMID:20547752
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Gfi1	IEP		Mouse	MGI:MGI:4819887|PMID:20547752
Biological Process	GO:0030218	erythrocyte differentiation	gfi1aa	IMP	ZFIN:ZDB-MRPHLNO-090106-5	Zfish	PMID:22960038
Biological Process	GO:0035315	hair cell differentiation	gfi1ab	IMP	ZFIN:ZDB-MRPHLNO-210524-1	Zfish	PMID:32814237
Biological Process	GO:0035315	hair cell differentiation	gfi1ab	IMP	ZFIN:ZDB-MRPHLNO-210524-2	Zfish	PMID:32814237
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Gfi1	IMP	MGI:MGI:2449921	Mouse	PMID:12441305
Biological Process	GO:0042472	inner ear morphogenesis	Gfi1	IMP	MGI:MGI:2449921	Mouse	PMID:12441305
Biological Process	GO:0007638	mechanosensory behavior	Gfi1	IMP	MGI:MGI:2449921	Mouse	PMID:12441305
Biological Process	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	GFI1	IDA		Human	PMID:15947108
Biological Process	GO:0009996	negative regulation of cell fate specification	Gfi1	IMP	MGI:MGI:2449921	Mouse	PMID:16230531
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	GFI1	IDA		Human	PMID:12874834
Biological Process	GO:0010977	negative regulation of neuron projection development	GFI1	IDA		Human	PMID:19026687
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Gfi1	IMP		Mouse	MGI:MGI:4819887|PMID:20547752
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	GFI1	IDA		Human	PMID:15947108
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	GFI1	IDA		Human	PMID:19506020
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Gfi1	IMP		Mouse	MGI:MGI:4819887|PMID:20547752
Biological Process	GO:0007422	peripheral nervous system development	gfi1ab	IEP		Zfish	PMID:14678828
Biological Process	GO:0042660	positive regulation of cell fate specification	Gfi1	IMP	MGI:MGI:2449921	Mouse	PMID:16230531
Biological Process	GO:0070105	positive regulation of interleukin-6-mediated signaling pathway	GFI1	IDA		Human	PMID:11060035
Biological Process	GO:0060319	primitive erythrocyte differentiation	gfi1aa	IGI	ZFIN:ZDB-GENE-091118-129	Zfish	PMID:30309860
Biological Process	GO:0060319	primitive erythrocyte differentiation	gfi1aa	IMP	ZFIN:ZDB-GENO-190711-13	Zfish	PMID:30309860
Biological Process	GO:0060319	primitive erythrocyte differentiation	gfi1aa	IMP	ZFIN:ZDB-GENO-161215-9	Zfish	PMID:30309860
Biological Process	GO:0060215	primitive hemopoiesis	gfi1aa	IMP	ZFIN:ZDB-MRPHLNO-130304-1	Zfish	PMID:26951200
Biological Process	GO:0060215	primitive hemopoiesis	gfi1aa	IMP	ZFIN:ZDB-MRPHLNO-130304-1	Zfish	PMID:22960038
Biological Process	GO:0060215	primitive hemopoiesis	gfi1aa	IMP	ZFIN:ZDB-MRPHLNO-090106-5	Zfish	PMID:22960038
Biological Process	GO:0034121	regulation of toll-like receptor signaling pathway	GFI1	IDA		Human	PMID:20547752

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern