Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gh

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CSH1,CSH2,CSHL1,GH1,GH2
- Mouse genes Gh
- Rat genes Gh1
- Zfish genes gh1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008083	growth factor activity	GH1	IPI	UniProtKB:P10912-1	Human	PMID:9360546
Molecular Function	GO:0008083	growth factor activity	GH1	IPI	UniProtKB:P10912-2	Human	PMID:9360546
Molecular Function	GO:0070186	growth hormone activity	gh1	IDA		Zfish	PMID:25333966
Molecular Function	GO:0005131	growth hormone receptor binding	GH1	IPI	UniProtKB:P10912	Human	PMID:1549776
Molecular Function	GO:0005131	growth hormone receptor binding	GH1	IPI	UniProtKB:P10912	Human	PMID:2825030
Molecular Function	GO:0005131	growth hormone receptor binding	GH1	IPI	UniProtKB:P19941	Human	PMID:2825030
Molecular Function	GO:0005131	growth hormone receptor binding	GH1	IDA		Human	PMID:6303755
Molecular Function	GO:0005131	growth hormone receptor binding	GH1	IPI	UniProtKB:P10912	Human	PMID:8943276
Molecular Function	GO:0005131	growth hormone receptor binding	GH1	IPI	UniProtKB:P10912	Human	PMID:9571026
Molecular Function	GO:0005131	growth hormone receptor binding	Gh	IPI	PR:P16882	Mouse	PMID:10556780
Molecular Function	GO:0005131	growth hormone receptor binding	gh1	IMP		Zfish	PMID:25333966
Molecular Function	GO:0005179	hormone activity	Gh1	IDA		Rat	PMID:17258692\|RGD:1624960
Molecular Function	GO:0005148	prolactin receptor binding	GH1	IDA		Human	PMID:10890569
Molecular Function	GO:0005148	prolactin receptor binding	GH1	IPI	UniProtKB:P16471	Human	PMID:7984244
Molecular Function	GO:0005515	protein binding	GH1	IPI	UniProtKB:P10912	Human	PMID:31279174
Molecular Function	GO:0005515	protein binding	GH1	IPI	UniProtKB:P10912	Human	PMID:8943276
Molecular Function	GO:0005515	protein binding	GH1	IPI	UniProtKB:P10912	Human	PMID:9353194
Molecular Function	GO:0005515	protein binding	CSH1	IPI	UniProtKB:O00233	Human	PMID:25009770
Molecular Function	GO:0005515	protein binding	CSH1	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CSH2	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CSH2	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Cellular Component	GO:0062023	collagen-containing extracellular matrix	GH1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Gh1	IDA		Rat	PMID:9255605\|RGD:12904880
Cellular Component	GO:0005829	cytosol	Gh1	IDA		Rat	PMID:16352305\|RGD:1624961
Cellular Component	GO:0005783	endoplasmic reticulum	CSH1	IDA		Human	PMID:6930851
Cellular Component	GO:0005783	endoplasmic reticulum	CSH2	IDA		Human	PMID:6930851
Cellular Component	GO:0005615	extracellular space	GH1	IDA		Human	PMID:11549663
Cellular Component	GO:0005615	extracellular space	Gh	IDA		Mouse	PMID:15985453
Cellular Component	GO:0005615	extracellular space	Gh	IDA		Mouse	PMID:7664670
Cellular Component	GO:0005615	extracellular space	Gh1	IDA		Rat	PMID:19382144\|RGD:2306671
Cellular Component	GO:0070195	growth hormone receptor complex	GH1	IDA		Human	PMID:1549776
Cellular Component	GO:0070195	growth hormone receptor complex	GH1	IDA		Human	PMID:8943276
Cellular Component	GO:0070195	growth hormone receptor complex	GH1	IDA		Human	PMID:9571026
Cellular Component	GO:0005739	mitochondrion	Gh1	IDA		Rat	PMID:16352305\|RGD:1624961
Cellular Component	GO:0005634	nucleus	Gh	IDA		Mouse	PMID:9144201
Cellular Component	GO:0005634	nucleus	Gh1	IDA		Rat	PMID:19370506\|RGD:2315624
Cellular Component	GO:0005886	plasma membrane	Gh	IDA		Mouse	PMID:9144201
Cellular Component	GO:0030141	secretory granule	Gh	IDA		Mouse	PMID:1329576
Cellular Component	GO:0030141	secretory granule	Gh1	IDA		Rat	PMID:2980232\|RGD:2315687
Cellular Component	GO:0005802	trans-Golgi network	Gh	IDA		Mouse	PMID:9144201
Cellular Component	GO:0031982	vesicle	CSH1	IDA		Human	PMID:6930851
Cellular Component	GO:0031982	vesicle	CSH2	IDA		Human	PMID:6930851
Biological Process	GO:0060612	adipose tissue development	gh1	IMP	ZFIN:ZDB-GENO-130701-1	Zfish	PMID:23456361
Biological Process	GO:0048513	animal organ development	Gh1	IEP		Rat	PMID:2722883\|RGD:728551
Biological Process	GO:0070977	bone maturation	GH1	IDA		Human	PMID:20110402
Biological Process	GO:0071469	cellular response to alkaline pH	Gh1	IEP		Rat	PMID:23639351\|RGD:10003149
Biological Process	GO:0032869	cellular response to insulin stimulus	Gh	IDA		Mouse	PMID:16513828
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	Gh1	IEP		Rat	PMID:1730572\|RGD:12904879
Biological Process	GO:0007565	female pregnancy	Gh1	IEP		Rat	PMID:18208550\|RGD:2315640
Biological Process	GO:0060396	growth hormone receptor signaling pathway	GH1	IDA		Human	PMID:8063815
Biological Process	GO:0048286	lung alveolus development	Gh1	IMP		Rat	PMID:18985281\|RGD:2315627
Biological Process	GO:0010259	multicellular organism aging	Gh1	IEP		Rat	PMID:9492067\|RGD:152176652
Biological Process	GO:1901215	negative regulation of neuron death	Gh1	IDA		Rat	PMID:17258692\|RGD:1624960
Biological Process	GO:0007405	neuroblast proliferation	Gh1	IDA		Rat	PMID:19524466\|RGD:2315620
Biological Process	GO:0010536	positive regulation of activation of Janus kinase activity	GH1	IDA		Human	PMID:12552091
Biological Process	GO:0010828	positive regulation of glucose transmembrane transport	GH1	IDA		Human	PMID:9144201
Biological Process	GO:0045927	positive regulation of growth	Gh1	IMP		Rat	PMID:8398130\|RGD:2315643
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	GH1	IDA		Human	PMID:7565946
Biological Process	GO:0050996	positive regulation of lipid catabolic process	gh1	IMP	ZFIN:ZDB-GENO-130701-1	Zfish	PMID:23456361
Biological Process	GO:0040018	positive regulation of multicellular organism growth	GH1	IDA		Human	PMID:20110402
Biological Process	GO:0040018	positive regulation of multicellular organism growth	GH1	IDA		Human	PMID:7565946
Biological Process	GO:0040018	positive regulation of multicellular organism growth	GH1	IMP		Human	PMID:8496314
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Gh	IGI	MGI:MGI:1342540	Mouse	PMID:16467156
Biological Process	GO:0050769	positive regulation of neurogenesis	Gh1	IDA		Rat	PMID:19524466\|RGD:2315620
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GH1	IDA		Human	PMID:7782332
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GH1	IDA		Human	PMID:7782332
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GH1	IDA		Human	PMID:8923468
Biological Process	GO:0090031	positive regulation of steroid hormone biosynthetic process	Gh1	IDA		Rat	PMID:17023532\|RGD:1600072
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GH1	IDA		Human	PMID:12552091
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GH1	IDA		Human	PMID:8923468
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	GH1	IDA		Human	PMID:8063815
Biological Process	GO:0034097	response to cytokine	Gh1	IEP		Rat	PMID:18753332\|RGD:2315636
Biological Process	GO:0032355	response to estradiol	GH1	IDA		Human	PMID:12552091
Biological Process	GO:0032355	response to estradiol	Gh1	IEP		Rat	PMID:9681512\|RGD:12905044
Biological Process	GO:0032094	response to food	Gh	IDA		Mouse	PMID:16513828
Biological Process	GO:0009416	response to light stimulus	Gh1	IDA		Rat	PMID:19091612\|RGD:2315626
Biological Process	GO:0043434	response to peptide hormone	Gh1	IEP		Rat	PMID:19439817\|RGD:2315623

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.