Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ghr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GHR
- Mouse genes Ghr
- Rat genes Ghr
- Zfish genes ghra,ghrb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ghr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004903	growth hormone receptor activity	Ghr	IDA		Mouse	PMID:6303755
Molecular Function	GO:0004903	growth hormone receptor activity	Ghr	IDA		Rat	PMID:11244571\|RGD:1624962
Molecular Function	GO:0004903	growth hormone receptor activity	Ghr	IDA		Rat	PMID:17258692\|RGD:1624960
Molecular Function	GO:0042802	identical protein binding	GHR	IPI	UniProtKB:P10912	Human	PMID:16116438
Molecular Function	GO:0008289	lipid binding	GHR	EXP		Human	PMID:25846210
Molecular Function	GO:0017046	peptide hormone binding	GHR	IPI	UniProtKB:P01241	Human	PMID:1549776
Molecular Function	GO:0017046	peptide hormone binding	GHR	IPI	UniProtKB:P01241	Human	PMID:2825030
Molecular Function	GO:0017046	peptide hormone binding	GHR	IPI	UniProtKB:P01241	Human	PMID:8943276
Molecular Function	GO:0017046	peptide hormone binding	GHR	IPI	UniProtKB:P01241	Human	PMID:9571026
Molecular Function	GO:0017046	peptide hormone binding	Ghr	IPI	PR:P06880	Mouse	PMID:10556780
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P29597	Human	PMID:10502458
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P52332	Human	PMID:10502458
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:Q62689	Human	PMID:10502458
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:Q9JLI4	Human	PMID:10866662
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P17706	Human	PMID:12907755
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P18031	Human	PMID:12907755
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P23467	Human	PMID:12907755
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P26045	Human	PMID:12907755
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P43378	Human	PMID:12907755
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:Q16829	Human	PMID:12907755
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:Q9HD43	Human	PMID:12907755
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P23467	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:Q12913	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P16333	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P01241	Human	PMID:31279174
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P01241	Human	PMID:8943276
Molecular Function	GO:0005515	protein binding	GHR	IPI	UniProtKB:P01241	Human	PMID:9353194
Molecular Function	GO:0005515	protein binding	Ghr	IPI	UniProtKB:P42230	Mouse	MGI:MGI:82362\|PMID:8702683
Molecular Function	GO:0042803	protein homodimerization activity	GHR	IDA		Human	PMID:1549776
Molecular Function	GO:0042803	protein homodimerization activity	GHR	IDA		Human	PMID:8137822
Molecular Function	GO:0042803	protein homodimerization activity	GHR	IDA		Human	PMID:8943276
Molecular Function	GO:0019901	protein kinase binding	Ghr	IPI	RGD:2939	Rat	PMID:11244571\|RGD:1624962
Molecular Function	GO:0019901	protein kinase binding	Ghr	IPI	RGD:69056	Rat	PMID:11244571\|RGD:1624962
Molecular Function	GO:0019901	protein kinase binding	Ghr	IDA		Rat	PMID:8063815\|RGD:8553732
Molecular Function	GO:0019903	protein phosphatase binding	Ghr	IMP		Rat	PMID:10976913\|RGD:1624964
Molecular Function	GO:0019903	protein phosphatase binding	Ghr	IPI	RGD:731746	Rat	PMID:10976913\|RGD:1624964
Molecular Function	GO:0042169	SH2 domain binding	Ghr	IMP		Rat	PMID:10976913\|RGD:1624964
Molecular Function	GO:0042169	SH2 domain binding	Ghr	IPI	RGD:731746	Rat	PMID:10976913\|RGD:1624964
Molecular Function	GO:0042169	SH2 domain binding	Ghr	IDA		Rat	PMID:12586763\|RGD:728498
Cellular Component	GO:0009986	cell surface	GHR	IDA		Human	PMID:8137822
Cellular Component	GO:0005737	cytoplasm	Ghr	IDA		Rat	PMID:12162495\|RGD:728761
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	GHR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	GHR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	GHR	IMP		Human	PMID:2825030
Cellular Component	GO:0005615	extracellular space	GHR	IDA		Human	PMID:8137822
Cellular Component	GO:0005615	extracellular space	Ghr	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Ghr	IDA		Rat	PMID:11126270\|RGD:2307382
Cellular Component	GO:0070195	growth hormone receptor complex	GHR	IDA		Human	PMID:1549776
Cellular Component	GO:0070195	growth hormone receptor complex	GHR	IDA		Human	PMID:8137822
Cellular Component	GO:0070195	growth hormone receptor complex	GHR	IDA		Human	PMID:8943276
Cellular Component	GO:0070195	growth hormone receptor complex	GHR	IDA		Human	PMID:9571026
Cellular Component	GO:0016020	membrane	GHR	IDA		Human	PMID:1549776
Cellular Component	GO:0016020	membrane	Ghr	IDA		Mouse	PMID:11834450
Cellular Component	GO:0005739	mitochondrion	Ghr	IDA		Rat	PMID:16352305\|RGD:1624961
Cellular Component	GO:0043025	neuronal cell body	Ghr	IDA		Rat	PMID:17258692\|RGD:1624960
Cellular Component	GO:0005634	nucleus	Ghr	IDA		Mouse	PMID:9144201
Cellular Component	GO:0005634	nucleus	Ghr	IDA		Rat	PMID:12162495\|RGD:728761
Cellular Component	GO:0005886	plasma membrane	GHR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	GHR	IDA		Human	PMID:8137822
Cellular Component	GO:0005886	plasma membrane	Ghr	IDA		Mouse	PMID:9144201
Cellular Component	GO:0005886	plasma membrane	Ghr	IDA		Rat	PMID:17258692\|RGD:1624960
Cellular Component	GO:0043235	receptor complex	GHR	IDA		Human	PMID:8137822
Biological Process	GO:0042976	activation of Janus kinase activity	Ghr	IDA		Rat	PMID:11244571\|RGD:1624962
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Ghr	IEP		Rat	PMID:15749813\|RGD:2307373
Biological Process	GO:0032870	cellular response to hormone stimulus	GHR	IMP		Human	PMID:7565946
Biological Process	GO:0032869	cellular response to insulin stimulus	Ghr	IEP		Rat	PMID:18040895\|RGD:2307371
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Ghr	IDA		Mouse	MGI:MGI:55531\|PMID:6303755
Biological Process	GO:0060396	growth hormone receptor signaling pathway	GHR	IMP		Human	PMID:7565946
Biological Process	GO:0060396	growth hormone receptor signaling pathway	Ghr	IDA		Mouse	MGI:MGI:82362\|PMID:8702683
Biological Process	GO:0060396	growth hormone receptor signaling pathway	Ghr	IDA		Rat	PMID:8063815\|RGD:8553732
Biological Process	GO:0042445	hormone metabolic process	GHR	IMP		Human	PMID:8137822
Biological Process	GO:0009755	hormone-mediated signaling pathway	Ghr	IDA		Rat	PMID:11064147\|RGD:1624963
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	GHR	IMP		Human	PMID:7565946
Biological Process	GO:0051179	localization	GHR	EXP		Human	PMID:25846210
Biological Process	GO:1901215	negative regulation of neuron death	Ghr	IMP		Rat	PMID:17258692\|RGD:1624960
Biological Process	GO:0045597	positive regulation of cell differentiation	Ghr	IEP		Rat	PMID:12162495\|RGD:728761
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Ghr	IDA		Rat	PMID:8063815\|RGD:8553732
Biological Process	GO:0040018	positive regulation of multicellular organism growth	GHR	IMP		Human	PMID:2813379
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Ghr	IDA		Mouse	MGI:MGI:82362\|PMID:8702683
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Ghr	IMP		Rat	PMID:10976913\|RGD:1624964
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Ghr	IDA		Rat	PMID:11064147\|RGD:1624963
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Ghr	IDA		Rat	PMID:8063815\|RGD:8553732
Biological Process	GO:0040014	regulation of multicellular organism growth	Ghr	IMP		Mouse	MGI:MGI:3804595\|PMID:18648510
Biological Process	GO:0034097	response to cytokine	Ghr	IEP		Rat	PMID:12654216\|RGD:2307380
Biological Process	GO:0032094	response to food	Ghr	IEP		Rat	PMID:17634149\|RGD:2307372
Biological Process	GO:0051384	response to glucocorticoid	Ghr	IEP		Rat	PMID:12162495\|RGD:728761
Biological Process	GO:0009629	response to gravity	Ghr	IEP		Rat	PMID:14638460\|RGD:151361116
Biological Process	GO:0060416	response to growth hormone	Ghr	IEP		Rat	PMID:10987684\|RGD:11567220
Biological Process	GO:0009725	response to hormone	Ghr	IEP		Rat	PMID:12162495\|RGD:728761
Biological Process	GO:0070555	response to interleukin-1	Ghr	IEP		Rat	PMID:14518239\|RGD:2307375
Biological Process	GO:0043278	response to morphine	Ghr	IEP		Rat	PMID:11335057\|RGD:2307381
Biological Process	GO:0043434	response to peptide hormone	Ghr	IEP		Rat	PMID:15334695\|RGD:2307377
Biological Process	GO:0019530	taurine metabolic process	Ghr	IMP		Mouse	MGI:MGI:3804595\|PMID:18648510

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.