Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GGT1,GGT2P,GGT3P,GGTLC1,GGTLC2,GGTLC3
  • Mouse genes Ggt1
  • Rat genes Ggt1
  • Zfish genes ggt1a,ggt1b,ggt1l2.1,ggt1l2.2,si:ch73-236c18.3,si:ch73-59p9.2,si:dkey-222h21.12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ggt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016755	aminoacyltransferase activity	Ggt1	IDA		Rat	PMID:2567161|RGD:12436728
Molecular Function	GO:0036374	glutathione hydrolase activity	GGT1	IDA		Human	PMID:20622017
Molecular Function	GO:0036374	glutathione hydrolase activity	GGT1	IDA		Human	PMID:21447318
Molecular Function	GO:0036374	glutathione hydrolase activity	GGT1	IDA		Human	PMID:23682772
Molecular Function	GO:0036374	glutathione hydrolase activity	GGT1	IDA		Human	PMID:24047895
Molecular Function	GO:0002951	leukotriene-C(4) hydrolase	GGT1	IMP		Human	PMID:14754911
Molecular Function	GO:0002951	leukotriene-C(4) hydrolase	GGT1	IDA		Human	PMID:21447318
Molecular Function	GO:0000048	peptidyltransferase activity	GGT1	IDA		Human	PMID:21447318
Molecular Function	GO:0005515	protein binding	GGT1	IPI	UniProtKB:Q12791	Human	PMID:15528406
Molecular Function	GO:0005515	protein binding	GGTLC2	IPI	UniProtKB:O43711	Human	PMID:32296183
Cellular Component	GO:0005783	endoplasmic reticulum	GGT2P	IDA		Human	PMID:23682772
Cellular Component	GO:0070062	extracellular exosome	GGT3P	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	GGTLC3	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	GGT1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	GGT1	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	GGT2P	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	GGTLC2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	GGT1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	Ggt1	IDA		Rat	PMID:18291430|RGD:2315577
Cellular Component	GO:0048471	perinuclear region of cytoplasm	GGT2P	IDA		Human	PMID:23682772
Cellular Component	GO:0005886	plasma membrane	GGT1	IDA		Human	PMID:23682772
Cellular Component	GO:0031982	vesicle	Ggt1	IDA		Mouse	PMID:23863468
Biological Process	GO:0007568	aging	Ggt1	IEP		Rat	PMID:18309775|RGD:2315578
Biological Process	GO:0006520	amino acid metabolic process	GGT1	IDA		Human	PMID:14754911
Biological Process	GO:0034599	cellular response to oxidative stress	Ggt1	IEP		Rat	PMID:18075840|RGD:2315583
Biological Process	GO:0019344	cysteine biosynthetic process	Ggt1	IMP		Mouse	MGI:MGI:5294309|PMID:12468440
Biological Process	GO:0006631	fatty acid metabolic process	GGT1	IDA		Human	PMID:21447318
Biological Process	GO:0006536	glutamate metabolic process	GGT1	IDA		Human	PMID:21447318
Biological Process	GO:0006536	glutamate metabolic process	GGT1	IDA		Human	PMID:24047895
Biological Process	GO:0006750	glutathione biosynthetic process	Ggt1	IMP		Mouse	MGI:MGI:5294309|PMID:12468440
Biological Process	GO:0006751	glutathione catabolic process	GGT1	IDA		Human	PMID:17924658
Biological Process	GO:0006751	glutathione catabolic process	GGT1	IDA		Human	PMID:21447318
Biological Process	GO:0061017	hepatoblast differentiation	Ggt1	IEP		Rat	PMID:10934156|RGD:14701049
Biological Process	GO:0070365	hepatocyte differentiation	Ggt1	IEP		Rat	PMID:10934156|RGD:14701049
Biological Process	GO:1901750	leukotriene D4 biosynthetic process	GGT1	IMP		Human	PMID:14754911
Biological Process	GO:1901750	leukotriene D4 biosynthetic process	GGT1	IDA		Human	PMID:21447318
Biological Process	GO:0006691	leukotriene metabolic process	GGT1	IDA		Human	PMID:21447318
Biological Process	GO:0097421	liver regeneration	Ggt1	IEP		Rat	PMID:10934156|RGD:14701049
Biological Process	GO:0031179	peptide modification	Ggt1	IDA		Rat	PMID:11601992|RGD:632764
Biological Process	GO:0006508	proteolysis	GGT1	IMP		Human	PMID:14754911
Biological Process	GO:0002682	regulation of immune system process	Ggt1	IMP		Mouse	MGI:MGI:5294309|PMID:12468440
Biological Process	GO:0050727	regulation of inflammatory response	Ggt1	IMP		Mouse	MGI:MGI:5294309|PMID:12468440
Biological Process	GO:0097305	response to alcohol	Ggt1	IEP		Rat	PMID:6113606|RGD:14701046
Biological Process	GO:0032355	response to estradiol	Ggt1	IEP		Rat	PMID:18291430|RGD:2315577
Biological Process	GO:0032496	response to lipopolysaccharide	Ggt1	IEP		Rat	PMID:19699728|RGD:2315572
Biological Process	GO:0034612	response to tumor necrosis factor	Ggt1	IEP		Rat	PMID:16973162|RGD:1601301
Biological Process	GO:0007283	spermatogenesis	Ggt1	IMP	MGI:MGI:1857767	Mouse	PMID:9139708
Biological Process	GO:0031638	zymogen activation	GGT1	IDA		Human	PMID:23682772

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern