Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GFRA1
  • Mouse genes Gfra1
  • Rat genes Gfra1
  • Zfish genes gfra1a,gfra1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gfra1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	Gfra1	IPI	RGD:2927	Rat	PMID:18465789|RGD:2325691
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	gfra1a	IDA		Zfish	PMID:28467503
Molecular Function	GO:0005030	neurotrophin receptor activity	Gfra1	IDA		Rat	PMID:8674117|RGD:728874
Molecular Function	GO:0005515	protein binding	Gfra1	IPI	UniProtKB:Q07731	Rat	PMID:10545102|RGD:12793041
Molecular Function	GO:0005515	protein binding	Gfra1	IPI	RGD:2677	Rat	PMID:15709767|RGD:6480096
Molecular Function	GO:0005515	protein binding	Gfra1	IPI	UniProtKB:Q92673	Rat	PMID:23333276|RGD:25671405
Molecular Function	GO:0005515	protein binding	gfra1a	IPI	ZFIN:ZDB-GENE-010226-1	Zfish	PMID:28467503
Cellular Component	GO:0030424	axon	Gfra1	IDA		Rat	PMID:16841166|RGD:1600274
Cellular Component	GO:0009897	external side of plasma membrane	Gfra1	IDA		Rat	PMID:16086681|RGD:6480092
Cellular Component	GO:0070062	extracellular exosome	GFRA1	HDA		Human	PMID:19056867
Cellular Component	GO:0005615	extracellular space	Gfra1	IDA		Rat	PMID:16086681|RGD:6480092
Cellular Component	GO:0043025	neuronal cell body	Gfra1	IDA		Rat	PMID:16841166|RGD:1600274
Cellular Component	GO:0098797	plasma membrane protein complex	Gfra1	IDA		Rat	PMID:10545102|RGD:12793041
Cellular Component	GO:0043235	receptor complex	Gfra1	IDA		Rat	PMID:15709767|RGD:6480096
Biological Process	GO:0007568	aging	Gfra1	IEP		Rat	PMID:20731758|RGD:8693679
Biological Process	GO:0016477	cell migration	Gfra1	IMP		Rat	PMID:16906542|RGD:6480090
Biological Process	GO:0048484	enteric nervous system development	gfra1a	IMP	ZFIN:ZDB-MRPHLNO-060810-2	Zfish	PMID:14660438
Biological Process	GO:0048484	enteric nervous system development	gfra1a	IGI	ZFIN:ZDB-MRPHLNO-060810-2,ZFIN:ZDB-MRPHLNO-060810-3	Zfish	PMID:14660438
Biological Process	GO:0048484	enteric nervous system development	gfra1b	IGI	ZFIN:ZDB-MRPHLNO-060810-2,ZFIN:ZDB-MRPHLNO-060810-3	Zfish	PMID:14660438
Biological Process	GO:0048484	enteric nervous system development	gfra1b	IGI	ZFIN:ZDB-MRPHLNO-060810-2	Zfish	PMID:14660438
Biological Process	GO:0001822	kidney development	Gfra1	IEP		Rat	PMID:15381258|RGD:6480097
Biological Process	GO:0008584	male gonad development	Gfra1	IEP		Rat	PMID:22111653|RGD:6478715
Biological Process	GO:0007399	nervous system development	Gfra1	IMP	MGI:MGI:3045109	Mouse	PMID:11069590
Biological Process	GO:0030182	neuron differentiation	Gfra1	IMP		Rat	PMID:21865882|RGD:6218962
Biological Process	GO:0031175	neuron projection development	Gfra1	IDA		Rat	PMID:15381258|RGD:6480097
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Gfra1	IDA		Rat	PMID:10545102|RGD:12793041
Biological Process	GO:0065003	protein-containing complex assembly	gfra1a	IPI	ZFIN:ZDB-GENE-010226-1,ZFIN:ZDB-GENE-010226-2	Zfish	PMID:29889908
Biological Process	GO:0065003	protein-containing complex assembly	gfra1a	IPI	ZFIN:ZDB-GENE-010226-1,ZFIN:ZDB-GENE-010226-2,ZFIN:ZDB-GENE-980526-307	Zfish	PMID:29889908

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern